Short Protecting Group-free Syntheses of CDE Synthon of Racemic Camptothecin

Author(s): Pingxuan Shao, Wei Lu, Lei Wang*

Journal Name: Current Organic Synthesis

Volume 17 , Issue 7 , 2020


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Graphical Abstract:


Abstract:

A practical and concise total synthesis of tricyclic ketone 7 (CDE ring), a valuable intermediate for the synthesis of racemic camptothecin and analogs, was described (8 chemical steps and 29% overall yield). The synthesis starts with two inexpensive, readily available materials and is operationally simple to perform. It is worth mentioning that the reported protecting group-free synthesis, with advantages of a short route, would be helpful for the future development of industry-scale syntheses of camptothecin-family alkaloids.

Keywords: Natural product, alkaloid, camptothecin, CDE ring, total syntheses, protecting group-free.

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Article Details

VOLUME: 17
ISSUE: 7
Year: 2020
Published on: 11 June, 2020
Page: [588 - 591]
Pages: 4
DOI: 10.2174/1570179417666200611125740
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