Abstract
Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and differentiation features in multi-step tumorigenesis, tumor recurrence and metastasis. Proinflammatory stress is highly associated with cancer stemness via induction of cytokines, tumorpromoting immune cells and cancer stemness-related signaling pathways. This review summarizes the major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic strategies to eliminate cancer stem cells.
Keywords: Inflammation, cancer stemness, pro-inflammatory stress, cancer stem cells, pro-inflammatory cytokines, immunotherapeutic strategies.
Current Stem Cell Research & Therapy
Title:Cancer Stemness as a Target for Immunotherapy is Shaped by Proinflammatory Stress
Volume: 16 Issue: 7
Author(s): Nese Unver*
Affiliation:
- Department of Stem Cell Sciences, Graduate School of Health Sciences, Center for Stem Cell Research and Development, Hacettepe University, Sihhiye, 06100, Ankara,Turkey
Keywords: Inflammation, cancer stemness, pro-inflammatory stress, cancer stem cells, pro-inflammatory cytokines, immunotherapeutic strategies.
Abstract: Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and differentiation features in multi-step tumorigenesis, tumor recurrence and metastasis. Proinflammatory stress is highly associated with cancer stemness via induction of cytokines, tumorpromoting immune cells and cancer stemness-related signaling pathways. This review summarizes the major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic strategies to eliminate cancer stem cells.
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Cite this article as:
Unver Nese *, Cancer Stemness as a Target for Immunotherapy is Shaped by Proinflammatory Stress, Current Stem Cell Research & Therapy 2021; 16 (7) . https://dx.doi.org/10.2174/1574888X15666200309145901
DOI https://dx.doi.org/10.2174/1574888X15666200309145901 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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