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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Plant Extracts and Isolated Compounds Reduce Parameters of Oxidative Stress Induced by Heavy Metals: An up-to-Date Review on Animal Studies

Author(s): Ivana Mirkov, Dejan Stojković, Aleksandra P. Aleksandrov, Marija Ivanov, Marina Kostić, Jasmina Glamočlija and Marina Soković*

Volume 26, Issue 16, 2020

Page: [1799 - 1815] Pages: 17

DOI: 10.2174/1381612826666200407163408

Price: $65

Abstract

Background: Heavy metals are elements that are naturally found in the earth. They are used in many modern-day applications in agriculture, medicine, and industry. Heavy metal poisoning occurs when the body’s soft tissues absorb too much of a particular metal. The heavy metals of interest for this review paper were cadmium, arsenic, mercury, and lead since these are the most common metals that the human body can absorb in toxic amounts. Different plant species were investigated in recent years for their effect on oxidative stress parameters after intoxication with heavy metals.

Objectives: This review paper is focused on the current update to research on heavy metals induced oxidative stress in animal models and improvement of the oxidative stress parameters upon/co-/after treatment with different plant extracts and isolated compounds.

Methods: The available literature was screened for the novel data regarding the influence of plant extracts and compounds on heavy metals induced oxidative stress. For that purposes Scopus database was used, looking for the publications in the last 5-10 years with the key terms: plant extracts, oxidative stress, in vivo, cadmium, lead, mercury and arcenic.

Results: Various parameters of oxidative stress were investigated, and their improvement with plant extracts/ compounds was observed in the brain, lungs, kidneys, liver, uterus, testis, thymus, spleen, heart, skin and blood of experimental animals. Common parameters used to determine oxidative stress in animals were: superoxide dismutase; catalase; reduced glutathione; glutathione reductase; glutathione-S-transferase; glutathione peroxidase; lipid peroxidation; oxidized glutathione; malondialdehyde; xanthine oxidase; nonprotein-soluble thiol; thioredoxin reductase; total sulphydryl group; nitric oxide; γ-glutamyl cysteine synthetase.

Conclusion: The most investigated species for antioxidant effects upon intoxication with heavy metals seem to be Allium sp., Bacopa monniera, Camellia sinensis, Moringa oleifera, Vitis vinifera and Zingiber officinale. According to literature data, the most promising effect to alleviate symptoms of intoxication was achieved with proanthocyanidins obtained from Vitis vinifera.

Keywords: Cadmium, arsenic, mercury, lead, oxidative stress, plant extracts.

« Previous Next »
[1]
Järup L. Hazards of heavy metal contamination. Br Med Bull 2003; 68: 167-82.
[http://dx.doi.org/10.1093/bmb/ldg032] [PMID: 14757716]
[2]
Sharma B, Singh S, Siddiqi NJ. Biomedical implications of heavy metals induced imbalances in redox systems. BioMed Res Int 2014; 2014 640754
[http://dx.doi.org/10.1155/2014/640754] [PMID: 25184144]
[3]
Ercal N, Gurer-Orhan H, Aykin-Burns N. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 2001; 1(6): 529-39.
[http://dx.doi.org/10.2174/1568026013394831] [PMID: 11895129]
[4]
Wu X, Cobbina SJ, Mao G, Xu H, Zhang Z, Yang L. A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment. Environ Sci Pollut Res Int 2016; 23(9): 8244-59.
[http://dx.doi.org/10.1007/s11356-016-6333-x] [PMID: 26965280]
[5]
Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J 2012; 5(1): 9-19.
[http://dx.doi.org/10.1097/WOX.0b013e3182439613] [PMID: 23268465]
[6]
Ma Q. Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 2013; 53: 401-26.
[http://dx.doi.org/10.1146/annurev-pharmtox-011112-140320] [PMID: 23294312]
[7]
Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 2004; 142(2): 231-55.
[http://dx.doi.org/10.1038/sj.bjp.0705776] [PMID: 15155533]
[8]
WHO. In: (World Health Organization), Regional Office for Europe, Second Evaluation of the Strategy for Health for All by the year 2000. Copenhagen, Denmark: World Health Organization 1991.
[9]
Waalkes MP. Cadmium carcinogenesis. Mutat Res 2003; 533(1-2): 107-20.
[http://dx.doi.org/10.1016/j.mrfmmm.2003.07.011] [PMID: 14643415]
[10]
Ohta H, Yamauchi Y, Nakakita M, et al. Relationship between renal dysfunction and bone metabolism disorder in male rats after long-term oral quantitative cadmium administration. Ind Health 2000; 38(4): 339-55.
[http://dx.doi.org/10.2486/indhealth.38.339] [PMID: 11061477]
[11]
Chandler JD, Wongtrakool C, Banton SA, et al. Low-dose oral cadmium increases airway reactivity and lung neuronal gene expression in mice. Physiol Rep 2016; 4(13) e12821
[http://dx.doi.org/10.14814/phy2.12821] [PMID: 27401458]
[12]
Buck Louis GM, Sundaram R, Schisterman EF, et al. Heavy metals and couple fecundity, the LIFE Study. Chemosphere 2012; 87(11): 1201-7.
[http://dx.doi.org/10.1016/j.chemosphere.2012.01.017] [PMID: 22309709]
[13]
Satarug S, Garrett SH, Sens MA, Sens DA. Cadmium, environmental exposure, and health outcomes. Environ Health Perspect 2010; 118(2): 182-90.
[http://dx.doi.org/10.1289/ehp.0901234] [PMID: 20123617]
[14]
Rani A, Kumar A, Lal A, Pant M. Cellular mechanisms of cadmium-induced toxicity: a review. Int J Environ Health Res 2014; 24(4): 378-99.
[http://dx.doi.org/10.1080/09603123.2013.835032] [PMID: 24117228]
[15]
Havsteen BH. The biochemistry and medical significance of the flavonoids. Pharmacol Ther 2002; 96(2-3): 67-202.
[http://dx.doi.org/10.1016/S0163-7258(02)00298-X] [PMID: 12453566]
[16]
Nazima B, Manoharan V, Miltonprabu S. Oxidative stress induced by cadmium in the plasma, erythrocytes and lymphocytes of rats: Attenuation by grape seed proanthocyanidins. Hum Exp Toxicol 2016; 35(4): 428-47.
[http://dx.doi.org/10.1177/0960327115591376] [PMID: 26089033]
[17]
Manoharan V, Prabu SM. Protective role of grape seed proanthocyanidins against cadmium induced hepatic dysfunction in rats. Toxicol Res (Camb) 2014; 3(2): 131-41.
[http://dx.doi.org/10.1039/c3tx50085c]
[18]
Bashir N, Manoharan V, Miltonprabu S. Grape seed proanthocyanidins protects against cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling. J Nutr Biochem 2016; 32: 128-41.
[http://dx.doi.org/10.1016/j.jnutbio.2016.03.001] [PMID: 27142746]
[19]
Lei Y, Chen Q, Chen J, Liu D. Potential ameliorative effects of grape seed-derived polyphenols against cadmium induced prostatic deficits. Biomed Pharmacother 2017; 91: 707-13.
[http://dx.doi.org/10.1016/j.biopha.2017.05.006] [PMID: 28499242]
[20]
El-Tarras Ael-S, Attia HF, Soliman MM, El Awady MA, Amin AA. Neuroprotective effect of grape seed extract against cadmium toxicity in male albino rats. Int J Immunopathol Pharmacol 2016; 29(3): 398-407.
[http://dx.doi.org/10.1177/0394632016651447] [PMID: 27271977]
[21]
Boiago Gollucke AP, Claudio SR, Yamamura H, et al. Grape skin extract mitigates tissue degeneration, genotoxicity, and oxidative status in multiple organs of rats exposed to cadmium. Eur J Cancer Prev 2018; 27(1): 70-81.
[http://dx.doi.org/10.1097/CEJ.0000000000000273] [PMID: 27472085]
[22]
Abo-EL-Sooud K Ahmed FA, El-Toumy SA, Yaecob HS, & ELTantawy HM. Phytochemical, anti-inflammatory, anti-ulcerogenic and hypoglycemic activities of Periploca angustifolia L extracts in rats. Clin Phytoscience 2018; 4(1): 27.
[http://dx.doi.org/10.1186/s40816-018-0087-6]
[23]
Athmouni K, Belhaj D, Mkadmini Hammi K, El Feki A, Ayadi H. Phenolic compounds analysis, antioxidant, and hepatoprotective effects of Periploca angustifolia extract on cadmium-induced oxidative damage in HepG2 cell line and rats. Arch Physiol Biochem 2018; 124(3): 261-74.
[http://dx.doi.org/10.1080/13813455.2017.1395890] [PMID: 29156993]
[24]
Athmouni K, Belhaj D, El Feki A, Ayadi H. Optimization, antioxidant properties and GC-MS analysis of Periploca angustifolia polysaccharides and chelation therapy on cadmium-induced toxicity in human HepG2 cells line and rat liver. Int J Biol Macromol 2018; 108: 853-62.
[http://dx.doi.org/10.1016/j.ijbiomac.2017.10.175] [PMID: 29101047]
[25]
Athmouni K, Belhaj D, Chawech R, Jarraya R, El Feki A, Ayadi H. Characterization of polysaccharides isolated from Periploca angustifolia and its antioxidant activity and renoprotective potential against cadmium induced toxicity in HEK293 cells and rat kidney. Int J Biol Macromol 2019; 125: 730-42.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.12.046] [PMID: 30521922]
[26]
Yu Y, Shen M, Song Q, Xie J. Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review. Carbohydr Polym 2018; 183: 91-101.
[http://dx.doi.org/10.1016/j.carbpol.2017.12.009] [PMID: 29352896]
[27]
Zhang L, Li Q, Zheng G, et al. Protective effect of Lycium barbarum polysaccharides against cadmium-induced testicular toxicity in male mice. Food Funct 2017; 8(6): 2322-30.
[http://dx.doi.org/10.1039/C6FO01583B] [PMID: 28594424]
[28]
Shen R, Liu D, Hou C, et al. Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo. Food Funct 2017; 8(10): 3636-46.
[http://dx.doi.org/10.1039/C7FO00495H] [PMID: 28905953]
[29]
Giampieri F, Alvarez-Suarez JM, Battino M. Strawberry and human health: effects beyond antioxidant activity. J Agric Food Chem 2014; 62(18): 3867-76.
[http://dx.doi.org/10.1021/jf405455n] [PMID: 24450925]
[30]
Skrovankova S, Sumczynski D, Mlcek J, Jurikova T, Sochor J. Bioactive compounds and antioxidant activity in different types of berries. Int J Mol Sci 2015; 16(10): 24673-706.
[http://dx.doi.org/10.3390/ijms161024673] [PMID: 26501271]
[31]
Elkhadragy MF, Kassab RB, Metwally D, et al. Protective effects of Fragaria ananassa methanolic extract in a rat model of cadmium chloride-induced neurotoxicity. Biosci Rep 2018; 38(6) BSR20180861
[http://dx.doi.org/10.1042/BSR20180861] [PMID: 30291211]
[32]
Elmallah MIY, Elkhadragy MF, Al-Olayan EM, Abdel Moneim AE. Protective effect of Fragaria ananassa crude extract on cadmium-induced lipid peroxidation, antioxidant enzymes suppression, and apoptosis in rat testes. Int J Mol Sci 2017; 18(5): 957.
[http://dx.doi.org/10.3390/ijms18050957] [PMID: 28475120]
[33]
Elkhadragy MF, Abdel Moneim AE. Protective effect of Fragaria ananassa methanolic extract on cadmium chloride (CdCl2)-induced hepatotoxicity in rats. Toxicol Mech Methods 2017; 27(5): 335-45.
[http://dx.doi.org/10.1080/15376516.2017.1285973] [PMID: 28110594]
[34]
Oszmiański J. Wojdylo. Aronia melanocarpa phenolics and their antioxidant activity. Eur Food Res Technol 2005; 221(6): 809-13.
[http://dx.doi.org/10.1007/s00217-005-0002-5]
[35]
Brzóska MM, Rogalska J, Roszczenko A, Galazyn-Sidorczuk M, Tomczyk M. The mechanism of the osteoprotective action of a polyphenol-rich Aronia melanocarpa extract during chronic exposure to cadmium is mediated by the oxidative defense system. Planta Med 2016; 82(7): 621-31.
[http://dx.doi.org/10.1055/s-0042-103593] [PMID: 27096624]
[36]
Mężyńska M, Brzóska MM, Rogalska J, Galicka A. Extract from Aronia melanocarpa L. berries protects against cadmium-induced lipid peroxidation and oxidative damage to proteins and dna in the liver: a study using a rat model of environmental human exposure to this xenobiotic. Nutrients 2019; 11(4): 758.
[http://dx.doi.org/10.3390/nu11040758] [PMID: 30935147]
[37]
Mężyńska M, Brzóska MM, Rogalska J, Piłat-Marcinkiewicz B. Extract from Aronia melanocarpa L. berries prevents cadmium-induced oxidative stress in the liver: A study in a rat model of low-level and moderate lifetime human exposure to this toxic metal. Nutrients 2018; 11(1): 21.
[http://dx.doi.org/10.3390/nu11010021] [PMID: 30577648]
[38]
Doğru YZ, Erat M. Investigation of some kinetic properties of polyphenol oxidase from parsley (Petroselinum crispum, Apiaceae). Food Res Int 2012; 49(1): 411-5.
[http://dx.doi.org/10.1016/j.foodres.2012.07.028]
[39]
Maodaa SN, Allam AA, Ajarem J, Abdel-Maksoud MA, Al-Basher GI, Wang ZY. Effect of parsley (Petroselinum crispum, Apiaceae) juice against cadmium neurotoxicity in albino mice (Mus musculus). Behav Brain Funct 2016; 12(1): 6.
[http://dx.doi.org/10.1186/s12993-016-0090-3] [PMID: 26846273]
[40]
Allam AA, Maodaa SN, Abo-Eleneen R, Ajarem J. Protective effect of parsley juice (Petroselinum crispum, Apiaceae) against cadmium deleterious changes in the developed albino mice newborns (Mus musculus) brain. Oxid Med Cell Longev 2016; 2016 2646840
[http://dx.doi.org/10.1155/2016/2646840] [PMID: 26966507]
[41]
Saha S, Ghosh S. Tinospora cordifolia: One plant, many roles. Anc Sci Life 2012; 31(4): 151-9.
[http://dx.doi.org/10.4103/0257-7941.107344] [PMID: 23661861]
[42]
Padma VV, Baskaran R, Divya S, Priya LB, Saranya S. Modulatory effect of Tinospora cordifolia extract on Cd-induced oxidative stress in Wistar rats. Integr Med Res 2016; 5(1): 48-55.
[http://dx.doi.org/10.1016/j.imr.2015.12.005] [PMID: 28462097]
[43]
Baskaran R, Priya LB, Sathish Kumar V, Padma VV. Tinospora cordifolia extract prevents cadmium-induced oxidative stress and hepatotoxicity in experimental rats. J Ayurveda Integr Med 2018; 9(4): 252-7.
[http://dx.doi.org/10.1016/j.jaim.2017.07.005] [PMID: 30316725]
[44]
Priya LB, Baskaran R, Elangovan P, Dhivya V, Huang CY, Padma VV. Tinospora cordifolia extract attenuates cadmium-induced biochemical and histological alterations in the heart of male Wistar rats. Biomed Pharmacother 2017; 87: 280-7.
[http://dx.doi.org/10.1016/j.biopha.2016.12.098] [PMID: 28063409]
[45]
Abdelrazek HM, Helmy SA, Elsayed DH, Ebaid HM, Mohamed RM. Ameliorating effects of green tea extract on cadmium induced reproductive injury in male Wistar rats with respect to androgen receptors and caspase- 3. Reprod Biol 2016; 16(4): 300-8.
[http://dx.doi.org/10.1016/j.repbio.2016.11.001] [PMID: 27840064]
[46]
Winiarska-Mieczan A. The potential protective effect of green, black, red and white tea infusions against adverse effect of cadmium and lead during chronic exposure - A rat model study. Regul Toxicol Pharmacol 2015; 73(2): 521-9.
[http://dx.doi.org/10.1016/j.yrtph.2015.10.007] [PMID: 26472100]
[47]
Onyenibe NS, Fowokemi KT, Emmanuel OB. African Nutmeg (Monodora myristica) lowers cholesterol and modulates lipid peroxidation in experimentally induced hypercholesterolemic male Wistar rats. Int J Biomed Sci 2015; 11(2): 86-92.
[PMID: 26199582]
[48]
Oyinloye BE, Ajiboye BO, Ojo OA, Musa HM, Onikanni SA. Ojo AA. Ameliorative potential of Aframomum melegueta extract in cadmium-induced hepatic damage and oxidative stress in male Wistar rats. J App Pharmaceutical Sci 2016; 7(6): 094-9.
[49]
Oyinloye BE, Adenowo AF, Osunsanmi FO, Ogunyinka BI, Nwozo SO, Kappo AP. Aqueous extract of Monodora myristica ameliorates cadmium-induced hepatotoxicity in male rats. Springerplus 2016; 5(1): 641.
[http://dx.doi.org/10.1186/s40064-016-2228-z] [PMID: 27330907]
[50]
Nwozo SO, Oyinloye BE. Hepatoprotective effect of aqueous extract of Aframomum melegueta on ethanol-induced toxicity in rats. Acta Biochim Pol 2011; 58(3): 355-8.
[http://dx.doi.org/10.18388/abp.2011_2246] [PMID: 21887409]
[51]
Al Omairi NE, Radwan OK, Alzahrani YA, Kassab RB. Neuroprotective efficiency of Mangifera indica leaves extract on cadmium-induced cortical damage in rats. Metab Brain Dis 2018; 33(4): 1121-30.
[http://dx.doi.org/10.1007/s11011-018-0222-6] [PMID: 29557530]
[52]
Ghosh J, Das J, Manna P, Sil PC. Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway. Food Chem 2010; 123(4): 1062-75.
[http://dx.doi.org/10.1016/j.foodchem.2010.05.062]
[53]
Bhattacharjee B, Pal PK, Ghosh AK, Mishra S, Chattopadhyay A, Bandyopadhyay D. Aqueous bark extract of Terminalia arjuna protects against cadmium-induced hepatic and cardiac injuries in male Wistar rats through antioxidative mechanisms. Food Chem Toxicol 2019; 124: 249-64.
[http://dx.doi.org/10.1016/j.fct.2018.12.008] [PMID: 30529122]
[54]
Lutz M, Henríquez C, Escobar M. Chemical composition and antioxidant properties of mature and baby artichokes (Cynara scolymus L.), raw and cooked. J Food Compos Anal 2011; 24(1): 49-54.
[http://dx.doi.org/10.1016/j.jfca.2010.06.001]
[55]
El-Boshy M, Ashshi A, Gaith M, et al. Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats. Environ Sci Pollut Res Int 2017; 24(13): 12372-83.
[http://dx.doi.org/10.1007/s11356-017-8876-x] [PMID: 28357802]
[56]
Dastan D, Karimi S, Larki-Harchegani A, Nili-Ahmadabadi A. Protective effects of Allium hirtifolium Boiss extract on cadmium-induced renal failure in rats. Environ Sci Pollut Res Int 2019; 26(18): 18886-92.
[http://dx.doi.org/10.1007/s11356-019-04656-7] [PMID: 31077048]
[57]
Du L, Lei Y, Chen J, Song H, Wu X. Potential ameliorative effects of Qing Ye Dan against cadmium induced prostatic deficits via regulating Nrf-2/HO-1 and TGF-β1/Smad pathways. Cell Physiol Biochem 2017; 43(4): 1359-68.
[http://dx.doi.org/10.1159/000481847] [PMID: 28992620]
[58]
Adaramoye OA, Akanni OO. Protective effects of Artocarpus altilis (Moraceae) on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats. Andrologia 2016; 48(2): 152-63.
[http://dx.doi.org/10.1111/and.12426] [PMID: 25912632]
[59]
Ramamurthy CH, Subastri A, Suyavaran A, Subbaiah KCV, Valluru L, Thirunavukkarasu C. Solanum torvum Swartz. fruit attenuates cadmium-induced liver and kidney damage through modulation of oxidative stress and glycosylation. Environ Sci Pollut Res Int 2016; 23(8): 7919-29.
[http://dx.doi.org/10.1007/s11356-016-6044-3] [PMID: 26762936]
[60]
Imafidon CE, Olukiran OS, Ogundipe DJ, Eluwole AO, Adekunle IA, Oke GO. Acetonic extract of Vernonia amygdalina (Del.) attenuates Cd-induced liver injury: Potential application in adjuvant heavy metal therapy. Toxicol Rep 2018; 5: 324-32.
[http://dx.doi.org/10.1016/j.toxrep.2018.02.009] [PMID: 29854601]
[61]
Claudio SR, Gollucke AP, Yamamura H, et al. Purple carrot extract protects against cadmium intoxication in multiple organs of rats: Genotoxicity, oxidative stress and tissue morphology analyses. J Trace Elem Med Biol 2016; 33: 37-47.
[http://dx.doi.org/10.1016/j.jtemb.2015.08.006] [PMID: 26653742]
[62]
Flora SJS. Arsenic-induced oxidative stress and its reversibility. Free Radic Biol Med 2011; 51(2): 257-81.
[http://dx.doi.org/10.1016/j.freeradbiomed.2011.04.008] [PMID: 21554949]
[63]
National Research Council Board on Environmental Studies and Toxicology. In: Arsenic in drinking water, Committee on Toxicology, Sub-committee on Arsenic in Drinking Water. Washington, DC: Natl Acad Press 1999.
[64]
Morales KH, Ryan L, Kuo TL, Wu MM, Chen CJ. Risk of internal cancers from arsenic in drinking water. Environ Health Perspect 2000; 108(7): 655-61.
[http://dx.doi.org/10.1289/ehp.00108655] [PMID: 10903620]
[65]
Celik I, Gallicchio L, Boyd K, et al. Arsenic in drinking water and lung cancer: a systematic review. Environ Res 2008; 108(1): 48-55.
[http://dx.doi.org/10.1016/j.envres.2008.04.001] [PMID: 18511031]
[66]
Alonso FT, Garmendia ML, Bogado ME. Increased skin cancer mortality in Chile beyond the effect of ageing: Temporal analysis 1990 to 2005. Acta Derm Venereol 2010; 90(2): 141-6.
[http://dx.doi.org/10.2340/00015555-0787] [PMID: 20169296]
[67]
Meliker JR, Slotnick MJ, AvRuskin GA, et al. Lifetime exposure to arsenic in drinking water and bladder cancer: a population-based case-control study in Michigan, USA. Cancer Causes Control 2010; 21(5): 745-57.
[http://dx.doi.org/10.1007/s10552-010-9503-z] [PMID: 20084543]
[68]
Chen CL, Chiou HY, Hsu LI, et al. Arsenic in drinking water and risk of urinary tract cancer: a follow-up study from northeastern Taiwan. Cancer Epidemiol Biomarkers Prev 2010; 19(1): 101-10.
[http://dx.doi.org/10.1158/1055-9965.EPI-09-0333] [PMID: 20056628]
[69]
Perveen H, Dash M, Khatun S, Maity M, Islam SS, Chattopadhyay S. Electrozymographic evaluation of the attenuation of arsenic induced degradation of hepatic SOD, catalase in an in vitro assay system by pectic polysaccharides of Momordica charantia in combination with curcumin. Biochem Biophys Rep 2017; 11: 64-71.
[http://dx.doi.org/10.1016/j.bbrep.2017.06.002] [PMID: 28955769]
[70]
Dua TK, Dewanjee S, Gangopadhyay M, Khanra R, Zia-Ul-Haq M, De Feo V. Ameliorative effect of water spinach, Ipomea aquatica (Convolvulaceae), against experimentally induced arsenic toxicity. J Transl Med 2015; 13: 81.
[http://dx.doi.org/10.1186/s12967-015-0430-3] [PMID: 25890105]
[71]
Dua TK, Dewanjee S, Khanra R. Prophylactic role of Enhydra fluctuans against arsenic-induced hepatotoxicity via anti-apoptotic and antioxidant mechanisms. Redox Rep 2016; 21(4): 147-54.
[PMID: 26066906]
[72]
Xu M, Niu Q, Hu Y, Feng G, Wang H, Li S. Proanthocyanidins antagonize arsenic-induced oxidative damage and promote arsenic methylation through activation of the Nrf2 signaling pathway. Oxid Med Cell Longev 2019; 2019 8549035
[http://dx.doi.org/10.1155/2019/8549035] [PMID: 30805085]
[73]
Vineetha VP, Girija S, Soumya RS, Raghu KG. Polyphenol-rich apple (Malus domestica L.) peel extract attenuates arsenic trioxide induced cardiotoxicity in H9c2 cells via its antioxidant activity. Food Funct 2014; 5(3): 502-11.
[http://dx.doi.org/10.1039/c3fo60470e] [PMID: 24441683]
[74]
Wei M, Guo F, Rui D, et al. Alleviation of arsenic-induced pulmonary oxidative damage by GSPE as shown during in vivo and in vitro experiments. Biol Trace Elem Res 2018; 183(1): 80-91.
[http://dx.doi.org/10.1007/s12011-017-1111-2] [PMID: 28803342]
[75]
Dwivedi S, Kumar M, Trivedi SP. Mitigating potential of Melissa officinale against As3+-induced cytotoxicity and transcriptional alterations of Hsp70 and Hsp27 in fish, Channa punctatus (Bloch). Environ Monit Assess 2017; 189(7): 306.
[http://dx.doi.org/10.1007/s10661-017-6002-7] [PMID: 28573351]
[76]
Sinha D, Roy S, Roy M. Antioxidant potential of tea reduces arsenite induced oxidative stress in Swiss albino mice. Food Chem Toxicol 2010; 48(4): 1032-9.
[http://dx.doi.org/10.1016/j.fct.2010.01.016] [PMID: 20096321]
[77]
Messarah M, Saoudi M, Boumendjel A, Kadeche L, Boulakoud MS, El Feki A. Green tea extract alleviates arsenic-induced biochemical toxicity and lipid peroxidation in rats. Toxicol Ind Health 2013; 29(4): 349-59.
[http://dx.doi.org/10.1177/0748233711433934] [PMID: 22301814]
[78]
Acharyya N, Chattopadhyay S, Maiti S. Chemoprevention against arsenic-induced mutagenic DNA breakage and apoptotic liver damage in rat via antioxidant and SOD1 upregulation by green tea (Camellia sinensis) which recovers broken DNA resulted from arsenic-H2O2 related in vitro oxidant stress. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2014; 32(4): 338-61.
[http://dx.doi.org/10.1080/10590501.2014.967061] [PMID: 25436473]
[79]
Acharyya N, Sajed Ali S, Deb B, Chattopadhyay S, Maiti S. Green tea (Camellia sinensis) alleviates arsenic-induced damages to DNA and intestinal tissues in rat and in situ intestinal loop by reinforcing antioxidant system. Environ Toxicol 2015; 30(9): 1033-44.
[http://dx.doi.org/10.1002/tox.21977] [PMID: 24615952]
[80]
Chandronitha C, Ananthi S, Ramakrishnan G, Lakshmisundaram R, Gayathri V, Vasanthi HR. Protective role of tannin-rich fraction of Camellia sinensis in tissue arsenic burden in Sprague Dawley rats. Hum Exp Toxicol 2010; 29(9): 705-19.
[http://dx.doi.org/10.1177/0960327110361503] [PMID: 20144955]
[81]
Nam S, Smith DM, Dou QP. Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and Bax expression, and induces G1 arrest and apoptosis. Cancer Epidemiol Biomarkers Prev 2001; 10(10): 1083-8.
[PMID: 11588135]
[82]
Day A, Chattopadhyay S, Jana S, et al. Restoration of uterine redox-balance by methanolic extract of Camellia sinensis in arsenicated rats. Acta Biol Szeged 2018; 62(1): 7-15.
[http://dx.doi.org/10.14232/abs.2018.1.7-15]
[83]
Pan X, Dai Y, Li X, et al. Inhibition of arsenic-induced rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-β/Smad activation. Toxicol Appl Pharmacol 2011; 254(3): 323-31.
[http://dx.doi.org/10.1016/j.taap.2011.04.022] [PMID: 21605584]
[84]
Zhang J, Pan X, Li N, et al. Grape seed extract attenuates arsenic-induced nephrotoxicity in rats. Exp Ther Med 2014; 7(1): 260-6.
[http://dx.doi.org/10.3892/etm.2013.1381] [PMID: 24348802]
[85]
Li SG, Ding YS, Niu Q, et al. Grape seed proanthocyanidin extract alleviates arsenic-induced oxidative reproductive toxicity in male mice. Biomed Environ Sci 2015; 28(4): 272-80.
[PMID: 25966753]
[86]
Sharma A, Sharma MK, Kumar M. Modulatory role of Emblica officinalis fruit extract against arsenic induced oxidative stress in Swiss albino mice. Chem Biol Interact 2009; 180(1): 20-30.
[http://dx.doi.org/10.1016/j.cbi.2009.01.012] [PMID: 19428342]
[87]
Maiti S, Chattopadhyay S, Acharyya N, Deb B, Kumar Hati A. Emblica officinalis (amla) ameliorates arsenic-induced liver damage via DNA protection by antioxidant systems. Mol Cell Toxicol 2014; 10: 75-82.
[http://dx.doi.org/10.1007/s13273-014-0009-8]
[88]
Singh MK, Dwivedi S, Yadav SS, Sharma P, Khattri S. Arsenic-induced hepatic toxicity and its attenuation by fruit extract of Emblica officinalis (amla) in mice. Indian J Clin Biochem 2014; 29(1): 29-37.
[http://dx.doi.org/10.1007/s12291-013-0353-9] [PMID: 24478546]
[89]
Singh MK, Yadav SS, Gupta V, Khattri S. Immunomodulatory role of Emblica officinalis in arsenic induced oxidative damage and apoptosis in thymocytes of mice. BMC Complement Altern Med 2013; 13: 193.
[http://dx.doi.org/10.1186/1472-6882-13-193] [PMID: 23889914]
[90]
Singh MK, Yadav SS, Yadav RS, et al. Efficacy of crude extract of Emblica officinalis (amla) in arsenic-induced oxidative damage and apoptosis in splenocytes of mice. Toxicol Int 2014; 21(1): 8-17.
[http://dx.doi.org/10.4103/0971-6580.128784] [PMID: 24748729]
[91]
Bhattacharya S, Haldar PK. Ameliorative effect Trichosanthes dioica root against experimentally induced arsenic toxicity in male albino rats. Environ Toxicol Pharmacol 2012; 33(3): 394-402.
[http://dx.doi.org/10.1016/j.etap.2012.02.003] [PMID: 22387601]
[92]
Bhattacharya S, Haldar PK. Trichosanthes dioica fruit ameliorates experimentally induced arsenic toxicity in male albino rats through the alleviation of oxidative stress. Biol Trace Elem Res 2012; 148(2): 232-41.
[http://dx.doi.org/10.1007/s12011-012-9363-3] [PMID: 22383077]
[93]
Bhattacharya S, Das SK, Haldar PK. Arsenic induced myocardial toxicity in rats: alleviative effect of Trichosanthes dioica fruit. J Diet Suppl 2014; 11(3): 248-61.
[http://dx.doi.org/10.3109/19390211.2014.937044] [PMID: 25057964]
[94]
Das AK, Dewanjee S, Sahu R, Dua TK, Gangopadhyay M, Sinha MK. Protective effect of Corchorus olitorius leaves against arsenic-induced oxidative stress in rat brain. Environ Toxicol Pharmacol 2010; 29(1): 64-9.
[http://dx.doi.org/10.1016/j.etap.2009.10.002] [PMID: 21787584]
[95]
Das AK, Bag S, Sahu R, et al. Protective effect of Corchorus olitorius leaves on sodium arsenite-induced toxicity in experimental rats. Food Chem Toxicol 2010; 48(1): 326-35.
[http://dx.doi.org/10.1016/j.fct.2009.10.020] [PMID: 19852998]
[96]
Das AK, Sahu R, Dua TK, et al. Arsenic-induced myocardial injury: protective role of Corchorus olitorius leaves. Food Chem Toxicol 2010; 48(5): 1210-7.
[http://dx.doi.org/10.1016/j.fct.2010.02.012] [PMID: 20156518]
[97]
Flora SJS, Mehta A, Gupta R. Prevention of arsenic-induced hepatic apoptosis by concomitant administration of garlic extracts in mice. Chem Biol Interact 2009; 177(3): 227-33.
[http://dx.doi.org/10.1016/j.cbi.2008.08.017] [PMID: 18834867]
[98]
Chattopadhyay S, Maiti S, Maji G, Deb B, Pan B, Ghosh D. Protective role of Moringa oleifera (Sajina) seed on arsenic-induced hepatocellular degeneration in female albino rats. Biol Trace Elem Res 2011; 142(2): 200-12.
[http://dx.doi.org/10.1007/s12011-010-8761-7] [PMID: 20661662]
[99]
Tandon N, Roy M, Roy S, Gupta N. Protective effect of Psidium guajava in arsenic-induced oxidative stress and cytological damage in rats. Toxicol Int 2012; 19(3): 245-9.
[http://dx.doi.org/10.4103/0971-6580.103658] [PMID: 23293461]
[100]
Gbadegesin MA, Adegoke AM, Ewere EG, Odunola OA. Hepatoprotective and anticlastogenic effects of ethanol extract of Irvingia gabonensis (IG) leaves in sodium arsenite-induced toxicity in male Wistar rats. Niger J Physiol Sci 2014; 29(1): 29-36.
[PMID: 26196563]
[101]
Gora RH, Baxla SL, Kerketta P, Patnaik S, Roy BK. Hepatoprotective activity of Tephrosia purpurea against arsenic induced toxicity in rats. Indian J Pharmacol 2014; 46(2): 197-200.
[http://dx.doi.org/10.4103/0253-7613.129317] [PMID: 24741193]
[102]
Shafik NM, El Batsh MM. Protective effects of combined selenium and Punica granatum treatment on some inflammatory and oxidative stress markers in arsenic-induced hepatotoxicity in rats. Biol Trace Elem Res 2016; 169(1): 121-8.
[http://dx.doi.org/10.1007/s12011-015-0397-1] [PMID: 26085057]
[103]
Choudhury S, Ghosh S, Mukherjee S, et al. Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells. J Nutr Biochem 2016; 38: 25-40.
[http://dx.doi.org/10.1016/j.jnutbio.2016.09.001] [PMID: 27723467]
[104]
Oyagbemi AA, Omobowale TO, Ola-Davies OE, et al. Protective effect of Azadirachta indica and vitamin E against arsenic acid-induced genotoxicity and apoptosis in rats. J Diet Suppl 2018; 15(3): 251-68.
[http://dx.doi.org/10.1080/19390211.2017.1336147] [PMID: 28777671]
[105]
Kalantari H, Houshmand G, Hasanvand A, Kalantar M, Goudarzi M, Haghighian HK. Ameliorative effects of red lentil extract on sodium arsenite-induced oxidative stress in rats. Jundishapur J Nat Pharm Prod 2017; 12(Suppl. 3). e64309
[http://dx.doi.org/10.5812/jjnpp.64309]
[106]
Sharmila Banu G, Kumar G, Murugesan AG. Effects of leaves extract of Ocimum sanctum L. on arsenic-induced toxicity in Wistar albino rats. Food Chem Toxicol 2009; 47(2): 490-5.
[http://dx.doi.org/10.1016/j.fct.2008.12.004] [PMID: 19111884]
[107]
Chowdhury NJA, Misbahuddin M, Rahman MS. Corn extracts lower tissue arsenic level in rat. Bangladesh Med Res Counc Bull 2009; 35(1): 21-5.
[http://dx.doi.org/10.3329/bmrcb.v35i1.2533] [PMID: 19637542]
[108]
Gora RH, Kerketta P, Baxla SL, et al. Ameliorative effect of Tephrosia purpurea in arsenic-induced nephrotoxicity in rats. Toxicol Int 2014; 21(1): 78-83.
[http://dx.doi.org/10.4103/0971-6580.128807] [PMID: 24748739]
[109]
Jana S, Chattopadhyay S, Dey A, Perveen H, Dolai D. Involvement of metallothionein, homocysteine and B-vitamins in the attenuation of arsenic-induced uterine disorders in response to the oral application of hydro-ethanolic extract of Moringa oleifera seed: a preliminary study. Drug Chem Toxicol 2020; 43(1): 1-12.
[http://dx.doi.org/10.1080/01480545.2018.1508296] [PMID: 30208742]
[110]
Mundey MK, Roy M, Roy S, Awasthi MK, Sharma R. Antioxidant potential of Ocimum sanctum in arsenic induced nervous tissue damage. Braz J Vet Pathol 2013; 6(3): 95-101.
[111]
Mukherjee AA, Kandhare AD, Bodhankar SL. Elucidation of protective efficacy of Pentahydroxy flavone isolated from Madhuca indica against arsenite-induced cardiomyopathy: Role of Nrf-2, PPAR-γ, c-fos and c-jun. Environ Toxicol Pharmacol 2017; 56: 172-85.
[http://dx.doi.org/10.1016/j.etap.2017.08.027] [PMID: 28942082]
[112]
Samadder A, Das J, Das S, Khuda-Bukhsh AR. Dihydroxy-isosteviol-methyl-ester, an active biological component of Pulsatilla nigricans, reduces arsenic induced cellular dysfunction in testis of male mice. Environ Toxicol Pharmacol 2012; 34(3): 743-52.
[http://dx.doi.org/10.1016/j.etap.2012.09.013] [PMID: 23117066]
[113]
Akintude JK, Babaita AK. Effect of PUFAs from Pteleopsis suberosa steam bark on androgenic enzymes, cellular ATP and prostatic acid phosphatase in mercury chloride-exposed rats. Middle East Fertil Soc J 2017; 22(3): 211-8.
[http://dx.doi.org/10.1016/j.mefs.2017.02.005]
[114]
Barcelos GRM, Grotto D, Serpeloni JM, et al. Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo. Environ Mol Mutagen 2012; 53(7): 535-41.
[http://dx.doi.org/10.1002/em.21715] [PMID: 22847942]
[115]
Sumathi T, Shobana C, Christinal J, Anusha C. Protective effect of Bacopa monniera on methyl mercury-induced oxidative stress in cerebellum of rats. Cell Mol Neurobiol 2012; 32(6): 979-87.
[http://dx.doi.org/10.1007/s10571-012-9813-7] [PMID: 22366895]
[116]
Sumathi T, Christinal J. Neuroprotective effect of Portulaca oleraceae ethanolic extract ameliorates methylmercury induced cognitive dysfunction and oxidative stress in cerebellum and cortex of rat brain. Biol Trace Elem Res 2016; 172(1): 155-65.
[http://dx.doi.org/10.1007/s12011-015-0546-6] [PMID: 26563420]
[117]
Hallal N, Kharoubi O, Benyettou I, Tair K, Ozaslan M, Aoues AEK. In vivo amelioration of oxidative stress by Artemisia absinthium L. administration on mercuric chloride toxicity in brain regions. J Biol Sci 2016; 16(5): 167-77.
[http://dx.doi.org/10.3923/jbs.2016.167.177]
[118]
Kim W, Kim DW, Yoo DY, et al. Antioxidant effects of Dendropanax morbifera Léveille extract in the hippocampus of mercury-exposed rats. BMC Complement Altern Med 2015; 15: 247.
[http://dx.doi.org/10.1186/s12906-015-0786-1] [PMID: 26201852]
[119]
Bahi A, Necib Y. Protective effect of aqueous extract of Ajuga iva (L.) against mercury (II) induced oxidative and renal stress in rats. Int J Pharm Sci Rev Res 2014; 27(1): 111-6.
[120]
Necib Y, Bahi A. Aqueous extract of Cyperus rotundus rhizome protects against mercury (II) induced oxidative and renal stress in rats. Int J Pharm Pharm Sci 2014; 6(8): 610-4.
[121]
Necib Y, Bahi A, Zerizer S, et al. Effect of argan oil (Arginia spinosa L.) on kidney function impairment and oxidative stress induced by mercuric chloride in rats. Int J Pharm Sci Rev Res 2013; 22(2): 144-8.
[122]
Joshi D, Srivastav SK, Belemkar S, Dixit VA. Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach. Biomed Pharmacother 2017; 91: 645-55.
[http://dx.doi.org/10.1016/j.biopha.2017.04.108] [PMID: 28494418]
[123]
Bahi A, Necib Y. Hepatoprotective and antioxidant activity of aqueous extract of Cyperus rotundus rhizome against mercuric chloride induced oxidative stress in rats. Int J Pharm Sci Rev Res 2014; 27(1): 117-23.
[124]
Prasannaraj G, Jayaraj RL, Ravindar JD, Elangovan N. In vivo antioxidant potential of Thespesia populnea L., bark extract against mercury induced oxidative stress. Int J Pharm Res 2013; 5(4): 21-5.
[125]
Sathish Kumar T, Anandan A, Jegadeesan M. Identification of chemical compounds in Cissus quadrangularis L. Variant-I of different sample using GC-MS analysis. Arch Appl Sci Res 2012; 4(4): 1782-7.
[126]
Jayan N, Das S, Santhoshkumar R, Prince SE, Devi A. Hepatoprotective role of Cissus quadrangularis on lead acetate-induced liver injury in female wistar rats. Asian J Pharm Clin Res 2017; 10(11): 182-5.
[http://dx.doi.org/10.22159/ajpcr.2017.v10i11.20018]
[127]
El-Far AH, Korshom MA, Mandour AA, El-Bessoumy AA, El-Sayed YS. Hepatoprotective efficacy of Nigella sativa seeds dietary supplementation against lead acetate-induced oxidative damage in rabbit - Purification and characterization of glutathione peroxidase. Biomed Pharmacother 2017; 89: 711-8.
[http://dx.doi.org/10.1016/j.biopha.2017.02.044] [PMID: 28273633]
[128]
Butt UJ, Shah SAA, Ahmed T, Zahid S. Protective effects of Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models. Toxicol Res (Camb) 2017; 7(1): 32-40.
[129]
Tiruppur Venkatachallam SK, Pattekhan H, Divakar S, Kadimi US. Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide. J Food Sci Technol 2010; 47(6): 598-605.
[http://dx.doi.org/10.1007/s13197-010-0109-y] [PMID: 23572692]
[130]
Laamech J, El-Hilaly J, Fetoui H, et al. Berberis vulgaris L. effects on oxidative stress and liver injury in lead-intoxicated mice. J Complement Integr Med 2017; 114((1) pii: /j/jcim.2017.
[131]
Abd El-Wahab AE, Ghareeb DA, Sarhan EE, Abu-Serie MM, El Demellawy MA. In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects. BMC Complement Altern Med 2013; 13(13): 218.
[http://dx.doi.org/10.1186/1472-6882-13-218] [PMID: 24007270]
[132]
Shah F, Jain N. ameliorative action of synthetic and herbal antioxidants on lead induced hepatotoxicity: an in vitro study. Asian J Pharm Clin Res 2016; 9(2): 364-70.
[133]
Soussi A, Gargouri M, El Feki A. Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead-mediated hepatic damage and their interaction with lipase activity in rats. Environ Toxicol 2018; 33(12): 1261-71.
[http://dx.doi.org/10.1002/tox.22634] [PMID: 30251767]
[134]
Mostafa NM, Abd El-Ghffar EA, Hegazy HG, Eldahshan OA. New methoxyflavone from Casimiroa sapota and the biological activities of its leaves extract against lead acetate induced hepatotoxicity in rats. Chem Biodivers 2018; 15(4) e1700528
[http://dx.doi.org/10.1002/cbdv.201700528] [PMID: 29411525]
[135]
Rajan KE, Preethi J, Singh HK. Molecular and functional characterization of bacopa monniera: a retrospective review. Evid Based Complement Alternat Med 2015; 2015 945217
[http://dx.doi.org/10.1155/2015/945217] [PMID: 26413131]
[136]
Poggetti L, Ferfuia C, Chiabà C, Testolin R, Baldini M. Kernel oil content and oil composition in walnut (Juglans regia L.) accessions from north-eastern Italy. J Sci Food Agric 2018; 98(3): 955-62.
[http://dx.doi.org/10.1002/jsfa.8542] [PMID: 28703854]
[137]
Devi A, Jolitha AB, Ishii N. Grape seed proanthocyanidin extract (GSPE) and antioxidant defense in the brain of adult rats. Med Sci Monit 2006; 12(4): BR124-9.
[PMID: 16572044]
[138]
Liu B, Jiang H, Lu J, et al. Grape seed procyanidin extract ameliorates lead-induced liver injury via miRNA153 and AKT/GSK-3β/Fyn-mediated Nrf2 activation. J Nutr Biochem 2018; 52: 115-23.
[http://dx.doi.org/10.1016/j.jnutbio.2017.09.025] [PMID: 29175668]
[139]
Liu B, Zhang H, Tan X, et al. GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3β in rat kidney. Oncotarget 2017; 278(26): 42226-37.
[140]
Yang D, Li S, Gao L, et al. Dietary grape seed procyanidin extract protects against lead-induced heart injury in rats involving endoplasmic reticulum stress inhibition and AKT activation. J Nutr Biochem 2018; 62: 43-9.
[http://dx.doi.org/10.1016/j.jnutbio.2018.07.013] [PMID: 30245182]
[141]
Lu J, Jiang H, Liu B, et al. Grape seed procyanidin extract protects against Pb-induced lung toxicity by activating the AMPK/Nrf2/p62 signaling axis. Food Chem Toxicol 2018; 116(Pt B): 59-69.
[142]
Castrillejo VM, Romero MM, Esteve M, et al. Antioxidant effects of a grapeseed procyanidin extract and oleoyl-estrone in obese Zucker rats. Nutrition 2011; 27(11-12): 1172-6.
[http://dx.doi.org/10.1016/j.nut.2010.12.010] [PMID: 21497054]
[143]
Rauf A, Imran M, Abu-Izneid T, et al. Proanthocyanidins: A comprehensive review. Biomed Pharmacother 2019; 116 108999
[http://dx.doi.org/10.1016/j.biopha.2019.108999] [PMID: 31146109]
[144]
Liu CM, Ma JQ, Sun JM, et al. Association of changes in ER stress-mediated signaling pathway with lead-induced insulin resistance and apoptosis in rats and their prevention by A-type dimeric epigallocatechin-3-gallate. Food Chem Toxicol 2017; 110: 325-32.
[http://dx.doi.org/10.1016/j.fct.2017.10.040] [PMID: 29107025]
[145]
Long M, Liu Y, Cao Y, Wang N, Dang M, He J. Proanthocyanidins attenuation of chronic lead-induced liver oxidative damage in kunming mice via the Nrf2/ARE pathway. Nutrients 2016; 218(10) E656
[146]
Yang D, Jiang H, Lu J, et al. Dietary grape seed proanthocyanidin extract regulates metabolic disturbance in rat liver exposed to lead associated with PPARα signaling pathway. Environ Pollut 2018; 237: 377-87.
[http://dx.doi.org/10.1016/j.envpol.2018.02.035] [PMID: 29502000]
[147]
Koriem KMM, Arbid MS. Role of caftaric acid in lead-associated nephrotoxicity in rats via antidiuretic, antioxidant and antiapoptotic activities. J Complement Integr Med 2017; 1715(2) pii: /j/jcim.2018.15.
[148]
Al-Quraishy S, Dkhil MA, Ibrahim SR, Abdel Moneim AE. Neuroprotective potential of Indigofera oblongifolia leaf methanolic extract against lead acetate-induced neurotoxicity. Neural Regen Res 2016; 11(11): 1797-803.
[http://dx.doi.org/10.4103/1673-5374.194749] [PMID: 28123424]
[149]
Dkhil MA, Moneim AE, Al-Quraishy S. Indigofera oblongifolia ameliorates lead acetate-induced testicular oxidative damage and apoptosis in a rat model. Biol Trace Elem Res 2016; 173(2): 354-61.
[http://dx.doi.org/10.1007/s12011-016-0689-0] [PMID: 27052307]
[150]
Abdel Moneim AE. Indigofera oblongifolia prevents lead acetate-induced hepatotoxicity, oxidative stress, fibrosis and apoptosis in rats. PLoS One 2016; 11(7) e0158965
[http://dx.doi.org/10.1371/journal.pone.0158965] [PMID: 27391413]
[151]
Obafemi T, Onasanya A, Adeoye A, et al. Protective effect of methanolic and flavonoid-rich leaf extracts of Synsepalum dulcificum (Danielli) on lead-acetate-induced toxicity in Wistar albino rats. J Appl Pharm Sci 2019; 9(05): 65-72.
[http://dx.doi.org/10.7324/JAPS.2019.90508]
[152]
Kansal L, Sharma V, Sharma A, Lodi S, Sharma SH. protective role of Coriandrum sativum (coriander) extracts against lead nitrate induced oxidative stress and tissue damage in the liver and kidney in male mice. Int J Appl Biol Pharm Page 2011; 2(3): 66.
[153]
Mohamed WA, Abd-Elhakim YM, Farouk SM. Protective effects of ethanolic extract of rosemary against lead-induced hepato-renal damage in rabbits. Exp Toxicol Pathol 2016; 68(8): 451-61.
[http://dx.doi.org/10.1016/j.etp.2016.07.003] [PMID: 27449700]
[154]
El-Boshy ME, Refaat B, Qasem AH, et al. The remedial effect of Thymus vulgaris extract against lead toxicity-induced oxidative stress, hepatorenal damage, immunosuppression, and hematological disorders in rats. Environ Sci Pollut Res Int 2019; 26(22): 22736-46.
[http://dx.doi.org/10.1007/s11356-019-05562-8] [PMID: 31172438]
[155]
Chen CY, Wang YD, Wang HM. Chemical constituents from the leaves of Synsepalum dulcificum. Chem Nat Compd 2010; 46(3): 495.
[http://dx.doi.org/10.1007/s10600-010-9658-6]
[156]
Wangensteen H, Berit A, Karl S, Malterud E. Antioxidant activity in extracts from coriander. Food Chem 2004; 88(2): 293-7.
[http://dx.doi.org/10.1016/j.foodchem.2004.01.047]
[157]
Ho CT, Ferraro T, Chen Q, Rosen RT, Huang MT. Phytochemicals in teas and rosemary and their cancer-preventive properties. ACS Symp SerUSA. 1994; 2-19.
[http://dx.doi.org/10.1021/bk-1994-0547.ch001]
[158]
Habashy NH, Abu Serie M, Attia W. Chemical characterization, antioxidant and anti-inflammatory properties of Greek Thymus vulgaris extracts and their possible synergism with Egyptian Chlorella vulgaris. J Funct Foods 2018; 40: 317-28.
[http://dx.doi.org/10.1016/j.jff.2017.11.022]
[159]
Virk P, Elobeid M, Awad MA, Hendi AA, Ortashi KMO, Siddiqui MI. Characterization of nanorosemary and encapsulated rosemary nanoparticles and their effect on lead induced toxicity in Wistar rats. J Environ Biol 2017; 38: 1333-40.
[http://dx.doi.org/10.22438/jeb/38/6/MRN-490]
[160]
Bayan L, Koulivand PH, Gorji A. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed 2014; 4(1): 1-14.
[PMID: 25050296]
[161]
Martins N, Petropoulos S, Ferreira IC. Chemical composition and bioactive compounds of garlic (Allium sativum L.) as affected by pre- and post-harvest conditions: A review. Food Chem 2016; 211(211): 41-50.
[http://dx.doi.org/10.1016/j.foodchem.2016.05.029] [PMID: 27283605]
[162]
Galal MK, Elleithy EMM, Abdrabou MI, Yasin NAE, Shaheen YM. Modulation of caspase-3 gene expression and protective effects of garlic and spirulina against CNS neurotoxicity induced by lead exposure in male rats. Neurotoxicology 2019; 72: 15-28.
[http://dx.doi.org/10.1016/j.neuro.2019.01.006] [PMID: 30703413]
[163]
Manoj Kumar V, Henley AK, Nelson CJ, et al. Protective effect of Allium sativum (garlic) aqueous extract against lead-induced oxidative stress in the rat brain, liver, and kidney. Environ Sci Pollut Res Int 2017; 24(2): 1544-52.
[http://dx.doi.org/10.1007/s11356-016-7923-3] [PMID: 27785721]
[164]
Abdrabou MI, Elleithy EMM, Yasin NAE, Shaheen YM, Galal M. Ameliorative effects of Spirulina maxima and Allium sativum on lead acetate-induced testicular injury in male albino rats with respect to caspase-3 gene expression. Acta Histochem 2019; 121(2): 198-206.
[http://dx.doi.org/10.1016/j.acthis.2018.12.006] [PMID: 30587387]
[165]
Gonthier MP, Remesy C, Scalbert A, et al. Microbial metabolism of caffeic acid and its esters chlorogenic and caftaric acids by human faecal microbiota in vitro. Biomed Pharmacother 2006; 60(9): 536-40.
[http://dx.doi.org/10.1016/j.biopha.2006.07.084] [PMID: 16978827]
[166]
Farag MR, Alagawany M, Abd El-Hack ME, El-Sayed SAA, Ahmed SYA, Samak DH. Yucca schidigera extract modulates the lead-induced oxidative damage, nephropathy and altered inflammatory response and glucose homeostasis in Japanese quails. Ecotoxicol Environ Saf 2018; 156(156): 311-21.
[http://dx.doi.org/10.1016/j.ecoenv.2018.03.010] [PMID: 29571109]
[167]
Alagawany M, Abd El-Hack ME, Farag MR, et al. Dietary supplementation of Yucca schidigera extract enhances productive and reproductive performances, blood profile, immune function, and antioxidant status in laying Japanese quails exposed to lead in the diet. Poult Sci 2018; 197(9): 3126-37.
[168]
Chrenkova ML, Chrastinova M, Polacikova Z, Formelova Z, Balazi A, Ondruska L, et al. The effect of Yucca schidigera extract in diet of rabbits on nutrient digestibility and qualitative parameters in caecum. Slovak J Anim Sci 2012; 45: 83-8.
[169]
Bhatti S, Ali Shah SA, Ahmed T, Zahid S. Neuroprotective effects of Foeniculum vulgare seeds extract on lead-induced neurotoxicity in mice brain. Drug Chem Toxicol 2018; 41(4): 399-407.
[http://dx.doi.org/10.1080/01480545.2018.1459669] [PMID: 29742941]
[170]
Chintapanti S, Pratap Reddy K, Sreenivasula Reddy P. Behavioral and neurochemical consequences of perinatal exposure to lead in adult male Wistar rats: protective effect by Centella asiatica. Environ Sci Pollut Res Int 2018; 25(13): 13173-85.
[http://dx.doi.org/10.1007/s11356-018-1500-x] [PMID: 29492815]
[171]
Xue WZ, Yang QQ, Chen Y, et al. Kiwifruit alleviates learning and memory deficits induced by pb through antioxidation and inhibition of microglia activation in vitro and in vivo. Oxid Med Cell Longev 2017; 2017 5645324
[http://dx.doi.org/10.1155/2017/5645324] [PMID: 28386309]
[172]
Liu D, Mao Y, Ding L, Zeng XA. Dihydromyricetin: A review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its bioavailability. Trends Food Sci Technol 2019; 91: 586-97.
[http://dx.doi.org/10.1016/j.tifs.2019.07.038]
[173]
Alam P, Abdel-Kader MS, Alqarni MH, Zaatout HH, Ahamad SR, Shakeel F. Chemical composition of fennel seed extract and determination of fenchone in commercial formulations by GC-MS method. J Food Sci Technol 2019; 56(5): 2395-403.
[http://dx.doi.org/10.1007/s13197-019-03695-9] [PMID: 31168122]
[174]
Siddiqui BS, Aslam H, Ali ST, Khan S, Begum S. Chemical constituents of Centella asiatica. J Asian Nat Prod Res 2007; 9(3-5): 407-14.
[http://dx.doi.org/10.1080/10286020600782454] [PMID: 17613628]
[175]
He X, Fang J, Chen X, et al. Actinidia chinensis Planch.: A review of chemistry and pharmacology. Front Pharmacol 2019; 10: 1236.
[http://dx.doi.org/10.3389/fphar.2019.01236] [PMID: 31736750]
[176]
Liu CM, Yang W, Ma JQ, et al. The effectiveness of chitosan- pinus merkusii extract nanoparticle as antioxidant and anti-caspase 3 in against lead acetate toxicity on the lung of wistar rat. Indian J Pharm Educ 2018; 53(2): 135-42.
[177]
Sudjarwo SA, Wardani G, Eraiko K. Koerniasari, Ernawati. The effectiveness of chitosan- pinus merkusii extract nanoparticle as antioxidant and anti-caspase 3 in against lead acetate toxicity on the lung of wistar rat. Indian J Pharm Educ 2019; 53(2)(Suppl.): 135-42.
[http://dx.doi.org/10.5530/ijper.53.2s.58]
[178]
Gargouri M, Hamed H, Akrouti A, Christian M, Ksouri R, El Feki A. Immunomodulatory and antioxidant protective effect of Sarcocornia perennis L. (swampfire) in lead intoxicated rat. Toxicol Mech Methods 2017; 27(9): 697-706.
[http://dx.doi.org/10.1080/15376516.2017.1351018] [PMID: 28675318]
[179]
Okesola MA, Ajiboye BO, Oyinloye BE, Ojo OA. Effect of Zingiber officinale on some biochemical parameters and cytogenic analysis in lead-induced toxicity in experimental rats. Toxicol Mech Methods 2019; 29(4): 255-62.
[http://dx.doi.org/10.1080/15376516.2018.1558321] [PMID: 30558515]
[180]
Hayet G, Hamadouche Nadia A, Omar K, Aek A. Green tea protective effect against lead acetate inducing reprotoxic effects in male rats. Res J Pharm Biol Chem Sci 2016; 7(6): 2457-64.
[181]
Soliman G, Ganaie M, Althurwi H, Albaqami F, Salkini M, Abdel-Kader M. Extract of Salvadora persica roots attenuates lead acetate-induced testicular oxidative stress in rats. J Pharm Pharmacogn Res 2017; 5(4): 238-50.
[182]
Sudjarwo SA, Sudjarwo GW, Koerniasari . Protective effect of curcumin on lead acetate-induced testicular toxicity in Wistar rats. Res Pharm Sci 2017; 12(5): 381-90.
[http://dx.doi.org/10.4103/1735-5362.213983] [PMID: 28974976]
[183]
Grzanna R, Lindmark L, Frondoza CG. Ginger--an herbal medicinal product with broad anti-inflammatory actions. J Med Food 2005; 8(2): 125-32.
[http://dx.doi.org/10.1089/jmf.2005.8.125] [PMID: 16117603]

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