Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect

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Author(s): Sudip Kumar Mandal, Utsab Debnath, Amresh Kumar, Sabu Thomas, Subhash Chandra Mandal, Manabendra Dutta Choudhury, Partha Palit*

Journal Name: Letters in Drug Design & Discovery

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Background and Introduction: Sesquiterpene lactones are a class of secondary metabolite that consist of sesquiterpenoids and lactone ring as pharmacophore moiety. Large group of bio-active secondary metabolites as phytopharmaceuticals belong to this category. Asteraceae family based medicinal plants, from which more than 5,000 sesquiterpene lactones have been reported so far. Sesquiterpene lactone-based pharmacophore moieties hold promise for broadspectrum biological activities against cancer, inflammation, parasitic, bacterial, fungal, viral infection and other functional disorders. Moreover, this moiety based phytocompounds have been spotlighted with new dimension in the natural drug discovery program worldwide after 2015 Medicine Nobel Prize achieved by the Artemisinin researchers.

Objective: These bitter substances often contain an α, β-unsaturated-γ-lactone as a major structural backbone, which in recent studies has been explored to be associated with antitumor, cytotoxic, anti-inflammatory action. Recently, outlook of sesquiterpene lactones as phytomedicine has been increased. This study will be reviewed the future prospect of sesquiterpene lactones against inflammation and cancer.

Methods: Hence, we have emphasized the different features of this moiety by incorporating its structural diversity on biological activities to explore structure activity relationships (SAR) against inflammation and cancer.

Results: How dual mode of action as anti-inflammatory and anti-cancer have been envisioned by this phytopharmaceuticals will be forecasted in this study. Furthermore, the corelation of anti-inflammatory and anti-cancer activity executed by the sesquiterpene lactones for fruitful phytotherapy will be revealed in the present review in the milieu of pharmacophore activity relation and pharmacodynamics study as well.

Conclusion: So, these metabolites are paramount in phytopharmacological aspects. The present discussion on future prospect of this moiety based on the reported literature could be the useful guide for anti-inflammatory and anti-cancer drug discovery program for the upcoming researchers.

Keywords: Sesquiterpene lactone, Michael acceptor, anti-inflammatory, anticancer, in-silico, QSAR, docking.

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(E-pub Ahead of Print)
DOI: 10.2174/1570180817999200421144007
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