Login Register Cart 0
Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Association Between sRAGE and Arterial Stiffness in Women with Systemic Lupus Erythematosus

Author(s): Hongru Wang, Yibin Zeng, Huan Zheng and Bin Liu*

Volume 21, Issue 3, 2021

Published on: 06 May, 2020

Page: [504 - 510] Pages: 7

DOI: 10.2174/1871530320666200506082848

Price: $65

Abstract

Background: sRAGE (soluble receptor for advanced glycation end products) is known to play a protective role in chronic inflammatory diseases, and has been found to be related to arterial stiffness in hypertensive or diabetic patients. This cross-sectional study was designed to study the potential association of sRAGE with arterial stiffness in systemic lupus erythematosus(SLE) patients.

Methods: A total of 94 female SLE patients were enrolled. Brachial-ankle pulse wave velocity (baPWV) was measured by an automatic pulse wave analyzer. The patients were divided into two groups according to the baPWV values, those with values greater than 1400cm/s were placed in the high arterial stiffness group. Biochemical parameters were compared between the two groups. Linear and logistic regression analysis was used to observe the association between sRAGE and arterial stiffness in these patients.

Results: Thirty-five patients were placed in the high arterial stiffness group in which sRAGE levels were lower (P<0.05). sRAGE levels were significantly related to baPWV(standardized β=1.18, P<0.01) by linear regression analysis. Multivariate logistic regression analysis showed that sRAGE, SLE duration, systolic blood pressure, and low-density lipoprotein cholesterol were independent predictors of arterial stiffness in these patients.

Conclusion: The results revealed that sRAGE was negatively associated with arterial stiffness in Chinese female SLE patients.

Keywords: sRAGE, arterial stiffness, systemic lupus erythematosus, brachial–ankle pulse wave velocity, advanced glycationend products, women.

« Previous Next »
Graphical Abstract

[1]
Teixeira, V.; Tam, L.S. Novel insights in systemic lupus erythematosus and atherosclerosis. Front. Med. (Lausanne), 2018, 4, 262.
[http://dx.doi.org/10.3389/fmed.2017.00262]
[2]
Magder, L.S.; Petri, M. Incidence of and risk factors for adverse cardiovascular events among patients with systemic lupus erythematosus. Am. J. Epidemiol., 2012, 176(8), 708-719.
[http://dx.doi.org/10.1093/aje/kws130] [PMID: 23024137]
[3]
Skaggs, B.J.; Hahn, B.H.; McMahon, M. Accelerated atherosclerosis in patients with SLE--mechanisms and management. Nat. Rev. Rheumatol., 2012, 8(4), 214-223.
[http://dx.doi.org/10.1038/nrrheum.2012.14] [PMID: 22331061]
[4]
O’rourke, M.F.; Franklin, S.S. Arterial stiffness: reflections on the arterial pulse. Eur. Heart J., 2006, 27(21), 2497-2498.
[http://dx.doi.org/10.1093/eurheartj/ehl312] [PMID: 17035251]
[5]
Yamashina, A.; Tomiyama, H.; Takeda, K.; Tsuda, H.; Arai, T.; Hirose, K.; Koji, Y.; Hori, S.; Yamamoto, Y. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens. Res., 2002, 25(3), 359-364.
[http://dx.doi.org/10.1291/hypres.25.359] [PMID: 12135313]
[6]
Satoh, H.; Kishi, R.; Tsutsui, H. Metabolic syndrome is a significant and independent risk factor for increased arterial stiffness in Japanese subjects. Hypertens. Res., 2009, 32(12), 1067-1071.
[http://dx.doi.org/10.1038/hr.2009.158] [PMID: 19779485]
[7]
Ohkuma, T.; Ninomiya, T.; Tomiyama, H.; Kario, K.; Hoshide, S.; Kita, Y.; Inoguchi, T.; Maeda, Y.; Kohara, K.; Tabara, Y.; Nakamura, M.; Ohkubo, T.; Watada, H.; Munakata, M.; Ohishi, M.; Ito, N.; Nakamura, M.; Shoji, T.; Vlachopoulos, C.; Yamashina, A. Brachial-ankle pulse wave velocity and the risk prediction of cardiovascular disease: an individual participant data meta-analysis. Hypertension, 2017, 69(6), 1045-1052.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09097] [PMID: 28438905]
[8]
Vlachopoulos, C.; Aznaouridis, K.; Terentes-Printzios, D.; Ioakeimidis, N.; Stefanadis, C. Prediction of cardiovascular events and all-cause mortality with brachial-ankle elasticity index: a systematic review and meta-analysis. Hypertension, 2012, 60(2), 556-562.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.194779] [PMID: 22733468]
[9]
Valero-Gonzalez, S.; Castejon, R.; Jimenez-Ortiz, C.; Rosado, S.; Tutor-Ureta, P.; Vargas, J.A.; Yebra-Bango, M. Increased arterial stiffness is independently associated with metabolic syndrome and damage index in systemic lupus erythematosus patients. Scand. J. Rheumatol., 2014, 43(1), 54-58.
[http://dx.doi.org/10.3109/03009742.2013.803150] [PMID: 24050535]
[10]
Maillard-Lefebvre, H.; Boulanger, E.; Daroux, M.; Gaxatte, C.; Hudson, B.I.; Lambert, M. Soluble receptor for advanced glycation end products: a new biomarker in diagnosis and prognosis of chronic inflammatory diseases. Rheumatology (Oxford), 2009, 48(10), 1190-1196.
[http://dx.doi.org/10.1093/rheumatology/kep199] [PMID: 19589888]
[11]
Dimitriadis, K.; Tsioufis, C.; Kasiakogias, A.; Miliou, A.; Poulakis, M.; Kintis, K.; Bafakis, I.; Benardis, E.; Tousoulis, D.; Stefanadis, C. Soluble receptor for advanced glycation end-product levels are related to albuminuria and arterial stiffness in essential hypertension. Nutr. Metab. Cardiovasc. Dis., 2013, 23(4), 382-388.
[http://dx.doi.org/10.1016/j.numecd.2011.10.003] [PMID: 22212601]
[12]
Mayer, O.; Seidlerová, J.; Filipovský, J.; Vágovičová, P.; Wohlfahrt, P.; Cífková, R.; Windrichová, J.; Topolčan, O. Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population. Hypertens. Res., 2016, 39(4), 266-271.
[http://dx.doi.org/10.1038/hr.2015.131] [PMID: 26631850]
[13]
Choi, K.M.; Yoo, H.J.; Kim, H.Y.; Lee, K.W.; Seo, J.A.; Kim, S.G.; Kim, N.H.; Choi, D.S.; Baik, S.H. Association between endogenous secretory RAGE, inflammatory markers and arterial stiffness. Int. J. Cardiol., 2009, 132(1), 96-101.
[http://dx.doi.org/10.1016/j.ijcard.2007.10.047] [PMID: 18190981]
[14]
Yamashina, A.; Tomiyama, H.; Arai, T.; Hirose, K.; Koji, Y.; Hirayama, Y.; Yamamoto, Y.; Hori, S. Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk. Hypertens. Res., 2003, 26(8), 615-622.
[http://dx.doi.org/10.1291/hypres.26.615] [PMID: 14567500]
[15]
Petri, M.; Kim, M.Y.; Kalunian, K.C.; Grossman, J.; Hahn, B.H.; Sammaritano, L.R.; Lockshin, M.; Merrill, J.T.; Belmont, H.M.; Askanase, A.D.; McCune, W.J.; Hearth-Holmes, M.; Dooley, M.A.; Von Feldt, J.; Friedman, A.; Tan, M.; Davis, J.; Cronin, M.; Diamond, B.; Mackay, M.; Sigler, L.; Fillius, M.; Rupel, A.; Licciardi, F.; Buyon, J.P. OC-SELENA Trial. Combined oral contraceptives in women with systemic lupus erythematosus. N. Engl. J. Med., 2005, 353(24), 2550-2558.
[http://dx.doi.org/10.1056/NEJMoa051135] [PMID: 16354891]
[16]
Gladman, D.; Ginzler, E.; Goldsmith, C.; Fortin, P.; Liang, M.; Urowitz, M.; Bacon, P.; Bombardieri, S.; Hanly, J.; Hay, E.; Isenberg, D.; Jones, J.; Kalunian, K.; Maddison, P.; Nived, O.; Petri, M.; Richter, M.; Sanchez-Guerrero, J.; Snaith, M.; Sturfelt, G.; Symmons, D.; Zoma, A. The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum., 1996, 39(3), 363-369.
[http://dx.doi.org/10.1002/art.1780390303] [PMID: 8607884]
[17]
Abhari, F.R. Ghanbari, Andarieh, M.; Ahmady, S. Estimating rate of insulin resistance in patients with preeclampsia using HOMA-IR index and comparison with nonpreeclampsia pregnant women. BioMed Res. Int., 2014, 2014, 1-6.
[http://dx.doi.org/10.1155/2014/140851]
[18]
Kato, A.; Ishida, J.; Endo, Y.; Takita, T.; Furuhashi, M.; Maruyama, Y.; Odamaki, M. Association of abdominal visceral adiposity and thigh sarcopenia with changes of arteriosclerosis in haemodialysis patients. Nephrol. Dial. Transplant., 2011, 26(6), 1967-1976.
[http://dx.doi.org/10.1093/ndt/gfq652] [PMID: 20980356]
[19]
Munakata, M. Brachial-ankle pulse wave velocity in the measurement of arterial stiffness: recent evidence and clinical applications. Curr. Hypertens. Rev., 2014, 10(1), 49-57.
[http://dx.doi.org/10.2174/157340211001141111160957] [PMID: 25392144]
[20]
Chin, C.W.; Tan, R.S.; Thumboo, J. Endothelial function and arterial stiffness assessment as early surrogate markers of vascular risk in patients with systemic lupus erythematosus. Clin. Exp. Rheumatol., 2013, 31(2), 295-301.
[PMID: 23110754]
[21]
Kwankaew, J.; Leelawattana, R.; Saignam, A.; Siripaitoon, B.; Uea-Areewongsa, P.; Juthong, S. Apolipoprotein B as an independent predictor of arterial stiffness in systemic lupus erythematosus patients. Int. J. Rheum. Dis., 2015, 18(4), 447-451.
[http://dx.doi.org/10.1111/1756-185X.12384] [PMID: 24797872]
[22]
Tso, T.K.; Huang, W.N.; Huang, H.Y.; Chang, C.K. Association of brachial-ankle pulse wave velocity with cardiovascular risk factors in systemic lupus erythematosus. Lupus, 2005, 14(11), 878-883.
[http://dx.doi.org/10.1191/0961203305lu2234oa] [PMID: 16335579]
[23]
Ding, F.M.; Li, M.; Yang, X.; Ye, Y.; Kang, L.; Pang, H.; Wang, Q.; Xu, D.; Zeng, X.; Zhang, S. Kang, L.; Pang, H.; Wang, Q.; Xu, D.; Zeng, X.; Zhang, S. Accelerated age-related arterial stiffness in systemic lupus erythematosus patients. J. Clin. Rheumatol., 2016, 22(8), 426-433.
[http://dx.doi.org/10.1097/RHU.0000000000000432] [PMID: 27870765]
[24]
Su-Angka, N.; Khositseth, A.; Vilaiyuk, S.; Tangnararatchakit, K.; Prangwatanagul, W. Carotid intima-media thickness and arterial stiffness in pediatric systemic lupus erythematosus. Lupus, 2017, 26(9), 989-995.
[http://dx.doi.org/10.1177/0961203317692434] [PMID: 28420050]
[25]
El Gamal, Y.M.; Elmasry, O.A.; El Hadidi, I.S.; Soliman, O.K. Proximal aortic stiffness is increased in systemic lupus erythematosus activity in children and adolescents. ISRN Pediatr., 2013, 2013765253
[http://dx.doi.org/10.1155/2013/765253] [PMID: 24171119]
[26]
Selzer, F.; Sutton-Tyrrell, K.; Fitzgerald, S.; Tracy, R.; Kuller, L.; Manzi, S. Vascular stiffness in women with systemic lupus erythematosus. Hypertension, 2001, 37(4), 1075-1082.
[http://dx.doi.org/10.1161/01.HYP.37.4.1075] [PMID: 11304506]
[27]
Sacre, K.; Escoubet, B.; Pasquet, B.; Chauveheid, M.P.; Zennaro, M.C.; Tubach, F.; Papo, T. Increased arterial stiffness in systemic lupus erythematosus (SLE) patients at low risk for cardiovascular disease: a cross-sectional controlled study. PLoS One, 2014, 9(4)e94511
[http://dx.doi.org/10.1371/journal.pone.0094511] [PMID: 24722263]
[28]
Ma, Y.; Zhou, L.; Dong, J. Arterial stiffness and increased kidney disease. Int. Urol. Nephrol., 2015, 47(7), 1157-1164.
[29]
Szabó, M.Z.; Szodoray, P.; Kiss, E. Dyslipidemia in systemic lupus erythematosus. Immunol. Res., 2017, 65(2), 543-550.
[http://dx.doi.org/10.1007/s12026-016-8892-9] [PMID: 28168401]
[30]
Urowitz, M.B.; Gladman, D.; Ibañez, D.; Fortin, P.; Sanchez-Guerrero, J.; Bae, S.; Clarke, A.; Bernatsky, S.; Gordon, C.; Hanly, J.; Wallace, D.; Isenberg, D.; Ginzler, E.; Merrill, J.; Alarcon, G.; Steinsson, K.; Petri, M.; Dooley, M.A.; Bruce, I.; Manzi, S.; Khamashta, M.; Ramsey-Goldman, R.; Zoma, A.; Sturfelt, G.; Nived, O.; Maddison, P.; Font, J.; van Vollenhoven, R.; Aranow, C.; Kalunian, K.; Stoll, T.; Buyon, J. Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort. Lupus, 2007, 16(9), 731-735.
[http://dx.doi.org/10.1177/0961203307081113] [PMID: 17728367]
[31]
Urowitz, M.B.; Gladmann, D.D.; Ibanez, D.; Fortin, P.; Sanchez-Guerrero, J.; Bae, S.; Clarke, A.; Bernatsky, S.; Gordon, C.; Hanly, J.; Wallace, D.; Isenberg, D.; Ginzler, E.; Merrill, J.; Alarcón, G.S.; Steinsson, K.; Petri, M.; Dooley, M.A.; Bruce, I.; Manzi, S.; Khamashta, M. Ramsey-Goldman, R. Zoma, A. Sturfelt, G.; Nived, O.; Maddison, P.; Font, J.; van Vollenhoven, R.; Aranow, C.; Kalunian, K; Stoll, T.; Systemic Lupus International Collaborating Clinics. Accumulation of coronary artery disease risk factors over three years: data from an inernational inception cohort. Arthritis Rheum., 2008, 59(2), 176-180.
[http://dx.doi.org/10.1002/art.23353] [PMID: 18240193]
[32]
Parra, S.; Lopez-Dupla, M.; Ibarretxe, D.; de Las Heras, M.; Amigó, N.; Català, A.; Benavent, M.; Garcés, E.; Navarro, A.; Castro, A. SLE patients show an increased arterial stiffness that is predicted by IgM-anti-ß2 -glycoprotein I and small dense HDL particles. Arthritis Care Res. (Hoboken), 2019, 71(1), 116-125.
[http://dx.doi.org/10.1002/acr.23594] [PMID: 29741228]
[33]
De, C.J.F.; Borba, E.F.; Viana, V.S.; Bueno, C.; Leon, E.P.; Bonfá, E. Antilipoprotein lipase antibodies: a new plyayer in the complex atherosclerotic process in systemic lupus erythematosus? Arthritis Rheum., 2004, 50(11), 3610-3615.
[http://dx.doi.org/10.1002/art.20630] [PMID: 15529371]
[34]
Yu, S.L.; Wong, C.K.; Szeto, C.C.; Li, E.K.; Cai, Z.; Tam, L.S. Members of the receptor for advanced glycation end products axis as potential therapeutic targets in patients with lupus nephritis. Lupus, 2015, 24(7), 675-686.
[http://dx.doi.org/10.1177/0961203314559631] [PMID: 25411258]
[35]
Tam, L.S.; Shang, Q.; Li, E.K.; Wong, S.; Li, R.J.; Lee, K.L.; Leung, Y.Y.; Ying, K.Y.; Yim, C.W.; Kun, E.W.; Leung, M.H.; Li, M.; Li, T.K.; Zhu, T.Y.; Chui, R.K.; Tseung, L.; Yu, S.L.; Kuan, W.P.; Yu, C.M. Serum soluble receptor for advanced glycation end products levels and aortic augmentation index in early rheumatoid arthritis--a prospective study. Semin. Arthritis Rheum., 2013, 42(4), 333-345.
[http://dx.doi.org/10.1016/j.semarthrit.2012.07.002] [PMID: 22920235]
[36]
Sabio, J.M.; Vargas-Hitos, J.A.; Martinez-Bordonado, J.; Navarrete-Navarrete, N.; Díaz-Chamorro, A.; Olvera-Porcel, C.; Zamora, M.; Jiménez-Alonso, J. Association between low 25-hydroxyvitamin D, insulin resistance and arterial stiffness in nondiabetic women with systemic lupus erythematosus. Lupus, 2015, 24(2), 155-163.
[http://dx.doi.org/10.1177/0961203314551811] [PMID: 25216653]

Rights & Permissions Print Cite
Article Metrics
11
1
© 2024 Bentham Science Publishers | Privacy Policy