Andrographolide: Synthetic Methods and Biological Activities

(E-pub Ahead of Print)

Author(s): Meng Hao, Hui Xu*.

Journal Name: Mini-Reviews in Medicinal Chemistry

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Andrographolide, a labdane diterpenoid, is extracted and isolated from the plants of Andrographis paniculata. Andrographolide and its derivatives exhibited a wide range of biological properties including anticancer activity, antibacterial activity, hepatoprotective activity, anti-inflammatory activity, antiviral activity, anti-malarial activity, antidiabetic activity, insecticidal activity, etc. As a continuation, this review aims at giving an overview on the update advances (from 2015 to 2018) of andrographolide and it derivatives in regard to bioactivities, mechanisms of action, structural modifications, and structure-activity relationships.

Keywords: Andrographolide, biological activity, mechanism of action, structural modification, structure-activity relationship

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(E-pub Ahead of Print)
DOI: 10.2174/1389557520666200429100326
Price: $95

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