N6-methyladenine RNA modification (m6A) is an RNA methylation modification catalyzed
by methyltransferase at the 6th position nitrogen atom of adenine (A), which is the most common
chemical modification of eukaryotic messenger RNA (mRNA). Recently, m6A has been found to play
an important role in the dynamic regulation of RNA, which is crucial for some physiological and
pathophysiological processes such as adipogenesis, cell differentiation, and the immune/inflammatory
response. Metabolic diseases are a series of chronic inflammatory disorders caused by metabolic dysfunction
of proteins, glucose, and lipids. Emerging studies have shown that m6A plays an important
role in the process of metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM) and cardiovascular
diseases (CVDs) via regulation of glucose/lipid metabolism and the immune/inflammatory
response. In this review, we will summarize the role of m6A in metabolic diseases, which may provide
new ideas for the prevention and treatment of metabolic diseases.
Keywords: N6-adenine methylation, metabolic diseases, obesity, type 2 diabetes mellitus, cardiovascular diseases.
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