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Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

General Research Article

Association of Interleukin-1 and Inteleukin-1 Receptor Antagonist Gene Polymorphisms with Multiple Sclerosis in Azeri Population of Iran

Author(s): Mohammad Asgharzadeh, Zahra A. Jigheh, Hossein S. Kafil, Mehdi Farhoudi, Daryoush S. Oskouei, Fatemeh Khaki-Khatibi, Manouchehr Fadaee , Ali Vegari, Vahid Asgharzadeh, Nima Najafi-Ghalelou, Behroz M. Poor and Jalil Rashedi*

Volume 20, Issue 7, 2020

Page: [1110 - 1116] Pages: 7

DOI: 10.2174/1871530320666200309142541

Price: $65

Abstract

Background: Cytokines as important mediators have a critical role in appropriate immune responses, the irregular production of which can lead to Multiple Sclerosis (MS). Proinflammatory cytokine interleukin-1 (IL-1) triggers inflammatory responses. Function and production of the cytokine are influenced by IL-1 coding gene polymorphism and those antagonists gene polymorphism.

Objective: The aim of the present study was to evaluate the possible correlation between MS and IL-1 related alleles in Azeri population of Iran.

Methods: Variable number tandem repeats (VNTR) genotypes of 150 MS patients and 220 healthy non-relative controls were determined.

Results: In the healthy controls, genotype TT at IL-1A (-889) location was significantly higher than the MS patients (p=0.0001). However, a significant difference was not found between the two groups in genotypic/allelic frequency at IL- 1B+ 3953 location. Evaluation of the IL-1RA gene revealed that genotype 1/2, and genotype 1/3 were significantly higher in the healthy controls and MS patients, respectively. Our findings indicated that the consumption of fast-food in MS patients was significantly higher than controls (p= <0.05). Also, a considerable number of MS patients had inappropriate dieting behaviors such as not eating breakfast (p= 0.0001), and irregular eating habits (p= 0.0001).

Conclusion: Polymorphisms of the IL-1B genes and common alleles of IL-1RA were not considered as risk factors for MS disease. However, genotype TT at IL-1A (-889) location and the rare allele of IL-1RA3 can be a potential risk factor for the disease. Furthermore, inappropriate dieting behaviors and consumption of fast-food can increase the risk of MS.

Keywords: IL-1A, IL-1B, IL-1RA, polymorphism, multiple sclerosis, Iran.

Graphical Abstract
[1]
Moosazadeh, M.; Esmaeili, R.; Mehdi Nasehi, M.; Abedi, G.; Afshari, M.; Farshidi, F.; Kheradmand, M. Prevalence of familial multiple sclerosis in Iran: A systematic review and meta-analysis. Iran. J. Neurol., 2017, 16(2), 90-95.
[PMID: 28761631]
[2]
Sahraian, M.A.; Sahebkar, M.; Dehghani, R.; Derakhshan-Jazari, M.; Kazami-Moghaddam, V.; Kouchaki, E. Multiple sclerosis-A disease on a dramatically rising trend in Iran: Review of possible reasons. Iran. J. Neurol., 2017, 16(1), 34-40.
[PMID: 28717432]
[3]
Browne, P.; Chandraratna, D.; Angood, C.; Tremlett, H.; Baker, C.; Taylor, B.V.; Thompson, A.J. Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity. Neurology, 2014, 83(11), 1022-1024.
[http://dx.doi.org/10.1212/WNL.0000000000000768] [PMID: 25200713]
[4]
Abdollahpour, I.; Nedjat, S.; Mansournia, M.A.; Sahraian, M.A.; Asgari, N. Parental ethnicity associated with risk for multiple sclerosis: A population-based incident case-control study in Iran. Mult. Scler. Relat. Disord., 2018, 20, 100-103.
[http://dx.doi.org/10.1016/j.msard.2018.01.008] [PMID: 29353734]
[5]
Agnello, L.; Scazzone, C.; Ragonese, P.; Salemi, G.; Lo Sasso, B.; Schillaci, R.; Musso, G.; Bellia, C.; Ciaccio, M. Vitamin D receptor polymorphisms and 25-hydroxyvitamin D in a group of Sicilian multiple sclerosis patients. Neurol. Sci., 2016, 37(2), 261-267.
[http://dx.doi.org/10.1007/s10072-015-2401-0] [PMID: 26506927]
[6]
Legroux, L.; Arbour, N. Multiple Sclerosis and T Lymphocytes: An Entangled Story. J. Neuroimmune Pharmacol., 2015, 10(4), 528-546.
[http://dx.doi.org/10.1007/s11481-015-9614-0] [PMID: 25946987]
[7]
Mirowska-Guzel, D.; Gromadzka, G.; Mach, A.; Czlonkowski, A.; Czlonkowska, A. Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-α polymorphisms with risk and clinical course of multiple sclerosis in a Polish population. J. Neuroimmunol., 2011, 236(1-2), 87-92.
[http://dx.doi.org/10.1016/j.jneuroim.2011.04.014] [PMID: 21621860]
[8]
Schrijver, H.M.; van As, J.; Crusius, J.B.A.; Dijkstra, C.D.; Uitdehaag, B.M. Interleukin (IL)-1 gene polymorphisms: relevance of disease severity associated alleles with IL-1beta and IL-1ra production in multiple sclerosis. Mediators Inflamm., 2003, 12(2), 89-94.
[http://dx.doi.org/10.1080/0962933031000097691] [PMID: 12775358]
[9]
Paré, A.; Mailhot, B.; Lévesque, S.A.; Lacroix, S. Involvement of the IL-1 system in experimental autoimmune encephalomyelitis and multiple sclerosis: Breaking the vicious cycle between IL-1β and GM-CSF. Brain Behav. Immun., 2017, 62, 1-8.
[http://dx.doi.org/10.1016/j.bbi.2016.07.146] [PMID: 27432634]
[10]
Palomo, J.; Dietrich, D.; Martin, P.; Palmer, G.; Gabay, C. The interleukin (IL)-1 cytokine family--Balance between agonists and antagonists in inflammatory diseases. Cytokine, 2015, 76(1), 25-37.
[http://dx.doi.org/10.1016/j.cyto.2015.06.017] [PMID: 26185894]
[11]
Isik, N.; Arman, A.; Canturk, I.A.; Gurkan, A.C.; Candan, F.; Aktan, S.; Erzaim, N.; Duz, O.A.; Aydin, T.; Turkes, M.; List, E.O. Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population. Int. J. Neurosci., 2013, 123(10), 711-718.
[http://dx.doi.org/10.3109/00207454.2013.795563] [PMID: 23594042]
[12]
García-González, M.A.; Aísa, M.A.; Strunk, M.; Benito, R.; Piazuelo, E.; Jiménez, P.; Sopeña, F.; Lanas, A. Relevance of IL-1 and TNF gene polymorphisms on interleukin-1beta and tumor necrosis factor-alpha gastric mucosal production. Hum. Immunol., 2009, 70(11), 935-945.
[http://dx.doi.org/10.1016/j.humimm.2009.07.024] [PMID: 19664671]
[13]
Tarlow, J.K.; Blakemore, A.I.; Lennard, A.; Solari, R.; Hughes, H.N.; Steinkasserer, A.; Duff, G.W. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum. Genet., 1993, 91(4), 403-404.
[http://dx.doi.org/10.1007/BF00217368] [PMID: 8500797]
[14]
Khosravi, A.; Javan, B.; Tabatabaiefar, M.A.; Ebadi, H.; Fathi, D.; Shahbazi, M. Association of interleukin-1 gene cluster polymorphisms and haplotypes with multiple sclerosis in an Iranian population. J. Neuroimmunol., 2015, 288, 114-119.
[http://dx.doi.org/10.1016/j.jneuroim.2015.09.009] [PMID: 26531703]
[15]
Asgharzadeh, M.; Ghorghanlu, S.; Rashedi, J.; Mahdavi Poor, B.; Khaki-Khatibi, F.; Moaddab, S.R.; Samadi-Kafil, H.; Pourostadi, M. Association of Promoter Polymorphisms of Interleukin-10 and Interferon-Gamma Genes with Tuberculosis in Azeri Population of Iran. Iran. J. Allergy Asthma Immunol., 2016, 15(3), 167-173.
[PMID: 27424131]
[16]
Kornman, K.S.; Crane, A.; Wang, H.Y.; di Giovine, F.S.; Newman, M.G.; Pirk, F.W.; Wilson, T.G., Jr; Higginbottom, F.L.; Duff, G.W. The interleukin-1 genotype as a severity factor in adult periodontal disease. J. Clin. Periodontol., 1997, 24(1), 72-77.
[http://dx.doi.org/10.1111/j.1600-051X.1997.tb01187.x] [PMID: 9049801]
[17]
Bioque, G.; Crusius, J.B.A.; Koutroubakis, I.; Bouma, G.; Kostense, P.J.; Meuwissen, S.G.M.; Peña, A.S. Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease. Clin. Exp. Immunol., 1995, 102(2), 379-383.
[http://dx.doi.org/10.1111/j.1365-2249.1995.tb03793.x] [PMID: 7586694]
[18]
de Jong, B.A.; Huizinga, T.W.; Bollen, E.L.; Uitdehaag, B.M.; Bosma, G.P.; van Buchem, M.A.; Remarque, E.J.; Burgmans, A.C.; Kalkers, N.F.; Polman, C.H.; Westendorp, R.G. Production of IL-1beta and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis. J. Neuroimmunol., 2002, 126(1-2), 172-179.
[http://dx.doi.org/10.1016/S0165-5728(02)00056-5] [PMID: 12020968]
[19]
Sarial, S.; Shokrgozar, M.A.; Amirzargar, A.; Shokri, F.; Radfar, J.; Zohrevand, P.; Arjang, Z.; Sahraian, M.A.; Lotfi, J. IL-1, IL-1R and TNFalpha gene polymorphisms in Iranian patients with multiple sclerosis. Iran. J. Allergy Asthma Immunol., 2008, 7(1), 37-40.
[PMID: 18322311]
[20]
Ferri, C.; Sciacca, F.L.; Grimaldi, L.E.; Veglia, F.; Magnani, G.; Santuccio, G.; Comi, G.; Canal, N.; Grimaldi, L.M. Lack of association between IL-1A and IL-1B promoter polymorphisms and multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 2000, 69(4), 564-565.
[http://dx.doi.org/10.1136/jnnp.69.4.564] [PMID: 11183041]
[21]
Hooper-van Veen, T.; Schrijver, H.M.; Zwiers, A.; Crusius, J.B.; Knol, D.L.; Kalkers, N.F.; Laine, M.L.; Barkhof, F.; Peña, A.S.; Polman, C.H.; Uitdehaag, B.M. The interleukin-1 gene family in multiple sclerosis susceptibility and disease course. Mult. Scler., 2003, 9(6), 535-539.
[http://dx.doi.org/10.1191/1352458503ms974oa] [PMID: 14664464]
[22]
Dominici, R.; Cattaneo, M.; Malferrari, G.; Archi, D.; Mariani, C.; Grimaldi, L.M.; Biunno, I. Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1 alpha. Immunogenetics, 2002, 54(2), 82-86.
[http://dx.doi.org/10.1007/s00251-002-0445-9] [PMID: 12037600]
[23]
Heidary, M.; Rakhshi, N.; Pahlevan Kakhki, M.; Behmanesh, M.; Sanati, M.H.; Sanadgol, N.; Kamaladini, H.; Nikravesh, A. The analysis of correlation between IL-1B gene expression and genotyping in multiple sclerosis patients. J. Neurol. Sci., 2014, 343(1-2), 41-45.
[http://dx.doi.org/10.1016/j.jns.2014.05.013] [PMID: 24867167]
[24]
Dujmovic, I.; Mangano, K.; Pekmezovic, T.; Quattrocchi, C.; Mesaros, S.; Stojsavljevic, N.; Nicoletti, F.; Drulovic, J. The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: The elevation of IL-1 receptor antagonist and IL-1 receptor type II after steroid therapy. J. Neuroimmunol., 2009, 207(1-2), 101-106.
[http://dx.doi.org/10.1016/j.jneuroim.2008.11.004] [PMID: 19162335]
[25]
Gore, E.A.; Sanders, J.J.; Pandey, J.P.; Palesch, Y.; Galbraith, G.M.P. Interleukin-1beta+3953 allele 2: association with disease status in adult periodontitis. J. Clin. Periodontol., 1998, 25(10), 781-785.
[http://dx.doi.org/10.1111/j.1600-051X.1998.tb02370.x] [PMID: 9797049]
[26]
Kantarci, O.H.; Atkinson, E.J.; Hebrink, D.D.; McMurray, C.T.; Weinshenker, B.G. Association of two variants in IL-1beta and IL-1 receptor antagonist genes with multiple sclerosis. J. Neuroimmunol., 2000, 106(1-2), 220-227.
[http://dx.doi.org/10.1016/S0165-5728(00)00202-2] [PMID: 10814801]
[27]
Aggelakis, K.; Zacharaki, F.; Dardiotis, E.; Xiromerisiou, G.; Tsimourtou, V.; Ralli, S.; Gkaraveli, M.; Bourpoulas, D.; Rodopoulou, P.; Papadimitriou, A.; Hadjigeorgiou, G. Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms in Greek multiple sclerosis (MS) patients with bout-onset MS. Neurol. Sci., 2010, 31(3), 253-257.
[http://dx.doi.org/10.1007/s10072-009-0155-2] [PMID: 19876593]
[28]
Hurme, M.; Santtila, S. IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes. Eur. J. Immunol., 1998, 28(8), 2598-2602.
[http://dx.doi.org/10.1002/(SICI)1521-4141(199808)28:08<2598:AID-IMMU2598>3.0.CO;2-K] [PMID: 9710237]
[29]
Bhargava, P.; Mowry, E.M. Gut microbiome and multiple sclerosis. Curr. Neurol. Neurosci. Rep., 2014, 14(10), 492.
[http://dx.doi.org/10.1007/s11910-014-0492-2] [PMID: 25204849]
[30]
David, L.A.; Maurice, C.F.; Carmody, R.N.; Gootenberg, D.B.; Button, J.E.; Wolfe, B.E.; Ling, A.V.; Devlin, A.S.; Varma, Y.; Fischbach, M.A.; Biddinger, S.B.; Dutton, R.J.; Turnbaugh, P.J. Diet rapidly and reproducibly alters the human gut microbiome. Nature, 2014, 505(7484), 559-563.
[http://dx.doi.org/10.1038/nature12820] [PMID: 24336217]
[31]
Huitema, M.J.D.; Schenk, G.J. Insights into the Mechanisms That May Clarify Obesity as a Risk Factor for Multiple Sclerosis. Curr. Neurol. Neurosci. Rep., 2018, 18(4), 18.
[http://dx.doi.org/10.1007/s11910-018-0827-5] [PMID: 29525910]
[32]
Issazadeh-Navikas, S.; Teimer, R.; Bockermann, R. Influence of dietary components on regulatory T cells. Mol. Med., 2012, 18(1), 95-110.
[http://dx.doi.org/10.2119/molmed.2011.00311] [PMID: 22113499]

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