Login Register Cart 0
Generic placeholder image

Current Drug Discovery Technologies

Editor-in-Chief

ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Effect of Nectaroscordum koelzi Methanolic Extract on Acute and Chronic Inflammation in Male Mice

Author(s): Mojtaba Khaksarian, Hormoz Mahmoudvand, Maryam Alipour, Massumeh Naizi, Karam Hossein Hasanvand and Sedighe Nadri*

Volume 18, Issue 4, 2021

Published on: 01 May, 2020

Page: [525 - 531] Pages: 7

DOI: 10.2174/1568009620666200502012904

Price: $65

Abstract

Introduction: The present study deals with the effect of Nectaroscordum koelzi fruit extract on acute and chronic inflammation.

Methods: A total of 84 NMRI mice were used in this study. The effect of the extract on acute inflammation was analyzed by increasing vascular permeability via acetic acid and xylene induced ear edema among mice. The extract was evaluated in terms of effects on chronic inflammation by means of the cotton pellet test among mice. For the assessment of inflammation degree, the mice paw edema volume was measured by the plethysmometric test.

Results: The findings showed that the extract was effective on acute inflammation induced by acetic acid in mice. In the xylene ear edema, N. koelzi extract indicated a significant activity in mice. In the cotton pellet method, the methanol extract produced a significant reduction in comparison with the control and dexamethasone. Mice paw edema volume decreased with the extract.

Conclusion: In general, the data from the experiments indicated that the methanol extract of N. koelzi has an anti-inflammatory effect on acute and chronic inflammation. However, the exact contributing mechanisms have not been investigated for the pharmacological effects.

Keywords: Nectaroscordum koelzi, extract, anti-inflammation, formaldehyde, edema, immune deficiency.

Graphical Abstract

[1]
Khalili M, Naseri M. JAVAN BS Anti-inflammatory effect of alcoholic extract of datura stramonium seeds in male rats. J Qazvin Univ Med Sci Health Serv 2006; pp. 21-6.
[2]
Medzhitov R. Inflammation 2010: New adventures of an old flame. Cell 2010; 140(6): 771-6.
[http://dx.doi.org/10.1016/j.cell.2010.03.006] [PMID: 20303867]
[3]
El-Gabalawy H, Guenther LC, Bernstein CN. Epidemiology of immune-mediated inflammatory diseases: incidence, prevalence, natural history, and comorbidities. J Rheumatol Suppl 2010; 85: 2-10.
[http://dx.doi.org/10.3899/jrheum.091461] [PMID: 20436161]
[4]
Kuek A, Hazleman BL, Ostör AJ. Immune-mediated inflammatory diseases (IMIDs) and biologic therapy: a medical revolution. Postgrad Med J 2007; 83(978): 251-60.
[http://dx.doi.org/10.1136/pgmj.2006.052688] [PMID: 17403952]
[5]
Barcelos IP, Troxell RM, Graves JS. Mitochondrial Dysfunction and Multiple Sclerosis. Biology 2019; 11:8(2)
[http://dx.doi.org/10.3390/biology8020037]
[6]
Tsai DH, Riediker M, Berchet A, et al. Effects of short- and long-term exposures to particulate matter on inflammatory marker levels in the general population. Environ Sci Pollut Res Int 2019; 26(19): 19697-704.
[http://dx.doi.org/10.1007/s11356-019-05194-y] [PMID: 31079306]
[7]
Deepak P, Axelrad JE, Ananthakrishnan AN. The Role of the Radiologist in Determining Disease Severity in Inflammatory Bowel Diseases. Gastrointest Endosc Clin N Am 2019; 29(3): 447-70.
[http://dx.doi.org/10.1016/j.giec.2019.02.006] [PMID: 31078247]
[8]
Baghaei A, Emami MH, Adibi P, et al. Inflammatory bowel disease registry and monitoring: Feasibility study and application (Isfahan Inflammatory Bowel Disease Surveillance Project). Int J Prev Med 2019; 10: 190.
[http://dx.doi.org/10.4103/ijpvm.IJPVM_316_17] [PMID: 31807260]
[9]
Safarpour AR, Hosseini SV, Mehrabani D. Epidemiology of inflammatory bowel diseases in iran and Asia; a mini review. Iran J Med Sci 2013; 38(2)(Suppl.): 140-9.
[PMID: 24031103]
[10]
Machtaler S, Knieling F, Luong R, Tian L, Willmann JK. Assessment of Inflammation in an Acute on Chronic Model of Inflammatory Bowel Disease with Ultrasound Molecular Imaging. Theranostics 2015; 5(11): 1175-86.
[http://dx.doi.org/10.7150/thno.13048] [PMID: 26379784]
[11]
Reisdorf WC, Xie Q, Zeng X, et al. Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease. PLoS One 2019; 14(4)e0215033
[http://dx.doi.org/10.1371/journal.pone.0215033] [PMID: 31002701]
[12]
Rainsford KD. Anti-inflammatory drugs in the 21st century. Subcell Biochem 2007; 42: 3-27.
[http://dx.doi.org/10.1007/1-4020-5688-5_1] [PMID: 17612044]
[13]
Holvoet J, Terriere L, Van Hee W, Verbist L, Fierens E, Hautekeete ML. Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: a case-control study. Gut 1991; 32(7): 730-4.
[http://dx.doi.org/10.1136/gut.32.7.730] [PMID: 1855677]
[14]
Schellack N, Schellack G, Fourie J. A review of Non-Steroidal Anti-inflammatory Drugs. S Afr Pharm J 2015; 82(3): 8-18.
[15]
Mozaffarian V. Trees and Shrubs of Iran. 1st ed. Tehran, Iran: Farhang Moaser 2005.
[16]
Shafie-Zadeh F. Lorestan medicinal plants Lorestan University of Medical Sciences. Tehran: Hayyan press 2002; p. 32.
[17]
Ezatpour B, Azami M, Motamedi M, Rashidipour M, Mahmoudvand H, Alirezaei M, et al. Chemical composition, in vitro antibacterial and cytotoxicity effect of Nectaroscordum tripedale extract. Herb Med J 2016; 1(1): 29-36.
[18]
Khaksarian M, Hamidikia E, Sepahvand M, Farzan B. Antinociceptive Effects and Acute Toxicity of Nectaroscordum koelzi ex-tract in Mice. Entomol appl sci lett 2019; 6(3): 9-14.
[19]
Jahanbakhsh S, Azadpour M, Tavakoli Kareshk A, Keyhani A, Mahmoudvand H. Zataria multiflora Bioss: lethal effects of methanolic extract against protoscoleces of Echinococcus granulosus. J Parasit Dis 2016; 40(4): 1289-92.
[http://dx.doi.org/10.1007/s12639-015-0670-4] [PMID: 27876932]
[20]
Mahmoudvand H, Mirbadie SR, Ghasemi Kia M, Badparva E, Shamsadini Lori S, Fasihi Harandi M. Efficacy of Pistacia khinjuk Fruits on Viability of Hydatid Cyst Protoscoleces and Its Acute Toxicity in Mice Model. Iran J Parasitol 2016; 11(3): 383-8.
[PMID: 28127345]
[21]
Niazi M, Saki M, Sepahvand M, Jahanbakhsh S, Khatami M, Beyranvand M. In vitro and ex vivo scolicidal effects of Olea europaea L. to inactivate the protoscolecs during hydatid cyst surgery. Ann Med Surg (Lond) 2019; 42: 7-10.
[http://dx.doi.org/10.1016/j.amsu.2019.04.006] [PMID: 31193397]
[22]
Mahmoudvand H, Kheirandish F, Dezaki ES, Shamsaddini S, Harandi MF. Chemical composition, efficacy and safety of Pistacia vera (var. Fandoghi) to inactivate protoscoleces during hydatid cyst surgery. Biomed Pharmacother 2016; 82: 393-8.
[http://dx.doi.org/10.1016/j.biopha.2016.05.012] [PMID: 27470377]
[23]
Tavakoli Kareshk A, Keyhani A, Mahmoudvand H, et al. Efficacy of the Bunium persicum (Boiss) Essential Oil against Acute Toxoplasmosis in Mice Model. Iran J Parasitol 2015; 10(4): 625-31.
[PMID: 26811730]
[24]
Fereidoni M, Ahmadiani A, Semnanian S, Javan M. An accurate and simple method for measurement of paw edema. J Pharmacol Toxicol Methods 2000; 43(1): 11-4.
[http://dx.doi.org/10.1016/S1056-8719(00)00089-7] [PMID: 11091125]
[25]
Hosseinzadeh H, Ramezani M, Salmani G. Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats. J Ethnopharmacol 2000; 73(3): 379-85.
[http://dx.doi.org/10.1016/S0378-8741(00)00238-5] [PMID: 11090990]
[26]
Mahmoudvand H, Sheibani V, Shojaee S, et al. Toxoplasma gondii Infection Potentiates Cognitive Impairments of Alzheimer’s Disease in the BALB/c Mice. J Parasitol 2016; 102(6): 629-35.
[http://dx.doi.org/10.1645/16-28] [PMID: 27513205]
[27]
Mahmoudvand H, Ziaali N, Aghaei I, et al. The possible association between Toxoplasma gondii infection and risk of anxiety and cognitive disorders in BALB/c mice. Pathog Glob Health 2015; 109(8): 369-76.
[http://dx.doi.org/10.1080/20477724.2015.1117742] [PMID: 26924347]
[28]
Jage J. Opioid tolerance and dependence -- do they matter? Eur J Pain 2005; 9(2): 157-62.
[http://dx.doi.org/10.1016/j.ejpain.2004.11.009] [PMID: 15737807]
[29]
Hajhashemi V, Ghannadi A, Hajiloo M. Analgesic and anti-inflammatory effects of Rosa damascena hydroalcoholic extract and its essential oil in animal models. Iran J Pharm Res 2010; 9(2): 163-8.
[PMID: 24363723]
[30]
Hosseinzadeh H, Younesi HM. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol 2002; 2(1): 7.
[http://dx.doi.org/10.1186/1471-2210-2-7] [PMID: 11914135]
[31]
Hosseinzadeh H, Zarei H, Taghiabadi E. Antinociceptive, anti-inflammatory and acute toxicity effects of juglans regia L. Leaves in mice. Iran Red Crescent Med J 2011; 13(1): 27-33.
[PMID: 22946016]
[32]
Vogel HG, Vogel WH. Analgesic, anti-inflammatory, and antipyretic activity. 3nd ed... Drug Discovery and Evaluation: Springer 1997; pp. 360-420.
[http://dx.doi.org/10.1007/978-3-662-03333-3_8]
[33]
Zhao J, Maitituersun A, Li C, Li Q, Xu F, Liu T. Evaluation on Analgesic and Anti-Inflammatory Activities of Total Flavonoids from Juniperus sabina. Evid Based Complement Alternat Med 2018.20187965306
[http://dx.doi.org/10.1155/2018/7965306] [PMID: 30069226]
[34]
Olajide OA, Makinde JM, Awe SO. Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. J Ethnopharmacol 1999; 66(1): 113-7.
[http://dx.doi.org/10.1016/S0378-8741(99)00006-9] [PMID: 10432217]
[35]
Vinegar R, Truax JF, Selph JL. Quantitative studies of the pathway to acute carrageenan inflammation. Fed Proc 1976; 35(13): 2447-56.
[PMID: 976489]
[36]
Smucker E, Arhenius E, Hultin T. Alteration in microsomal electron transport, oxidative N-demethylation and azo-dye cleavage in CCl4 and dimethyl nitrosamine induced liver injury. Biochem J 1967; 103: 55-64.
[PMID: 6040018]
[37]
Fu KY, Light AR, Maixner W. Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw. J Pain 2001; 2(1): 2-11.
[http://dx.doi.org/10.1054/jpai.2001.9804] [PMID: 14622781]
[38]
Papich MG. Saunders Handbook of Veterinary Drugs Dexamethasone. St. Louis: W.B. Saunders 2016; pp. 217-9.
[39]
Olajide OA, Awe SO, Makinde JM, et al. Studies on the antiinflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark. J Ethnopharmacol 2000; 71(1-2): 179-86.
[http://dx.doi.org/10.1016/S0378-8741(99)00200-7] [PMID: 10904161]
[40]
SWINGLE KF. Evaluation for antiinflammatory activity.In: Anti-inflammatory agents. 3rd ed. New York: Academic Press 1974; pp. 33-122.

Rights & Permissions Print Cite
Article Metrics
11
1
© 2024 Bentham Science Publishers | Privacy Policy