Background: Benzimidazole derivatives are an important class of heterocyclic compounds in organic
chemistry since are related to a wide range of biological properties including antimicrobial activity.
Methods: A series of 1-naphthoyl and benzoyl benzimidazole derivatives were synthesised, identified and screened
for their antimicrobial activities against a number of different test organisms such as Escherichia coli, Pseudomonas
aureginosa, Klebsiella pneumoniae, Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Salmonella
typhimurium, Candida albicans (yeast).
Results: Benzimidazole derivatives (3a-d) were synthesised by using 4 different aminoacids. L-methionine, Lisoleucine, D-Phenylysine and L-Phenylamine as starting materials in the study. Experimental studies involve the use
of benzimidazole derivatives (3a-d) of the selected amino acids to synthesize the benzoyl and naphthoyl derivatives of
benzimidazole (4a-d, 5a-c). The structures of the synthesized compounds were confirmed by spectroscopic analyses
(FTIR, 1H-NMR, 13C-NMR) and elemental analysis.
Conclusion: In this study, only one compound (5a) showed a low MIC value against the eukaryotic microorganism C.
albicans. The other six compounds showed higher antimicrobial activities against the prokaryotes C. albicans which is
a normal flora in the mouth but is one of the organisms that cause infections leading to the weakening of the human
immune system. Compound 5a is a candidate for future alternative antimicrobial drugs against C. albicans infections.
In addition, compound 5a has potentials to be used as an inhibitor against P. aureginosa for the treatment of cystic