Discovery of New N-hydrazinecarbothioamide Indazole Hybrids: As Potential Radical (ABTS and DPPH) Scavengers

(E-pub Ahead of Print)

Author(s): Rafaila Rafique, Arshia, Kanwal, Khalid Mohammed Khan*, Sridevi Chigurupati, Uzma Salar, Muhammad Taha, Shahnaz Perveen.

Journal Name: Letters in Drug Design & Discovery

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Background: Free radicals are the main cause of numerous diseases. Their overproduction needs to be controlled in order to combat several ailments. Current study deals with the discovery of new free radical scavengers.

Methods: Substituted N-hydrazinecarbothioamide indazoles 1-18 were evaluated for DPPH and ABTS radical scavenging activities.

Results: All synthetic compounds possess good radical DPPH and ABTS scavenging potential in the ranges of IC50 = 2.11 ± 0.17 - 5.3 ± 0.11 µM and IC50 = 2.31 ± 0.06 - 5.5 ± 0.07 µM, respectively, as compared to standard ascorbic acid having IC50 = 2.02 ± 0.11 µM for DPPH and IC50 = 2.1 ± 0.07 µM for ABTS.

Conclusion: These compounds could serve as leads for antioxidant activity those have the ability to control free radical generation and ward off free radical-induced disorders.

Keywords: Indazole, carbothioamide, antioxidant, radical scavengers, DPPH, ABTS.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1570180817999200424074455
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