Pharmacological and Therapeutic Aspects of Plants from the Genus Ferula: A Comprehensive Review

Author(s): Mohammad Sabzehzari, Mohammad Reza Naghavi, Motahare Bozari, Hossein M. Orafai, Thomas P. Johnston, Amirhossein Sahebkar*.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 20 , Issue 13 , 2020

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Abstract:

Inspired by nature, humankind has been able to attain significant achievements in the drug and food industries. Particularly, medicinal plants are a rich source of medicinal, cosmetic, sanitary, and aromatic substances. Genus Ferula from the Apiaceae family is a plant genus that possesses over 170 species, which have been carefully documented with regard to their medicinal properties. Ferula spp. affects many body organs, and their respective functions, in humans, such as the immune system, gastrointestinal tract, genitourinary, endocrine, respiratory, cardiovascular, nervous system, bone (skeleton), and teeth. In spite of the benefits, ferulosis (Ferula toxicity) is an important aspect of Ferula consumption in humans and animals. Hemorrhagic problems and infertility are important signs of ferulosis. In this review, we have described all of the effects of the active ingredients of Ferula spp. and their mechanisms of actions, when known, based on an extensive literature review. Thus, our review opens a window of the benefits of Ferula as a phyto-pharmaceutical and its therapeutic applications in pharmacy, dentistry, and medicine.

Keywords: Ferula, phytomedicine, pharmacy, dentistry, medicine, phyto-pharmaceutical.

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Article Details

VOLUME: 20
ISSUE: 13
Year: 2020
Page: [1233 - 1257]
Pages: 25
DOI: 10.2174/1389557520666200505125618
Price: $95

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