Generic placeholder image

Current Cardiology Reviews

Editor-in-Chief

ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Review Article

Association between Omentin-1 and Coronary Artery Disease: Pathogenesis and Clinical Research

Author(s): Lutfu Askin*, Hakan Duman, Ali Ozyıldız, Okan Tanriverdi and Serdar Turkmen

Volume 16, Issue 3, 2020

Page: [198 - 201] Pages: 4

DOI: 10.2174/1573403X16666200511085304

Price: $65

Abstract

Like other adipokines, omentin-1 is secreted from visceral adipose tissue and plays a vital role in the development of chronic inflammatory diseases, including cardiovascular events. Recent studies have shown that circulating omentin-1 levels are associated with various metabolic risk factors, such as high blood pressure, increased waist circumference, dyslipidemia, and glucose intolerance. The decrease in serum omentin level is an independent predictor of Coronary Artery Disease (CAD) and is associated with the severity of this disease. Since there is no relevant review in the literature, we aimed to summarize the studies on the relationship between omentin-1 and CAD.

Keywords: Acute coronary syndrome, coronary artery disease, omentin-1, vascular smooth muscle cell, adipokines, adipose tissues.

Graphical Abstract
[1]
Saely CH, Leiherer A, Muendlein A, et al. Coronary patients with high plasma omentin are at a higher cardiovascular risk. Data Brief 2015; 6: 158-61.
[http://dx.doi.org/10.1016/j.dib.2015.11.065] [PMID: 26862554]
[2]
Schäffler A, Neumeier M, Herfarth H, et al. Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochim Biophys Acta 2005; 1732(1-3): 96-102.
[http://dx.doi.org/10.1016/j.bbaexp.2005.11.005] [PMID: 16386808]
[3]
Yang RZ, Lee MJ, Hu H, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: Possible role in modulating insulin action. Am J Physiol Endocrinol Metab 2006; 290(6): E1253-61.
[http://dx.doi.org/10.1152/ajpendo.00572.2004] [PMID: 16531507]
[4]
Kocijancic M, Vujicic B, Racki S, Cubranic Z, Zaputovic L, Dvornik S. Serum omentin-1 levels as a possible risk factor of mortality in patients with diabetes on haemodialysis. Diabetes Res Clin Pract 2015; 110(1): 44-50.
[http://dx.doi.org/10.1016/j.diabres.2015.06.008] [PMID: 26293449]
[5]
Onur I, Oz F, Yildiz S, et al. A decreased serum omentin-1 level may be an independent risk factor for peripheral arterial disease. Int Angiol 2014; 33(5): 455-60.
[PMID: 25294287]
[6]
Shang FJ, Wang JP, Liu XT, et al. Serum omentin-1 levels are inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome. Biomarkers 2011; 16(8): 657-62.
[http://dx.doi.org/10.3109/1354750X.2011.622789] [PMID: 21988056]
[7]
Kadoglou NP, Tahmatzidis DK, Giannakoulas C, et al. Serum levels of novel adipokines, omentin-1 and chemerin, in patients with acute myocardial infarction: KOZANI STUDY. J Cardiovasc Med (Hagerstown) 2015; 16(5): 341-6.
[http://dx.doi.org/10.2459/JCM.0000000000000053] [PMID: 25022935]
[8]
de Souza Batista CM, Yang RZ, Lee MJ, et al. Omentin plasma levels and gene expression are decreased in obesity. Diabetes 2007; 56(6): 1655-61.
[http://dx.doi.org/10.2337/db06-1506] [PMID: 17329619]
[9]
Stejskal D, Vaclavik J, Smekal A, Svobodova G, Richterova R, Svestak M. Omentin-1 levels in patients with premature coronary artery disease, metabolic syndrome and healthy controls. Short communication. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2016; 160(2): 219-21.
[http://dx.doi.org/10.5507/bp.2016.019] [PMID: 27108603]
[10]
Shibata R, Ouchi N, Takahashi R, et al. Omentin as a novel biomarker of metabolic risk factors. Diabetol Metab Syndr 2012; 4(1): 37.
[http://dx.doi.org/10.1186/1758-5996-4-37] [PMID: 22835063]
[11]
Yoo HJ, Hwang SY, Hong HC, et al. Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes. Cardiovasc Diabetol 2011; 10: 103.
[http://dx.doi.org/10.1186/1475-2840-10-103] [PMID: 22108456]
[12]
Jung CH, Jung SH, Kim BY, Kim CH, Kang SK, Mok JO. Association of serum omentin levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A hospital-based study. Cardiovasc Diabetol 2015; 14: 140.
[http://dx.doi.org/10.1186/s12933-015-0303-3] [PMID: 26466574]
[13]
Shibata R, Ouchi N, Kikuchi R, et al. Circulating omentin is associated with coronary artery disease in men. Atherosclerosis 2011; 219(2): 811-4.
[http://dx.doi.org/10.1016/j.atherosclerosis.2011.08.017] [PMID: 21925659]
[14]
Saely CH, Leiherer A, Muendlein A, et al. High plasma omentin predicts cardiovascular events independently from the presence and extent of angiographically determined atherosclerosis. Atherosclerosis 2016; 244: 38-43.
[http://dx.doi.org/10.1016/j.atherosclerosis.2015.10.100] [PMID: 26590865]
[15]
Kocijancic M, Cubranic Z, Vujicic B, Racki S, Dvornik S, Zaputovic L. Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients. Int Urol Nephrol 2016; 48(7): 1145-54.
[http://dx.doi.org/10.1007/s11255-016-1275-2] [PMID: 27023478]
[16]
Narumi T, Watanabe T, Kadowaki S, et al. Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure. Cardiovasc Diabetol 2014; 13: 84.
[http://dx.doi.org/10.1186/1475-2840-13-84] [PMID: 24755035]
[17]
Gaborit B, Venteclef N, Ancel P, et al. Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location. Cardiovasc Res 2015; 108(1): 62-73.
[http://dx.doi.org/10.1093/cvr/cvv208] [PMID: 26239655]
[18]
Du Y, Ji Q, Cai L, et al. Association between omentin-1 expression in human epicardial adipose tissue and coronary atherosclerosis. Cardiovasc Diabetol 2016; 15: 90.
[http://dx.doi.org/10.1186/s12933-016-0406-5] [PMID: 27352781]
[19]
Verhagen SN, Buijsrogge MP, Vink A, van Herwerden LA, van der Graaf Y, Visseren FL. Secretion of adipocytokines by perivascular adipose tissue near stenotic and non-stenotic coronary artery segments in patients undergoing CABG. Atherosclerosis 2014; 233(1): 242-7.
[http://dx.doi.org/10.1016/j.atherosclerosis.2013.12.005] [PMID: 24529151]
[20]
Iacobellis G, Corradi D, Sharma AM. Epicardial adipose tissue: Anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med 2005; 2(10): 536-43.
[http://dx.doi.org/10.1038/ncpcardio0319] [PMID: 16186852]
[21]
Cheng KH, Chu CS, Lee KT, et al. Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease. Int J Obes 2008; 32(2): 268-74.
[http://dx.doi.org/10.1038/sj.ijo.0803726] [PMID: 17878891]
[22]
Yang R-Z, Lee M-J, Hu H, et al. Identification of omentin as a novel depotspecific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 2006; 290: 1253-61.
[http://dx.doi.org/10.1152/ajpendo.00572.2004]
[23]
Greulich S, Chen WJ, Maxhera B, et al. Cardioprotective properties of omentin-1 in type 2 diabetes: Evidence from clinical and in vitro studies. PLoS One 2013; 8(3)e59697
[http://dx.doi.org/10.1371/journal.pone.0059697] [PMID: 23555749]
[24]
Watanabe K, Watanabe R, Konii H, et al. Counteractive effects of omentin-1 against atherogenesis. Cardiovasc Res 2016; 110(1): 118-28.
[http://dx.doi.org/10.1093/cvr/cvw016] [PMID: 26790473]
[25]
Hiramatsu-Ito M, Shibata R, Ohashi K, et al. Abstract 11475: overexpression of human omentin in a fat-specific manner attenuates atherosclerotic lesion formation in apoe-deficient mice. Circulation 2014; 130A11475
[http://dx.doi.org/10.1161/circ.130.suppl_2.11475]
[26]
Zhou Y, Zhang B, Hao C, et al. Omentin-A Novel Adipokine in Respiratory Diseases. Int J Mol Sci 2017; 19(1)E73
[http://dx.doi.org/10.3390/ijms19010073] [PMID: 29283409]
[27]
Yamawaki H, Kuramoto J, Kameshima S, Usui T, Okada M, Hara Y. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Biochem Biophys Res Commun 2011; 408(2): 339-43.
[http://dx.doi.org/10.1016/j.bbrc.2011.04.039] [PMID: 21514279]
[28]
Kazama K, Usui T, Okada M, Hara Y, Yamawaki H. Omentin plays an anti-inflammatory role through inhibition of TNF-α-induced superoxide production in vascular smooth muscle cells. Eur J Pharmacol 2012; 686(1-3): 116-23.
[http://dx.doi.org/10.1016/j.ejphar.2012.04.033] [PMID: 22554771]
[29]
Jha CK, Mir R, Elfaki I, et al. Evaluation of the association of omentin 1 rs2274907 A>T and rs2274908 G>A gene polymorphisms with coronary artery disease in indian population: A case control study. J Pers Med 2019; 9(2): 9.
[http://dx.doi.org/10.3390/jpm9020030] [PMID: 31174318]
[30]
Jamshidi J, Ghanbari M, Asnaashari A, Jafari N, Valizadeh GA. Omentin Val109Asp polymorphism and risk of coronary artery disease. Asian Cardiovasc Thorac Ann 2017; 25(3): 199-203.
[http://dx.doi.org/10.1177/0218492317699752] [PMID: 28325076]
[31]
Nazar S, Zehra S, Azhar A. Association of single Nucleotide Missence Polymorphism Val109Asp of Omentin-1 gene and coronary artery disease in Pakistani population: Multicenter study. Pak J Med Sci 2017; 33(5): 1128-33.
[PMID: 29142551]
[32]
Elsaid NH, Sadik NA, Ahmed NR, Fayez SE, Mohammed NAE. Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters. J Clin Transl Endocrinol 2018; 13: 14-9.
[http://dx.doi.org/10.1016/j.jcte.2018.05.003] [PMID: 30023310]
[33]
Chen Q, Shang X, Yuan M, Liang L, Zhong X. Effect of atorvastatin on serum omentin-1 in patients with coronary artery disease. Coron Artery Dis 2017; 28(1): 44-51.
[http://dx.doi.org/10.1097/MCA.0000000000000435] [PMID: 27749321]
[34]
Alkuraishy HM, Al-Gareeb AI. New insights into the role of metformin effects on serum omentin-1 levels in acute myocardial infarction: Cross-sectional study. Emerg Med Int 2015; 2015283021
[http://dx.doi.org/10.1155/2015/283021] [PMID: 26682070]
[35]
Zhou JP, Tong XY, Zhu LP, et al. Plasma omentin-1 level as a predictor of good coronary collateral circulation. J Atheroscler Thromb 2017; 24(9): 940-8.
[http://dx.doi.org/10.5551/jat.37440] [PMID: 28123148]
[36]
Maruyama S, Shibata R, Kikuchi R, et al. Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism. J Biol Chem 2012; 287(1): 408-17.
[http://dx.doi.org/10.1074/jbc.M111.261818] [PMID: 22081609]
[37]
Takeda Y, Costa S, Delamarre E, et al. Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature 2011; 479(7371): 122-6.
[http://dx.doi.org/10.1038/nature10507] [PMID: 21983962]
[38]
De Jager SC, Pasterkamp G. Atheroprotective properties of human Omentin-1 in experimental atherosclerosis. Cardiovasc Res 2016; 110(1): 1-3.
[http://dx.doi.org/10.1093/cvr/cvw040] [PMID: 26935810]
[39]
Zhu Y, Hu C, Du Y, et al. Time-dependent change in omentin-1 level correlated with early improvement of myocardial function in patients with first anterior st-segment elevation myocardial infarction after primary percutaneous coronary intervention. J Atheroscler Thromb 2019; 26(10): 856-67.
[http://dx.doi.org/10.5551/jat.47043] [PMID: 30853697]
[40]
Tao S, Huang YQ, Cai AP, et al. Association of serum omentin-1 concentrations with the presence of atrial fibrillation. Med Sci Monit 2016; 22: 4749-54.
[http://dx.doi.org/10.12659/MSM.898202] [PMID: 27915353]
[41]
Onur I, Oz F, Yildiz S, et al. Serum omentin 1 level is associated with coronary artery disease and its severity in postmenopausal women. Angiology 2014; 65(10): 896-900.
[http://dx.doi.org/10.1177/0003319713511322] [PMID: 24265251]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy