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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Discovery of Anticancer Agents from 2-Pyrazoline-Based Compounds

Author(s): Qing-Shan Li*, Bang-Nian Shen, Zhen Zhang, Shuying Luo* and Ban-Feng Ruan*

Volume 28, Issue 5, 2021

Published on: 06 March, 2020

Page: [940 - 962] Pages: 23

DOI: 10.2174/0929867327666200306120151

Price: $65

Abstract

As nitrogen-containing five-membered heterocyclic structural units, the substituted pyrazole derivatives have a broad spectrum of pharmacological activities, especially 4,5-dihydro-1H-pyrazoles that also commonly known as 2-pyrazolines. Since 2010, considerable studies have been found that the 2-pyrazoline derivatives possess potent anticancer activities. In the present review, it covers the pyrazoline derivatives reported by literature from 2010 till date (2010-2019). This review aims to establish the relationship between the anticancer activities variation and different substituents introduced into a 2-pyrazoline core, which could provide important pharmacophore clues for the discovery of new anticancer agents containing 2-pyrazoline scaffold.

Keywords: 2-pyrazoline, 4, 5-dihydro-1H-pyrazole, derivatives, anticancer activities, synthesis, SAR, Nitrogencontaining heterocyclic structural units.

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