Toxicity Evaluation of the Subacute Diazinon in Aged Male Rats: Hematological Aspects

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Author(s): Saeed Samarghandian, Tahereh Farkhondeh, Shahnaz Yousefizadeh*.

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

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Background & Objective: Age-dependent organophosphates (OPs) toxicity is a controversial topic. The present study was designed to investigate the effect of the sub-acute exposure to diazinon (DZN), one of the main OPs insecticides, on the hematological alterations in adult and aged male rats.

Methods: For approach to this aim, the adult and aged rats were received DZN (15 mg/kg, orally) for 4 weeks. Then, the blood samples were collected from the retro-orbital sinus for measuring red blood cell (RBC), hemoglobin (Hb), hematocrit (Hct), platelets (PLT), MCV (mean corpuscular volume), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin (MCHC).

Results: The obtained results indicated that DZN significantly decreased RBCs (4.93 ± 0.41), Htc (28.12 ± 1.21), Hb (10.31 ± 0.36), MCHC (30.51 ± 2.04), MCV (62.86 ± 2.58), and PLT (265.6 ± 34.81) values in the adult and aged rats versus the age-matched control rats. Moreover, RBC, Hb, and Htc levels decreased significantly in the aged rats versus adult rats. However, no significant differences observed between MCHC, MCV, and PLT levels in adult and aged rats. Also, the MCH concentration did not change in any groups. Additionally, DZN did not deteriorate the hematological alterations in the aged rats versus adult rats.

Conclusion: The present study showed that toxicity of DZN is not associated to age. However, more studies should be done to confirm this finding.

Keywords: Hematology, adule, age, rat, diazinon, neurodegenerative, inflammation

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(E-pub Ahead of Print)
DOI: 10.2174/1871529X20666200305103007