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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Research Article

Barium- and Bismuth-loaded Clinoptilolite Micro- and Nano-Particles as Proposed New Efficient Contrast Agents

Author(s): Asieh Hosseini, Alireza Ebadollahi-Natanzi, Mohammad Foroughi and Seyed V. Shetab-Boushehri*

Volume 23, Issue 3, 2020

Page: [191 - 195] Pages: 5

DOI: 10.2174/1386207323666200218113537

Price: $65

Abstract

Aims and Objective: Clinoptilolite is one of the natural zeolites. Clinoptilolite particles have a high surface area, negative surface charge, cation adsorption and exchange capacities. Barium sulfate (BaSO4) and bismuth subnitrate (Bi5H9N4O22) suspensions have been used for upper and lower gastrointestinal imaging but Ba2+ and Bi3+ ions are toxic. In the present study, the feasibility of the application of Ba2+- and Bi3+-loaded clinoptilolite micro- and nano-particles in medical imaging was investigated.

Materials and Methods: Nanoparticles and microparticles of natural clinoptilolite were loaded with Ba2+ and Bi3+ ions. Radiopacities of loaded particles were measured and compared with those of BaSO4 and Bi5H9N4O22.

Results: Ba2+- and Bi3+-loaded clinoptilolite nanoparticles and microparticles showed more intense X-ray opacities than BaSO4 and Bi5H9N4O22 with equimolar concentrations. Moreover, Ba2+- and Bi3+-loaded clinoptilolite nanoparticles more intensely absorbed X-ray than respective loaded microparticles.

Conclusion: The present study proposes Ba2+- and Bi3+-loaded clinoptilolite nanoparticles and microparticles as new, safe, efficient, and inexpensive contrast agents.

Keywords: Contrast agent, nanoparticles, microparticles, clinoptilolite zeolite, barium sulfate, bismuth subnitrate.

« Previous Next »
[1]
Faghihian, H.; Marageh, M.G.; Kazemian, H. The use of clinoptilolite and its sodium form for removal of radioactive cesium, and strontium from nuclear wastewater and Pb2+, Ni2+, Cd2+, Ba2+ from municipal wastewater. Appl. Radiat. Isot., 1999, 50(4), 655-660.
[http://dx.doi.org/10.1016/S0969-8043(98)00134-1] [PMID: 10101831]
[2]
Mansouri, N.; Rikhtegar, N.; Ahmad Panahi, H.; Atabi, F.; Karimi Shahraki, B. Porosity, characterization and structural properties of natural zeolite- clinoptilolite- as a sorbent. Environ. Prot. Eng., 2013, 39(1), 139-152.
[3]
Sadeghi, A.A.; Shawrang, P. Effects of natural zeolite clinoptilolite on passive immunity and diarrhea in newborn Holstein calves. Livest. Sci., 2018, 113(2-3), 307-310.
[http://dx.doi.org/10.1016/j.livsci.2007.08.010]
[4]
Baerlocher, C.; McCusker, L.B.; Olson, D.H. Atlas of Zeolite Framework Types, 6th ed; Elsevier: Amsterdam, 2007.
[5]
Colella, C. Recent Advances in Natural Zeolite Applications Based on External Surface Interaction with Cations and Molecules. In: Studies in Surface Science and Catalysis, 1st ed; Xu, R.; Gao, Z.; Chen, J.; Yan, W., Eds.; Elsevier: Amsterdam, 2007; Vol 170, pp. 2063-2073.
[6]
Tondar, M.; Parsa, M.J.; Yousefpour, Y.; Sharifi, A.M.; Shetab-Boushehri, S.V. Feasibility of clinoptilolite application as a microporous carrier for pH-controlled oral delivery of aspirin. Acta Chim. Slov., 2014, 61(4), 688-693.
[PMID: 25551707]
[7]
Tondar, M.; Jambar-Nooshin, B.; Shetab-Boushehri, S.F.; Shetab-Boushehri, S.V. Feasibility of clinoptilolite application as a microporous carrier for pH-controlled oral delivery of metronidazole. Spec. Top. Rev. Porous Media Int. J., 2014, 5(4), 361-367.
[8]
Aghaii-Afshar, M.A.; Shetab-Boushehri, S.V. Extraction of parquat from blood by clinoptilolite. Adv. in Toxicol., 2014, 2014, 1-6.
[http://dx.doi.org/10.1155/2014/768706]
[9]
Limpitlaw, U.G. Ingestion of earth materials for health by humans and animals. Int. Geol. Rev., 2010, 52(7), 726-744.
[http://dx.doi.org/10.1080/00206811003679695]
[10]
Dobranowski, J.; Stringer, D.A.; Somers, S.; Stevenson, C.W. Procedures in Gastrointestinal Radiology, 1st ed; Springer-Verlag: New York, 1990.
[http://dx.doi.org/10.1007/978-1-4612-3308-4]
[11]
Mehta, H.S.; Bhatt, N.A.; Sen, D.J. Enteroclysis and computed tomographic enterography in medical imaging. Eur. J. Pharm. Med. Res., 2015, 2(3), 691-705.
[12]
Szurszewski, J.H. A 100-year perspective on gastrointestinal motility. Am. J. Physiol., 1998, 274(3), G447-G453.
[PMID: 9565541]
[13]
Ginai-Karamat, A.Z. Contrast Media for Radiological Examination in Gastrointestinal Tract Leakage: An Experimental and Clinical Study., PhD Thesis, Erasmus University Rotterdam: Rotterdam. 1987.
[14]
Neuman, E.W. Solubility relations of barium sulfate in aqueous solutions of strong electrolytes. J. Am. Chem. Soc., 1933, 55(3), 879-884.
[http://dx.doi.org/10.1021/ja01330a003]
[15]
Rosseinsky, D.R. The solubilities of sparingly soluble salts in water. Part 5. The solubility of barium sulphate at 25°C. Trans. Faraday Soc., 1958, 54, 116-118.
[http://dx.doi.org/10.1039/TF9585400116]
[16]
Burton, J.D.; Marshall, N.J.; Phillips, A.J. Solubility of barium sulphate in sea water. Nature, 1968, 217, 834-835.
[http://dx.doi.org/10.1038/217834a0]
[17]
Choudhury, H.; Colman, J.; Ingerman, L.; Robbins, P. Toxicological Review of Barium and Compounds, 1st ed; U.S. Environmental Protection Agency: Washington, DC, 2005.
[18]
Toxicological Profile for Barium and Barium Compounds, 1st ed; Agency for Toxic Substances and Disease Registry: Atlanta, USA, 2007.
[19]
Barium and Barium Compounds, 1st ed; World Health Organization: Geneva, Switzerland, 2001.
[20]
Randall, R.E., Jr; Osheroff, R.J.; Bakerman, S.; Setter, J.G. Bismuth nephrotoxicity. Ann. Intern. Med., 1972, 77(3), 481-482.
[http://dx.doi.org/10.7326/0003-4819-77-3-481] [PMID: 5053743]
[21]
Sarikaya, M.; Sevinc, A.; Ulu, R.; Ates, F.; Ari, F. Bismuth subcitrate nephrotoxicity. A reversible cause of acute oliguric renal failure. Nephron, 2002, 90(4), 501-502.
[http://dx.doi.org/10.1159/000054741] [PMID: 11961412]
[22]
Vinken, P.J.; Bruyn, G.E. Handbook of Clinical Neurology: Intoxications of the Nervous System, (part I, 1st ed. ) Elsevier: Amsterdam. 1994, 20(64), 331-351.
[23]
Jackson, B.P.; Miller, W.P. Arsenic and selenium speciation in coal fly ash extracts by ion chromatography-inductively coupled plasma mass spectrometry. J. Anal. At. Spectrom., 1998, 13(10), 1107-1112.
[http://dx.doi.org/10.1039/a806159i]
[24]
Feynman, R.P. There’s Plenty of Room at the Bottom: An Invitation to Enter a New Field of Physics. Eng. Sci., 1960, 23(5), 22-36.
[25]
Ames, L.L., Jr Cation sieve properties of clinoptilolite. Am. Mineral., 1960, 45(5-6), 689-700.
[26]
Ames, L.L., Jr Cation sieve properties of the open zeolites chabazite, mordenite, erionite and clinoptilolite. Am. Mineral., 1961, 46(9-10), 1120-1131.
[27]
Pabalan, R.T.; Bertetti, F.P. Cation-exchange properties of natural zeolites. Rev. Mineral. Geochem., 2001, 45(1), 453-518.
[http://dx.doi.org/10.2138/rmg.2001.45.14]
[28]
Sarkar, N.; Teot, A.S. Coagulation of negatively-charged colloids by anionic polyelectrolytes and metal ions. J. Colloid Interface Sci., 1973, 43(2), 370-381.
[http://dx.doi.org/10.1016/0021-9797(73)90383-4]
[29]
Swartzen-Allen, S.L.; Matijevic, E. Colloid and surface properties of clay suspensions. III. Stability of montmorillonite and kaolinite. J. Colloid Interface Sci., 1976, 56(1), 159-167.
[http://dx.doi.org/10.1016/0021-9797(76)90158-2]
[30]
Liu, Y.; Tourbin, M.; Lachaize, S.; Guiraud, P. Silica nanoparticle separation from water by aggregation with AlCl3. Ind. Eng. Chem. Res., 2012, 51(4), 1853-1863.
[http://dx.doi.org/10.1021/ie200672t]
[31]
Esmaiili, K.; Shetab-Boushehri, S.V. Comparative verification study of silica gel-coated TLC and HPTLC plates’ performances in separation of opium alkaloids on the basis of their physicochemical properties. J. Anal. Sci. Technol., 2017, 8, 1-7.
[http://dx.doi.org/10.1186/s40543-017-0131-z]
[32]
Ahadi, A.; Partoazar, A.; Abedi-Khorasgani, M.H.; Shetab-Boushehri, S.V. Comparison of liquid-liquid extraction-thin layer chromatography with solid-phase extraction-high-performance thin layer chromatography in detection of urinary morphine. J. Biomed. Res., 2011, 25(5), 362-367.
[http://dx.doi.org/10.1016/S1674-8301(11)60048-1] [PMID: 23554712]

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