The Potential Prognostic Performance of Neutrophil CD64 and Monocyte HLA-DR in Patients with Complicated Intra-abdominal Infections

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Author(s): Evgeni Dimitrov*, Krasimira Halacheva, Emil Enchev, Georgi Minkov, Yovcho Yovtchev.

Journal Name: Current Immunology Reviews

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Background: Complicated intra-abdominal infections are still associated with high risk of unfavorable outcome. Despite the equal treatment the mortality rates in some patients’ populations remain significant, especially when impaired immune response is present.

Aim: To analyze the impact of pro-inflammatory neutrophil CD64 and anti-inflammatory monocyte HLA-DR on the final outcome.

Methods: We have searched in PubMed database the literature relating the prognostic value of two biomarkers - nCD64 and mHLA-DR in patients with complicated intra-abdominal infections and/or sepsis.

Results: Eighteen original studies with 2960 patients fulfilled our inclusion criteria. The data about nCD64 that we found was contradictory, whereas low mHLA-DR expression showed good prognostic value.

Conclusion: Our review showed heterogenous data about nCD64 survival prediction. Further investigations with surgical patients exclusively are needed to evaluate its prognostic value in cIAIs. However, we observed a good prognostic performance of low mHLA-DR expression. After a validation in larger multicentre studies mHLA-DR could be used as promising prognostic biomarker in cIAIs.

Keywords: intra-abdominal infections, CD64, HLA-DR, sepsis, outcome, mortality

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1573395516666200312111456
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