Background: Thiazolidinoneones are important pharmaceutical compounds because of their biological activities. Several
methods for the synthesis of 4-thiazolidinones arewidely reported in the literature. The main
synthetic routes to synthesize 1,3-thiazolidin-4-ones involve three components reaction between amine, a carbonyl compound
and thioglycolic acid.
Objective: s-Proline covalented silicapropyl modified magnetic nanoparticles (Fe3O4@SiO2-Pr @s-proline) were prepared.
The antibacterial activity of synthesized nanoparticles againt four bacteras was investigated that showed that 30 Mg/L of
synthesized nanoparticles is the suitable concentration for bacterial inhibitory. Finally, the catalytic application of the
synthesized s-Proline covalented silicapropyl modified magnetic nanoparticles for the synthesis of thiazolidinones and
pyrazolyl thiazolidinones under stirring in aqeous media was evaluated. All of synthesized organic compounds were
characterized by mp, FT IR, 1H NMR, 13C NMR and elemental analysis.
Method: A combination of aldehyde (1.0 mmol), thioglycolic acid (1.0 mmol), various amines (1mmol) and 0.05 g
Fe3O4@SiO2propyl@L-proline, were reacted at room temperature under stirring in 10 mL water. After completion of the
reaction as indicated by TLC (4:1 hexane: ethylacetate), the reaction mixture was filtered in the presence of effective magnetic
bar to separate the nano catalyst. The nanocatalyst was washed with mixture of hot EtOH: H2O two times. The crude products
were collected and recrystallized from ethanol if necessary.
Results: we present a novel avenue for the synthesis of thiazolidinones in the presence of Fe3O4@SiO2-Pr @s-proline under
solvent free condition.
Conclusion: In conclusion, we have synthesized Fe3O4@SiO2-Pr@s-proline nanoparticles. Their biological activity against 4
bacterias was investigated. It released that 30Mg/L is the suitable concentration of synthesized nanoparticle for bacterial
inhibitory. The catalytic efficiency of catalyst was checked in multicomponent reaction of various aldehyde, thioglycolic acid
and various amines under stirring. This nano particle is a new organic-inorganic hybrid nanoparticle. The operational
simplicity, the excellent yields of products, ease of separation and recyclability of the magnetic catalyst, waste reduction and
high selectivity are the main advantages of this catalytic method. Furthermore, this new avenue is inexpensive and