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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

40% aq. HF Catalyzed Three-Component Synthesis of Novel Indeno[1, 2-b][1,8]naphthyridin-6(11H)-one Derivatives and their Antimicrobial Activity

Author(s): Srinu Bhoomandla, Phani Raja Kanuparthy*, Rambabu Gundla and Ramana Reddy Bobbala

Volume 18, Issue 1, 2021

Published on: 10 February, 2020

Page: [13 - 21] Pages: 9

DOI: 10.2174/1570178617666200210112843

Price: $65

Abstract

A three-component synthesis of novel 5-phenyl-2-(thiophen-2-yl)-4-(trifluoromethyl)-5Hindeno [1,2-b] [1,8] naphthyridin-6(11H)-one derivatives (4a-n) was prepared using 6-phenyl/ (thiophen- 2-yl)-4-(trifluoromethyl)pyridin-2-amine, 1H-indene-1,3(2H)-dione, and aryl aldehyde using 40% aq. HF with good yield. All the synthesized compounds were screened against Gram-positive and Gram-negative bacterial strains and different Candida strains by the well diffusion method. Compounds 4c, 4f, and 4g showed promising activity on Bacillus subtilis strain and compounds 4c and 4g showed promising activity towards Candida albicans strains.

Keywords: Naphthyridine, trifluoromethyl pyridine, 40% aq. HF, michael addition, antimicrobial activity, molecular docking studies.

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