Background: Parkinson’s disease is a common neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta.
Introduction: The effects of alpha synuclein, parkin mutation and pharmacological agents have been studied in the Drosophila model.
Method: The effect of cabergoline was studied on the cognitive impairments exhibited by the transgenic Drosophila expressing human alpha-synuclein in the neurons. The PD flies were allowed to feed on the diet having 0.5, 1 and 1.5 μM of
Result: The exposure of cabergoline not only showed a dose-dependent significant delay in the cognitive impairments but
also prevented the loss of dopaminergic neurons. Molecular docking studies showed the positive interaction between
cabergoline and alpha-synuclein.
Conclusion: The results suggest a protective effect of cabergoline against the cognitive impairments.