p-Benzoquinone as a Privileged Scaffold of Pharmacological Significance: A Review

(E-pub Ahead of Print)

Author(s): Pragati Silakari, Priyanka Chhikara, Poonam Piplani*.

Journal Name: Mini-Reviews in Medicinal Chemistry

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Abstract:

Quinones are a huge class of compounds capable with affluent and captivating chemistry. p-Benzoquinone (pBNZ) or 1,4-Benzoquinone is a quinone compound which is the key structural motif of numerous biologically active molecules including synthetic and natural products that craft interest in its biological exploration to assess their prospective therapeutic implication. It acquires immense therapeutic potential with least side effects based on the different substitutions on this core molecule. This moiety has a marvelous capability to regulate a varied range of different cellular pathways that can be investigated for various selective activities. p-Benzoquinones have been a requisite core for the development of novel therapeutic molecules. In this standalone review, emphasis has been given on the various synthetic and pharmacological approaches along with structure activity relationship studies that emphasized on the chemical groups responsible for evoking the pharmacological potential of p-benzoquinone derivatives. The review is focused on the chemical, pharmaceutical and medicinal aspects of synthetic and natural benzoquinone derivatives that are seen in large classes of important compounds. The natural occurrences of p-benzoquinone derivatives with different pharmacological significance are also reported in this review.

Keywords: p-Benzoquinone, quinone, natural occurrences

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1389557520666200429101451
Price: $95