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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Antithrombotic Therapy in Carotid Artery Disease

Author(s): Paraskevi Papanikolaou, Alexios S. Antonopoulos, Irene Mastorakou, Andreas Angelopoulos, Efthalia Kostoula, Xara-Vasiliki Mystakidi, Spyros Simantiris, Nikolaos Galiatsatos, Evangelos Oikonomou and Dimitris Tousoulis*

Volume 26, Issue 23, 2020

Page: [2725 - 2734] Pages: 10

DOI: 10.2174/1381612826666200518111359

Price: $65

Abstract

The management of asymptomatic atherosclerotic carotid artery disease and the role of antithrombotic therapy is of increasing importance for stroke prevention. Non-invasive imaging of carotid plaques can identify high-risk plaque features that are associated with the risk of plaque rupture. Carotid plaque necrosis, hemorrhage, fibrous cap thinning, and the presence of foam cells have all been correlated with the risk of rupture and onset of neurological symptoms in patients with carotid stenosis. Antiplatelets are currently recommended for patients with a history of ischemic stroke and/or significant carotid artery stenosis, with aspirin and clopidogrel being the most widely used and studied agents. The role of dual antiplatelet therapy remains controversial. Moreover, there is scarce evidence on the role of newer anticoagulant agents in stable patients with carotid artery stenosis. In this review article, we discuss the pathophysiology of carotid atherosclerosis, the use of non-invasive imaging for detecting the vulnerable carotid plaque and summarize the existing clinical evidence on the use of antiplatelet and antithrombotic agents in carotid artery disease.

Keywords: Antithrombotic therapy, carotid artery disease, vulnerable carotid plaque, antiplatelet therapy, anticoagulants, peripheral artery disease.

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[1]
Guzik A, Bushnell C. Stroke Epidemiology and Risk Factor Management Continuum (Minneap Minn) 2017; 23(1, Cerebrovascular Disease): 15-39.
[http://dx.doi.org/10.1212/CON.0000000000000416]
[2]
Feigin VL, Mensah GA, Norrving B, Murray CJ, Roth GA, Group GBDSPE. GBD 2013 Stroke Panel Experts Group. Atlas of the Global Burden of Stroke (1990-2013): The GBD 2013 Study. Neuroepidemiology 2015; 45(3): 230-6.
[http://dx.doi.org/10.1159/000441106] [PMID: 26505985]
[3]
Feigin VL, Krishnamurthi RV, Parmar P, et al. GBD 2013 Writing Group; GBD 2013 Stroke Panel Experts Group. Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study. Neuroepidemiology 2015; 45(3): 161-76.
[http://dx.doi.org/10.1159/000441085] [PMID: 26505981]
[4]
Esenwa C, Gutierrez J. Secondary stroke prevention: challenges and solutions. Vasc Health Risk Manag 2015; 11: 437-50.
[http://dx.doi.org/10.2147/VHRM.S63791] [PMID: 26300647]
[5]
Kuo F, Gardener H, Dong C, et al. Traditional cardiovascular risk factors explain the minority of the variability in carotid plaque. Stroke 2012; 43(7): 1755-60.
[http://dx.doi.org/10.1161/STROKEAHA.112.651059] [PMID: 22550054]
[6]
Casadei A, Floreani M, Catalini R, Serra C, Assanti AP, Conci P. Sonographic characteristics of carotid artery plaques: Implications for follow-up planning? J Ultrasound 2012; 15(3): 151-7.
[http://dx.doi.org/10.1016/j.jus.2012.06.002] [PMID: 23458826]
[7]
Redgrave JN, Gallagher P, Lovett JK, Rothwell PM. Critical cap thickness and rupture in symptomatic carotid plaques: the oxford plaque study. Stroke 2008; 39(6): 1722-9.
[http://dx.doi.org/10.1161/STROKEAHA.107.507988] [PMID: 18403733]
[8]
Yang D, Iyer S, Gardener H, et al. Cigarette Smoking and Carotid Plaque Echodensity in the Northern Manhattan Study. Cerebrovasc Dis 2015; 40(3-4): 136-43.
[http://dx.doi.org/10.1159/000434761] [PMID: 26227885]
[9]
Högberg D, Kragsterman B, Björck M, Tjärnström J, Wanhainen A. Carotid artery atherosclerosis among 65-year-old Swedish men - a population-based screening study. Eur J Vasc Endovasc Surg 2014; 48(1): 5-10.
[http://dx.doi.org/10.1016/j.ejvs.2014.02.004] [PMID: 24631197]
[10]
Tattersall MC, Gassett A, Korcarz CE, et al. Predictors of carotid thickness and plaque progression during a decade: the Multi-Ethnic Study of Atherosclerosis. Stroke 2014; 45(11): 3257-62.
[http://dx.doi.org/10.1161/STROKEAHA.114.005669] [PMID: 25213342]
[11]
Prati P, Vanuzzo D, Casaroli M, et al. Prevalence and determinants of carotid atherosclerosis in a general population. Stroke 1992; 23(12): 1705-11.
[http://dx.doi.org/10.1161/01.STR.23.12.1705] [PMID: 1448818]
[12]
Sillesen H, Muntendam P, Adourian A, et al. Carotid plaque burden as a measure of subclinical atherosclerosis: comparison with other tests for subclinical arterial disease in the High Risk Plaque BioImage study. JACC Cardiovasc Imaging 2012; 5(7): 681-9.
[http://dx.doi.org/10.1016/j.jcmg.2012.03.013] [PMID: 22789936]
[13]
Wang W, Wu YF, Zhao D, et al. [Distribution characteristics and risk factors of carotid atherosclerosis in middle-aged and elderly Chinese]. Zhonghua Xin Xue Guan Bing Za Zhi 2010; 38(6): 553-7.
[PMID: 21033140]
[14]
Kwon TG, Kim KW, Park HW, Jeong JH, Kim KY, Bae JH. Prevalence and significance of carotid plaques in patients with coronary atherosclerosis. Korean Circ J 2009; 39(8): 317-21.
[http://dx.doi.org/10.4070/kcj.2009.39.8.317] [PMID: 19949637]
[15]
Mathiesen EB, Joakimsen O, Bønaa KH. Prevalence of and risk factors associated with carotid artery stenosis: the Tromsø Study. Cerebrovasc Dis 2001; 12(1): 44-51.
[http://dx.doi.org/10.1159/000047680] [PMID: 11435679]
[16]
Ota H, Reeves MJ, Zhu DC, et al. Sex differences in patients with asymptomatic carotid atherosclerotic plaque: in vivo 3.0-T magnetic resonance study. Stroke 2010; 41(8): 1630-5.
[http://dx.doi.org/10.1161/STROKEAHA.110.581306] [PMID: 20616325]
[17]
Jacobs AK. Women, ischemic heart disease, revascularization, and the gender gap: what are we missing? J Am Coll Cardiol 2006; 47(3)(Suppl.): S63-5.
[http://dx.doi.org/10.1016/j.jacc.2004.12.085] [PMID: 16458174]
[18]
Bijari PB, Wasserman BA, Steinman DA. Carotid bifurcation geometry is an independent predictor of early wall thickening at the carotid bulb. Stroke 2014; 45(2): 473-8.
[http://dx.doi.org/10.1161/STROKEAHA.113.003454] [PMID: 24357655]
[19]
Schulz UG, Rothwell PM. Sex differences in carotid bifurcation anatomy and the distribution of atherosclerotic plaque. Stroke 2001; 32(7): 1525-31.
[http://dx.doi.org/10.1161/01.STR.32.7.1525] [PMID: 11441196]
[20]
Abiko A, Makita S, Naganuma Y, Nagai M, Nakamura M. Association between metabolic syndrome and carotid atherosclerosis: relevance of combined criteria including the serum adiponectin level for the general population. Intern Med 2011; 50(5): 381-7.
[http://dx.doi.org/10.2169/internalmedicine.50.4476] [PMID: 21372446]
[21]
Ebrahim S, Papacosta O, Whincup P, et al. Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British Regional Heart Study. Stroke 1999; 30(4): 841-50.
[http://dx.doi.org/10.1161/01.STR.30.4.841] [PMID: 10187889]
[22]
Sobieszczyk P, Beckman J. Carotid artery disease. Circulation 2006; 114(7): e244-7.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.105.542860] [PMID: 16908775]
[23]
Tell GS, Polak JF, Ward BJ, Kittner SJ, Savage PJ, Robbins J. The Cardiovascular Health Study (CHS) Collaborative Research Group. Relation of smoking with carotid artery wall thickness and stenosis in older adults. The Cardiovascular Health Study. Circulation 1994; 90(6): 2905-8.
[http://dx.doi.org/10.1161/01.CIR.90.6.2905] [PMID: 7994837]
[24]
Camilo O, Goldstein LB. Non-atherosclerotic vascular disease in the young. J Thromb Thrombolysis 2005; 20(2): 93-103.
[http://dx.doi.org/10.1007/s11239-005-3203-7] [PMID: 16205858]
[25]
Kim ST, Cloft H, Flemming KD, Kallmes DF, Lanzino G, Brinjikji W. Increased Prevalence of Cerebrovascular Disease in Hospitalized Patients with Marfan Syndrome. J Stroke Cerebrovasc Dis 2018; 27(2): 296-300.
[http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.08.036] [PMID: 29030048]
[26]
Plouin PF, Baguet JP, Thony F, et al. ARCADIA Investigators. High Prevalence of Multiple Arterial Bed Lesions in Patients With Fibromuscular Dysplasia: The ARCADIA Registry (Assessment of Renal and Cervical Artery Dysplasia). Hypertension 2017; 70(3): 652-8.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09539] [PMID: 28716989]
[27]
Garg SK, Mohan S, Kumar S. Diagnostic value of 3D contrast-enhanced magnetic resonance angiography in Takayasu’s arteritis-a comparative study with digital subtraction angiography. Eur Radiol 2011; 21(8): 1658-66.
[http://dx.doi.org/10.1007/s00330-011-2090-x] [PMID: 21344303]
[28]
Grant EG, Benson CB, Moneta GL, et al. Carotid artery stenosis: gray-scale and Doppler US diagnosis-Society of Radiologists in Ultrasound Consensus Conference. Radiology 2003; 229(2): 340-6.
[http://dx.doi.org/10.1148/radiol.2292030516] [PMID: 14500855]
[29]
Debrey SM, Yu H, Lynch JK, et al. Diagnostic accuracy of magnetic resonance angiography for internal carotid artery disease: a systematic review and meta-analysis. Stroke 2008; 39(8): 2237-48.
[http://dx.doi.org/10.1161/STROKEAHA.107.509877] [PMID: 18556586]
[30]
Samarzija K, Milosevic P, Jurjevic Z, Erdeljac E. Grading of carotid artery stenosis with computed tomography angiography: whether to use the narrowest diameter or the cross-sectional area. Insights Imaging 2018; 9(4): 527-34.
[http://dx.doi.org/10.1007/s13244-018-0622-5] [PMID: 29799095]
[31]
Hingwala D, Kesavadas C, Sylaja PN, Thomas B, Kapilamoorthy TR. Multimodality imaging of carotid atherosclerotic plaque: Going beyond stenosis. Indian J Radiol Imaging 2013; 23(1): 26-34.
[http://dx.doi.org/10.4103/0971-3026.113616] [PMID: 23986615]
[32]
Nederkoorn PJ, van der Graaf Y, Hunink MG. Duplex ultrasound and magnetic resonance angiography compared with digital subtraction angiography in carotid artery stenosis: a systematic review. Stroke 2003; 34(5): 1324-32.
[http://dx.doi.org/10.1161/01.STR.0000068367.08991.A2] [PMID: 12690221]
[33]
Amato M, Veglia F, de Faire U, et al. IMPROVE study group. Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification. Atherosclerosis 2017; 263: 412-9.
[http://dx.doi.org/10.1016/j.atherosclerosis.2017.05.023] [PMID: 28602434]
[34]
Chambless LE, Folsom AR, Clegg LX, et al. Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol 2000; 151(5): 478-87.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a010233] [PMID: 10707916]
[35]
Kitamura A, Iso H, Imano H, et al. Carotid intima-media thickness and plaque characteristics as a risk factor for stroke in Japanese elderly men. Stroke 2004; 35(12): 2788-94.
[http://dx.doi.org/10.1161/01.STR.0000147723.52033.9e] [PMID: 15528460]
[36]
Rosvall M, Janzon L, Berglund G, Engström G, Hedblad B. Incident coronary events and case fatality in relation to common carotid intima-media thickness. J Intern Med 2005; 257(5): 430-7.
[http://dx.doi.org/10.1111/j.1365-2796.2005.01485.x] [PMID: 15836659]
[37]
Piepoli MF, Hoes AW, Agewall S, et al. ESC Scientific Document Group. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts)Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J 2016; 37(29): 2315-81.
[http://dx.doi.org/10.1093/eurheartj/ehw106] [PMID: 27222591]
[38]
Schaar JA, Muller JE, Falk E, et al. Terminology for high-risk and vulnerable coronary artery plaques. Report of a meeting on the vulnerable plaque, June 17 and 18, 2003, Santorini, Greece. Eur Heart J 2004; 25(12): 1077-82.
[http://dx.doi.org/10.1016/j.ehj.2004.01.002] [PMID: 15191780]
[39]
Libby P. Inflammation in atherosclerosis. Nature 2002; 420(6917): 868-74.
[http://dx.doi.org/10.1038/nature01323] [PMID: 12490960]
[40]
Stary HC. Natural history and histological classification of atherosclerotic lesions: an update. Arterioscler Thromb Vasc Biol 2000; 20(5): 1177-8.
[http://dx.doi.org/10.1161/01.ATV.20.5.1177] [PMID: 10807728]
[41]
Altaf N, Goode SD, Beech A, et al. Plaque hemorrhage is a marker of thromboembolic activity in patients with symptomatic carotid disease. Radiology 2011; 258(2): 538-45.
[http://dx.doi.org/10.1148/radiol.10100198] [PMID: 21163919]
[42]
Kolodgie FD, Gold HK, Burke AP, et al. Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med 2003; 349(24): 2316-25.
[http://dx.doi.org/10.1056/NEJMoa035655] [PMID: 14668457]
[43]
McCarthy MJ, Loftus IM, Thompson MM, et al. Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology. J Vasc Surg 1999; 30(2): 261-8.
[http://dx.doi.org/10.1016/S0741-5214(99)70136-9] [PMID: 10436445]
[44]
Moreno PR, Purushothaman KR, Fuster V, et al. Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability. Circulation 2004; 110(14): 2032-8.
[http://dx.doi.org/10.1161/01.CIR.0000143233.87854.23] [PMID: 15451780]
[45]
Takaya N, Yuan C, Chu B, et al. Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study. Circulation 2005; 111(21): 2768-75.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.104.504167] [PMID: 15911695]
[46]
Kurosaki Y, Yoshida K, Endo H, Chin M, Yamagata S. Association between carotid atherosclerosis plaque with high signal intensity on T1-weighted imaging and subsequent ipsilateral ischemic events. Neurosurgery 2011; 68(1): 62-7.
[http://dx.doi.org/10.1227/NEU.0b013e3181fc60a8] [PMID: 21099723]
[47]
Underhill HR, Yuan C. Carotid MRI: a tool for monitoring individual response to cardiovascular therapy? Expert Rev Cardiovasc Ther 2011; 9(1): 63-80.
[http://dx.doi.org/10.1586/erc.10.172] [PMID: 21166529]
[48]
Sadat U, Weerakkody RA, Bowden DJ, et al. Utility of high resolution MR imaging to assess carotid plaque morphology: a comparison of acute symptomatic, recently symptomatic and asymptomatic patients with carotid artery disease. Atherosclerosis 2009; 207(2): 434-9.
[http://dx.doi.org/10.1016/j.atherosclerosis.2009.05.002] [PMID: 19520370]
[49]
Zhang C, Chaudhary N, Gemmete JJ, et al. Correlation of thrombus formation on 7 T MRI with histology in a rat carotid artery side wall aneurysm model. J Neurointerv Surg 2014; 6(10): 780-4.
[http://dx.doi.org/10.1136/neurintsurg-2013-011032] [PMID: 24335805]
[50]
Sun J, Zhao XQ, Balu N, et al. Carotid Plaque Lipid Content and Fibrous Cap Status Predict Systemic CV Outcomes: The MRI Substudy in AIM-HIGH. JACC Cardiovasc Imaging 2017; 10(3): 241-9.
[http://dx.doi.org/10.1016/j.jcmg.2016.06.017] [PMID: 28279371]
[51]
de Weert TT, Ouhlous M, Meijering E, et al. In vivo characterization and quantification of atherosclerotic carotid plaque components with multidetector computed tomography and histopathological correlation. Arterioscler Thromb Vasc Biol 2006; 26(10): 2366-72.
[http://dx.doi.org/10.1161/01.ATV.0000240518.90124.57] [PMID: 16902158]
[52]
Ajduk M, Pavić L, Bulimbasić S, et al. Multidetector-row computed tomography in evaluation of atherosclerotic carotid plaques complicated with intraplaque hemorrhage. Ann Vasc Surg 2009; 23(2): 186-93.
[http://dx.doi.org/10.1016/j.avsg.2008.05.008] [PMID: 18657388]
[53]
Saba L, Mallarin G. Window settings for the study of calcified carotid plaques with multidetector CT angiography. AJNR Am J Neuroradiol 2009; 30(7): 1445-50.
[http://dx.doi.org/10.3174/ajnr.A1509] [PMID: 19299487]
[54]
Hardie AD, Kramer CM, Raghavan P, Baskurt E, Nandalur KR. The impact of expansive arterial remodeling on clinical presentation in carotid artery disease: a multidetector CT angiography study. AJNR Am J Neuroradiol 2007; 28(6): 1067-70.
[http://dx.doi.org/10.3174/ajnr.A0508] [PMID: 17569959]
[55]
Aziz K, Berger K, Claycombe K, Huang R, Patel R, Abela GS. Noninvasive detection and localization of vulnerable plaque and arterial thrombosis with computed tomography angiography/positron emission tomography. Circulation 2008; 117(16): 2061-70.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.106.652313] [PMID: 18391115]
[56]
Tawakol A, Migrino RQ, Bashian GG, et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 2006; 48(9): 1818-24.
[http://dx.doi.org/10.1016/j.jacc.2006.05.076] [PMID: 17084256]
[57]
Tawakol A, Migrino RQ, Hoffmann U, et al. Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography. J Nucl Cardiol 2005; 12(3): 294-301.
[http://dx.doi.org/10.1016/j.nuclcard.2005.03.002] [PMID: 15944534]
[58]
Rudd JH, Warburton EA, Fryer TD, et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002; 105(23): 2708-11.
[http://dx.doi.org/10.1161/01.CIR.0000020548.60110.76] [PMID: 12057982]
[59]
Gasecki AP, Eliasziw M, Ferguson GG, Hachinski V, Barnett HJ. North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group. Long-term prognosis and effect of endarterectomy in patients with symptomatic severe carotid stenosis and contralateral carotid stenosis or occlusion: results from NASCET. J Neurosurg 1995; 83(5): 778-82.
[http://dx.doi.org/10.3171/jns.1995.83.5.0778] [PMID: 7472542]
[60]
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA 1995; 273(18): 1421-8.
[61]
Norata GD, Garlaschelli K, Grigore L, et al. Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles. Atherosclerosis 2010; 208(1): 177-82.
[http://dx.doi.org/10.1016/j.atherosclerosis.2009.06.023] [PMID: 19619878]
[62]
Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P. Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126(3)(Suppl.): 483S-512S.
[http://dx.doi.org/10.1378/chest.126.3_suppl.483S] [PMID: 15383482]
[63]
Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002; 324(7329): 71-86.
[http://dx.doi.org/10.1136/bmj.324.7329.71] [PMID: 11786451]
[64]
Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. The SALT Collaborative Group Lancet 1991; 338(8779): 1345-9.
[65]
Algra A, van Gijn J. Aspirin at any dose above 30 mg offers only modest protection after cerebral ischaemia. J Neurol Neurosurg Psychiatry 1996; 60(2): 197-9.
[http://dx.doi.org/10.1136/jnnp.60.2.197] [PMID: 8708654]
[66]
van Gijn J, Algra A, Kappelle J, Koudstaal PJ, van Latum A. Dutch TIA Trial Study Group. A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke. N Engl J Med 1991; 325(18): 1261-6.
[http://dx.doi.org/10.1056/NEJM199110313251801] [PMID: 1922220]
[67]
Taylor DW, Barnett HJ, Haynes RB, et al. Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial. ASA and Carotid Endarterectomy (ACE) Trial Collaborators. Lancet 1999; 353(9171): 2179-84.
[http://dx.doi.org/10.1016/S0140-6736(99)05388-X] [PMID: 10392981]
[68]
Uchiyama S. Aspirin for primary stroke prevention in elderly patients with vascular risk factors. J Gen Fam Med 2017; 18(6): 331-5.
[http://dx.doi.org/10.1002/jgf2.102] [PMID: 29264061]
[69]
Secondary prevention of vascular disease by prolonged antiplatelet treatment. Antiplatelet Trialists' Collaboration Br Med J (Clin Res Ed) 1988; 296(6618): 320-31.
[70]
Hobson RW II, Krupski WC, Weiss DG. VA Cooperative Study Group on Asymptomatic Carotid Stenosis Influence of aspirin in the management of asymptomatic carotid artery stenosis J Vasc Surg 1993; 17(2): 257-63.
[http://dx.doi.org/10.1016/0741-5214(93)90411-E] [PMID: 8433421]
[71]
Patrono C, García Rodríguez LA, Landolfi R, Baigent C. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med 2005; 353(22): 2373-83.
[http://dx.doi.org/10.1056/NEJMra052717] [PMID: 16319386]
[72]
Meschia JF, Bushnell C, Boden-Albala B, et al. American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Functional Genomics and Translational Biology; Council on Hypertension. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014; 45(12): 3754-832.
[http://dx.doi.org/10.1161/STR.0000000000000046] [PMID: 25355838]
[73]
Committee CS. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348(9038): 1329-39.
[http://dx.doi.org/10.1016/S0140-6736(96)09457-3] [PMID: 8918275]
[74]
Hirsh J, Bhatt DL. Comparative benefits of clopidogrel and aspirin in high-risk patient populations: lessons from the CAPRIE and CURE studies. Arch Intern Med 2004; 164(19): 2106-10.
[http://dx.doi.org/10.1001/archinte.164.19.2106] [PMID: 15505123]
[75]
Markus HS, Droste DW, Kaps M, et al. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial. Circulation 2005; 111(17): 2233-40.
[http://dx.doi.org/10.1161/01.CIR.0000163561.90680.1C] [PMID: 15851601]
[76]
Bhatt DL, Flather MD, Hacke W, et al. CHARISMA Investigators. Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. J Am Coll Cardiol 2007; 49(19): 1982-8.
[http://dx.doi.org/10.1016/j.jacc.2007.03.025] [PMID: 17498584]
[77]
Bhatt DL, Fox KA, Hacke W, et al. CHARISMA Investigators. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 2006; 354(16): 1706-17.
[http://dx.doi.org/10.1056/NEJMoa060989] [PMID: 16531616]
[78]
Paciaroni M, Bogousslavsky J. Antithrombotic therapy in carotid artery stenosis: an update. Eur Neurol 2015; 73(1-2): 51-6.
[http://dx.doi.org/10.1159/000367988] [PMID: 25402664]
[79]
Diener HC, Bogousslavsky J, Brass LM, et al. Management of atherothrombosis with clopidogrel in high-risk patients with recent transient ischaemic attack or ischaemic stroke (MATCH): study design and baseline data. Cerebrovasc Dis 2004; 17(2-3): 253-61.
[http://dx.doi.org/10.1159/000076962] [PMID: 14981346]
[80]
Illuminati G, Schneider F, Pizzardi G, Masci F, Calio’ FG, Ricco JB. Dual Antiplatelet Therapy Does Not Increase the Risk of Bleeding After Carotid Endarterectomy: Results of a Prospective Study. Ann Vasc Surg 2017; 40: 39-43.
[http://dx.doi.org/10.1016/j.avsg.2016.09.012] [PMID: 28161565]
[81]
Barboza MA, Chang J, Hernández A, et al. Safety of Dual Antiplatelet Therapy After Carotid Endarterectomy for Prevention of Restenosis: A Single Center Experience. J Vasc Interv Neurol 2016; 9(2): 5-9.
[PMID: 27829964]
[82]
Wallentin L, Becker RC, Budaj A, et al. PLATO Investigators. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009; 361(11): 1045-57.
[http://dx.doi.org/10.1056/NEJMoa0904327] [PMID: 19717846]
[83]
Bellemain-Appaix A, Brieger D, Beygui F, et al. New P2Y12 inhibitors versus clopidogrel in percutaneous coronary intervention: a meta-analysis. J Am Coll Cardiol 2010; 56(19): 1542-51.
[http://dx.doi.org/10.1016/j.jacc.2010.07.012] [PMID: 20800407]
[84]
Amarenco P, Albers GW, Denison H, et al. SOCRATES Steering Committee and Investigators. Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial. Lancet Neurol 2017; 16(4): 301-10.
[http://dx.doi.org/10.1016/S1474-4422(17)30038-8] [PMID: 28238711]
[85]
Amarenco P, Albers GW, Denison H, et al. SOCRATES Steering Committee and Investigators. Ticagrelor Versus Aspirin in Acute Embolic Stroke of Undetermined Source. Stroke 2017; 48(9): 2480-7.
[http://dx.doi.org/10.1161/STROKEAHA.117.017217] [PMID: 28720658]
[86]
Sandercock PA, Counsell C, Kane EJ. Anticoagulants for acute ischaemic stroke. Cochrane Database Syst Rev 2015; (3): CD000024
[http://dx.doi.org/10.1002/14651858.CD000024.pub4] [PMID: 25764172]
[87]
Hoffman M. Remodeling the blood coagulation cascade. J Thromb Thrombolysis 2003; 16(1-2): 17-20.
[http://dx.doi.org/10.1023/B:THRO.0000014588.95061.28] [PMID: 14760207]
[88]
Connolly SJ, Ezekowitz MD, Yusuf S, et al. RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361(12): 1139-51.
[http://dx.doi.org/10.1056/NEJMoa0905561] [PMID: 19717844]
[89]
Lin L, Lim WS, Zhou HJ, et al. Clinical and Safety Outcomes of Oral Antithrombotics for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Network Meta-analysis. J Am Med Dir Assoc 2015; 16(12): e1101-1103.
[90]
Morais J, De Caterina R. Stroke Prevention in Atrial Fibrillation: A Clinical Perspective on Trials of the Novel Oral Anticoagulants. Cardiovasc Drugs Ther 2016; 30(2): 201-14.
[http://dx.doi.org/10.1007/s10557-015-6632-3] [PMID: 26780749]
[91]
Zhou X, Wu W, Chu L, Gutstein DE, Seiffert D, Wang X. Apixaban Inhibits Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits. J Pharmacol Exp Ther 2016; 358(3): 405-12.
[http://dx.doi.org/10.1124/jpet.116.234575] [PMID: 27384071]
[92]
Patel MR, Mahaffey KW, Garg J, et al. ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011; 365(10): 883-91.
[http://dx.doi.org/10.1056/NEJMoa1009638] [PMID: 21830957]
[93]
Mega JL, Braunwald E, Wiviott SD, et al. ATLAS ACS 2–TIMI 51 Investigators. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med 2012; 366(1): 9-19.
[http://dx.doi.org/10.1056/NEJMoa1112277] [PMID: 22077192]
[94]
Bosch J, Eikelboom JW, Connolly SJ, et al. Rationale, Design and Baseline Characteristics of Participants in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) Trial. Can J Cardiol 2017; 33(8): 1027-35.
[http://dx.doi.org/10.1016/j.cjca.2017.06.001] [PMID: 28754388]
[95]
Anand SS, Bosch J, Eikelboom JW, et al. COMPASS Investigators. Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. Lancet 2018; 391(10117): 219-29.
[http://dx.doi.org/10.1016/S0140-6736(17)32409-1] [PMID: 29132880]
[96]
Ay H, Gungor L, Arsava EM, et al. A score to predict early risk of recurrence after ischemic stroke. Neurology 2010; 74(2): 128-35.
[http://dx.doi.org/10.1212/WNL.0b013e3181ca9cff] [PMID: 20018608]
[97]
Flaherty ML, Flemming KD, McClelland R, Jorgensen NW, Brown RD Jr. Population-based study of symptomatic internal carotid artery occlusion: incidence and long-term follow-up. Stroke 2004; 35(8): e349-52.
[http://dx.doi.org/10.1161/01.STR.0000135024.54608.3f] [PMID: 15232124]
[98]
Nehler MR, Moneta GL, McConnell DB, et al. Anticoagulation followed by elective carotid surgery in patients with repetitive transient ischemic attacks and high-grade carotid stenosis. Arch Surg 1993; 128(10): 1117-21.
[http://dx.doi.org/10.1001/archsurg.1993.01420220037005] [PMID: 8215872]
[99]
Hinse P, Thie A, Lachenmayer L. Dissection of the extracranial vertebral artery: report of four cases and review of the literature. J Neurol Neurosurg Psychiatry 1991; 54(10): 863-9.
[http://dx.doi.org/10.1136/jnnp.54.10.863] [PMID: 1744639]
[100]
Thanvi B, Munshi SK, Dawson SL, Robinson TG. Carotid and vertebral artery dissection syndromes. Postgrad Med J 2005; 81(956): 383-8.
[http://dx.doi.org/10.1136/pgmj.2003.016774] [PMID: 15937204]
[101]
Koennecke HC, Trocio SH Jr, Mast H, Mohr JP. Microemboli on transcranial Doppler in patients with spontaneous carotid artery dissection. J Neuroimaging 1997; 7(4): 217-20.
[http://dx.doi.org/10.1111/jon199774217] [PMID: 9344003]
[102]
Markus HS, Levi C, King A, Madigan J, Norris J. Cervical Artery Dissection in Stroke Study (CADISS) Investigators. Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results. JAMA Neurol 2019; 76(6): 657-64.
[http://dx.doi.org/10.1001/jamaneurol.2019.0072] [PMID: 30801621]
[103]
Kasner SE. CADISS: a feasibility trial that answered its question. Lancet Neurol 2015; 14(4): 342-3.
[http://dx.doi.org/10.1016/S1474-4422(14)70271-6] [PMID: 25684165]
[104]
Norris JW. Extracranial arterial dissection: anticoagulation is the treatment of choice: for. Stroke 2005; 36(9): 2041-2.
[http://dx.doi.org/10.1161/01.STR.0000177504.72886.6b] [PMID: 16109912]
[105]
Redekop GJ. Extracranial carotid and vertebral artery dissection: a review. Can J Neurol Sci 2008; 35(2): 146-52.
[http://dx.doi.org/10.1017/s0317167100008556] [PMID: 18574926]
[106]
Menon R, Kerry S, Norris JW, Markus HS. Treatment of cervical artery dissection: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry 2008; 79(10): 1122-7.
[http://dx.doi.org/10.1136/jnnp.2007.138800] [PMID: 18303104]
[107]
Bae HJ, Debette S. Commentary on the Cervical Artery Dissection in Stroke Study Trial. Stroke 2016; 47(5): 1413-5.
[http://dx.doi.org/10.1161/STROKEAHA.115.011516] [PMID: 27048699]
[108]
Adams HP Jr, Davis PH, Leira EC, et al. Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology 1999; 53(1): 126-31.
[http://dx.doi.org/10.1212/wnl.53.1.126] [PMID: 10408548]
[109]
Schoenefeld E, Donas K, Radicke A, Osada N, Austermann M, Torsello G. Perioperative use of aspirin for patients undergoing carotid endarterectomy. Vasa 2012; 41(4): 282-7.
[http://dx.doi.org/10.1024/0301-1526/a000204] [PMID: 22825862]
[110]
Diener HC, Bogousslavsky J, Brass LM, et al. MATCH investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 2004; 364(9431): 331-7.
[http://dx.doi.org/10.1016/S0140-6736(04)16721-4] [PMID: 15276392]
[111]
Eikelboom JW, Connolly SJ, Bosch J, et al. COMPASS Investigators. Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease. N Engl J Med 2017; 377(14): 1319-30.
[http://dx.doi.org/10.1056/NEJMoa1709118] [PMID: 28844192]

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