Most of the clinical approved protein-based drugs or under clinical trials have a profound
impact on the treatment of critical diseases. The mammalian eukaryotic cells culture approaches,
particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical
industry for the mass-production of the therapeutic protein. Recent advances in CHO cell
bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression
of quality protein. The developments of cell lines are possible to enhance specific productivity.
As a result, it holds an interesting area for academic as well as industrial researchers around the
world. This review will focus on the recent progress of the mammalian CHO cells culture technology
and the future scope of further development for the mass-production of protein therapeutics.
Keywords: Therapeutic protein, mammalian cells, CHO cells, protein expression, bio-processing, mass-production.
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