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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

Therapeutic Strategies to Protect the Central Nervous System against Shiga Toxin from Enterohemorrhagic Escherichia coli

Author(s): Jorge Goldstein*, Krista Nuñez-Goluboay and Alipio Pinto*

Volume 19, Issue 1, 2021

Published on: 20 February, 2020

Page: [24 - 44] Pages: 21

DOI: 10.2174/1570159X18666200220143001

Price: $65

Abstract

Infection with Shiga toxin-producing Escherichia coli (STEC) may cause hemorrhagic colitis, hemolytic uremic syndrome (HUS) and encephalopathy. The mortality rate derived from HUS adds up to 5% of the cases, and up to 40% when the central nervous system (CNS) is involved. In addition to the well-known deleterious effect of Stx, the gram-negative STEC releases lipopolysaccharides (LPS) and may induce a variety of inflammatory responses when released in the gut. Common clinical signs of severe CNS injury include sensorimotor, cognitive, emotional and/or autonomic alterations. In the last few years, a number of drugs have been experimentally employed to establish the pathogenesis of, prevent or treat CNS injury by STEC. The strategies in these approaches focus on: 1) inhibition of Stx production and release by STEC, 2) inhibition of Stx bloodstream transport, 3) inhibition of Stx entry into the CNS parenchyma, 4) blockade of deleterious Stx action in neural cells, and 5) inhibition of immune system activation and CNS inflammation. Fast diagnosis of STEC infection, as well as the establishment of early CNS biomarkers of damage, may be determinants of adequate neuropharmacological treatment in time.

Keywords: Neurodegeneration, neuroprotection, neuropharmacology, reactive astrocytes, microvasculature, oligodendrocytes, microglial cells, Shiga toxin 2, images, brain, cerebellum, transmission electron microscopy, fluorescence microscopy, lipopolysaccharides, inflammation, Hemolytic Uremic Syndrome.

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