Login Register Cart 0
Generic placeholder image

Current Women`s Health Reviews

Editor-in-Chief

ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Polycystic Ovary Syndrome Affects Age-associated Health-Related Quality of Life Among Young Age Women in the Urban-Rural Population

Author(s): Fauzia Tabassum*, Kavita Dhar, Hemali Heidi Sinha, Chandra Jyoti, Md Sayeed Akhtar and Vipender S. Chopra

Volume 16, Issue 3, 2020

Page: [244 - 250] Pages: 7

DOI: 10.2174/1573404816999200511103456

Price: $65

Abstract

Background: Polycystic ovary syndrome (PCOS) is the major endocrine disorder in women that promptly affects psychological perception and associated social and cultural relations with women. Health-related quality of life (HRQOL) was assessed to explore the effects of PCOS in terms of emotional aspects and related anxiety in women.

Objective: The purpose of this study was to explore the psychological burden in adolescent women due to PCOS.

Methods: A prospective questionnaire-based study was conducted at a tertiary care hospital, and 100 PCOS and 200 healthy cases were enrolled based on Rotterdam criteria during the year 2017 and 2018. Pre-validated HRQOL questionnaires like Short Form Health survey-36 (SF-36) were used for evaluating the impact of PCOS in women.

Results: In PCOS cases, mean age and body mass index was 22.81±5.33 and 24.35±5.49 respectively. A significant difference (P=0.001) regarding age was observed between PCOS and healthy control. The higher percentage of PCOS cases (90 %) were among the category of less than 5 years of PCOS symptoms. In addition, we observed a significant (P=0.001) reduction in quality of life in all eight domains of SF-36 questionnaire between PCOS and healthy control cases. Moreover, a decreasing pattern of SF-36 score was observed with an increase in the duration of PCOS symptoms.

Conclusion: Altogether, our result of this study concluded that HRQOL especially emotional changes were more affected in adolescent and middle age group patients that may be due to fear of infertility and cosmetic problems.

Keywords: PCOS, HRQOL, infertility, endocrine disorder, cosmetic, adolescent patients.

Graphical Abstract

[1]
Colwell HH, Mathias SD, Pasta DJ, Henning JM, Steege JF. A health-related quality-of-life instrument for symptomatic patients with endometriosis: a validation study. Am J Obstet Gynecol 1998; 179(1): 47-55.
[http://dx.doi.org/10.1016/S0002-9378(98)70250-9] [PMID: 9704764]
[2]
Stracquadanio M, Ciotta L. Metabolic Aspects of PCOS: Treatment with Insulin Sensitizers. Switzerland: Springer International Publishing 2015.
[http://dx.doi.org/10.1007/978-3-319-16760-2]
[3]
Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol 2013; 6: 1-13.
[http://dx.doi.org/10.2147/CLEP.S37559] [PMID: 24379699]
[4]
Fauser BC, Tarlatzis BC, Rebar RW, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 2012; 97(1): 28-38.e25.
[http://dx.doi.org/10.1016/j.fertnstert.2011.09.024] [PMID: 22153789]
[5]
Teede H, Deeks A, Moran L. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med 2010; 8: 41.https://bmcmedicine.biomedcentral.com/articles/ 10.1186/1741-7015-8-41
[http://dx.doi.org/10.1186/1741-7015-8-41] [PMID: 20591140]
[6]
Ajmal N, Khan SZ, Shaikh R. Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article Eur J Obstet Gynecol Reprod Biol X 2019; 8(3): 100060 https://www.sciencedirect.com/science/article/pii/S2590161319300948?via%3Dihub
[7]
Behboudi-Gandevani S, Amiri M, Bidhendi Yarandi R, et al. The risk of metabolic syndrome in polycystic ovary syndrome: A systematic review and meta-analysis. Clin Endocrinol (Oxf) 2018; 88(2): 169-84.
[http://dx.doi.org/10.1111/cen.13477] [PMID: 28930378]
[8]
Ramezani Tehrani F, Montazeri SA, Hosseinpanah F, et al. Trend of cardio-metabolic risk factors in polycystic ovary syndrome: A population-based prospective cohort study. PLoS One 2015; 10(9):e0137609.
[http://dx.doi.org/10.1371/journal.pone.0137609] [PMID: 26360602]
[9]
Kazemi Jaliseh H, Ramezani Tehrani F, Behboudi-Gandevani S, et al. Polycystic ovary syndrome is a risk factor for diabetes and prediabetes in middle-aged but not elderly women: a long-term population-based follow-up study. Fertil Steril 2017; 108(6): 1078-84.
[http://dx.doi.org/10.1016/j.fertnstert.2017.09.004] [PMID: 29202960]
[10]
Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19(1): 41-7.
[http://dx.doi.org/10.1093/humrep/deh098] [PMID: 14688154]
[11]
Moran LJ, Norman RJ, Teede HJ. Metabolic risk in PCOS: phenotype and adiposity impact. Trends Endocrinol Metab 2015; 26(3): 136-43.
[http://dx.doi.org/10.1016/j.tem.2014.12.003] [PMID: 25591984]
[12]
Veltman-Verhulst SM, Boivin J, Eijkemans MJ, Fauser BJ. Emotional distress is a common risk in women with polycystic ovary syndrome: a systematic review and meta-analysis of 28 studies. Hum Reprod Update 2012; 18(6): 638-51.
[http://dx.doi.org/10.1093/humupd/dms029] [PMID: 22824735]
[13]
Li Y, Li Y, Yu Ng EH, et al. Polycystic ovary syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from a meta-analysis. Fertil Steril 2011; 96(2): 452-8.
[http://dx.doi.org/10.1016/j.fertnstert.2011.05.072] [PMID: 21703610]
[14]
Khadilkar SS. Polycystic ovarian syndrome: is it time to rename PCOS to HA-PODS? J Obstet Gynaecol India 2016; 66(2): 81-7.
[http://dx.doi.org/10.1007/s13224-016-0851-9] [PMID: 27046960]
[15]
Taghavi SA, Bazarganipour F, Hugh-Jones S, Hosseini N. Health-related quality of life in Iranian women with polycystic ovary syndrome: a qualitative study. BMC Womens Health 2015; 15: 111.
[http://dx.doi.org/10.1186/s12905-015-0272-4] [PMID: 26620588]
[16]
Sharif E, Rahman S, Zia Y, Rizk NM. The frequency of polycystic ovary syndrome in young reproductive females in Qatar. Int J Womens Health 2016; 9: 1-10.
[http://dx.doi.org/10.2147/IJWH.S120027] [PMID: 28031728]
[17]
Angin P, Yoldemir T, Atasayan K. Quality of life among infertile PCOS patients. Arch Gynecol Obstet 2019; 300(2): 461-7.
[http://dx.doi.org/10.1007/s00404-019-05202-z] [PMID: 31172306]
[18]
Ware JE Jr, Kosinski M, Gandek B, et al. The factor structure of the SF-36 health surveys in 10 countries: Result from the international quality of life assessment (IQOLA) project. J Clin Epidemiol 1998; 51(11): 1159-65.
[http://dx.doi.org/10.1016/S0895-4356(98)00107-3] [PMID: 9817133]
[19]
Brazier JE, Harper R, Jones NM, et al. Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ 1992; 305(6846): 160-4.
[http://dx.doi.org/10.1136/bmj.305.6846.160] [PMID: 1285753]
[20]
BAttcher B, Fessler S, Friedl F, et al. Health-related quality of life in patients with polycystic ovary syndrome: validation of the German PCOSQ-G. Arch Gynecol Obstet 2018; 297(4): 1027-35.
[http://dx.doi.org/10.1007/s00404-017-4623-2] [PMID: 29249009]
[21]
Rodin DA, Bano G, Bland JM, Taylor K, Nussey SS. Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women. Clin Endocrinol (Oxf) 1998; 49(1): 91-9.
[http://dx.doi.org/10.1046/j.1365-2265.1998.00492.x] [PMID: 9797852]
[22]
Clayton RN, Ogden V, Hodgkinson J, et al. How common are polycystic ovaries in normal women and what is their significance for the fertility of the population? Clin Endocrinol (Oxf) 1992; 37(2): 127-34.
[http://dx.doi.org/10.1111/j.1365-2265.1992.tb02296.x] [PMID: 1395063]
[23]
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27(5): 1047-53.
[http://dx.doi.org/10.2337/diacare.27.5.1047] [PMID: 15111519]
[24]
Wang F, Dai W, Yang XH, Guo YH, Sun YP. Analyses of optimal body mass index for infertile patients with either polycystic or non-polycystic ovary syndrome during assisted reproductive treatment in China. Sci Rep 2016; 6: 34538.
[http://dx.doi.org/10.1038/srep34538] [PMID: 27686055]
[25]
Ewens KG, Stewart DR, Ankener W, et al. Family-based analysis of candidate genes for polycystic ovary syndrome. J Clin Endocrinol Metab 2010; 95(5): 2306-15.
[http://dx.doi.org/10.1210/jc.2009-2703] [PMID: 20200332]
[26]
Barrett ES, Hoeger KM, Sathyanarayana S, et al. Anogenital distance in newborn daughters of women with polycystic ovary syndrome indicates fetal testosterone exposure. J Dev Orig Health Dis 2018; 9(3): 307-14.
[http://dx.doi.org/10.1017/S2040174417001118] [PMID: 29310733]
[27]
Hahn S, Janssen OE, Tan S, et al. Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome. Eur J Endocrinol 2005; 153(6): 853-60.
[http://dx.doi.org/10.1530/eje.1.02024] [PMID: 16322391]
[28]
Elsenbruch S, Hahn S, Kowalsky D, et al. Quality of life, psychosocial well-being, and sexual satisfaction in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2003; 88(12): 5801-7.
[http://dx.doi.org/10.1210/jc.2003-030562] [PMID: 14671172]
[29]
Ching HL, Burke V, Stuckey BG. Quality of life and psychological morbidity in women with polycystic ovary syndrome: body mass index, age and the provision of patient information are significant modifiers. Clin Endocrinol (Oxf) 2007; 66(3): 373-9.
[http://dx.doi.org/10.1111/j.1365-2265.2007.02742.x] [PMID: 17302871]
[30]
Coffey S, Bano G, Mason HD. Health-related quality of life in women with PCOS: A comparison with the general population using the PCOSQ and the SF-36. Gynecol Endocrinol 2006; 22: 80-6.
[http://dx.doi.org/10.1080/09513590600604541] [PMID: 16603432]
[31]
Behboodi Moghadam Z, Fereidooni B, Saffari M, Montazeri A. Measures of health-related quality of life in PCOS women: a systematic review. Int J Womens Health 2018; 10: 397-408.
[http://dx.doi.org/10.2147/IJWH.S165794] [PMID: 30123008]
[32]
Hashimoto DM, Schmid J, Martins FM, et al. The impact of the weight status on subjective symptomatology of the Polycystic Ovary Syndrome: a cross-cultural comparison between Brazilian and Austrian women. Anthropol Anz 2003; 61(3): 297-310.
[http://dx.doi.org/10.1127/anthranz/61/2003/297] [PMID: 14524003]
[33]
Castilla C. Political role models and child marriage in India. Rev Dev Econ 2018; 22: 1409-31.
[http://dx.doi.org/10.1111/rode.12513]
[34]
World health organisationDepression 2019; Available from: https://www.who.int/news-room/fact-sheets/detail/depression (Accessed on: Jan 17, 2020).
[35]
Alur-Gupta S, Chemerinski A, Liu C, et al. Body-image distress is increased in women with polycystic ovary syndrome and mediates depression and anxiety. Fertil Steril 2019; 112(5): 930-938.e1.
[http://dx.doi.org/10.1016/j.fertnstert.2019.06.018] [PMID: 31395311]

Rights & Permissions Print Cite
Article Metrics
7
© 2024 Bentham Science Publishers | Privacy Policy