Introduction: Quinoxalines show diversified applications in the field of medicinal chemistry.
Materials and Methods: Therefore, we have designed highly efficient, environmentally benign and one-pot
protocol for the synthesis of 2-phenylquinoxaline from the reaction of Acetophenone, N-bromosuccinimide and
1,2-phenylenediamine under ultrasound irradiation in glycerol-water.
Results and Discussion: We observed that, although the reaction efficiently completed in all of these solvents,
the use of glycerol-water with different ratio give consistently higher yields (89–94%) and decrease reaction times.
Conclusion: The main advantages of this protocol are green method; avoid use of toxic catalyst and volatile
organic medium and product obtained with excellent yield.