Short Protecting Group-free Syntheses of CDE Synthon of Racemic Camptothecin

(E-pub Ahead of Print)

Author(s): Pingxuan Shao, Wei Lu, Lei Wang*

Journal Name: Current Organic Synthesis

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A practical and concise total synthesis of tricyclic ketone 7 (CDE ring), a valuable intermediate for the synthesis of racemic camptothecin and analogs, was described (8 chemical steps and 29% overall yield). The synthesis starts with two inexpensive, readily available materials and is operationally simple to perform. It is worth mentioning that the reported protecting group-free synthesis, with advantages of a short route, would be helpful for the future development of industry scale syntheses of camptothecin-family alkaloids.

Keywords: Natural product, Alkaloid, Camptothecin, CDE ring, Total syntheses, Protecting group-free.

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(E-pub Ahead of Print)
DOI: 10.2174/1570179417666200611125740
Price: $95

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