Comprehensive Analysis Reveals GPRIN1 is a Potential Biomarker for non-small Cell Lung Cancer

(E-pub Ahead of Print)

Author(s): Jian Li*, Zheng Gong, Haicheng Jiang, Jie Gao, Jianwei Liang, Peng Chang, Yulong Hou

Journal Name: Current Bioinformatics

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Abstract:

Non-small cell lung cancer (NSCLC) is one of the most leading cause of tumor related mortality worldwide. However, the prognosis of NSCLC remained to be poor and the mechanisms remained to be further investigated. This study showed GPRIN1 was overexpressed and correlated to shorter OS time in human cancers. In NSCLC, we found that GPRIN1 was up-regulated in NSCLC samples compared to normal lung tissues by analyzing TCGA and GEO datasets. Bioinformatics analysis indicated that this gene was involved in regulating cancer proliferation and metabolism. Finally, we identiifed key targets of GPRIN1 in NSCLC by constructing PPl networks, including MCM3, KIF20A, UHRF1, BRCA1, KIF4A, HMMR, KIF18B, KIFC1, ASPM, and NCAPG2. These analyses showed GPRIN1 could act as a prognosis biomarker in patients with NSCLC.

Keywords: Non-small cell lung cancer, GPRIN1, prognosis, biomarker

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1574893615999200530201333
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