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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Research Article

Neurocognitive and Psychiatric Markers for Addiction: Common vs. Specific Endophenotypes for Heroin and Amphetamine Dependence

Author(s): Elizabeth C. Long, Radka Kaneva, Georgi Vasilev, F. Gerard Moeller and Jasmin Vassileva*

Volume 20, Issue 7, 2020

Page: [585 - 597] Pages: 13

DOI: 10.2174/1568026620666200131124608

Price: $65

Abstract

Background: The differential utility of neurocognitive impulsivity and externalizing/ internalizing traits as putative endophenotypes for dependence on heroin vs. amphetamine is unclear.

Objective: This exploratory study aims to determine: (1) whether neurocognitive impulsivity dimensions and externalizing/internalizing traits are correlated between siblings discordant for heroin and amphetamine dependence; and (2) which of these associations are common across substances and which are substance- specific.

Methods: Pearson correlations between individuals with ‘pure’ heroin and amphetamine dependence and their unaffected biological siblings (n = 37 heroin sibling pairs; n = 30 amphetamine sibling pairs) were run on 10 neurocognitive measures, 6 externalizing measures, and 5 internalizing measures. Sibling pair effects were further examined using regression.

Results: Siblings discordant for heroin dependence were significantly correlated on delay aversion on the Cambridge Gambling Task, risk-taking on the Balloon Analogue Risk Task, sensation seeking, and hopelessness. Siblings discordant for amphetamine dependence were significantly correlated on the quality of decision-making on the Cambridge Gambling Task, discriminability on the Immediate Memory Task, commission errors on the Go/No Go Task, trait impulsivity, ADHD and anxiety sensitivity.

Conclusion: Dimensions of impulsivity and externalizing/internalizing traits appear to aggregate among siblings discordant for substance dependence. Risk-taking propensity, sensation seeking and hopelessness were specific for heroin sibling pairs. Motor/action impulsivity, trait impulsivity, and anxiety sensitivity were specific to amphetamine sibling pairs. Decisional/choice impulsivity was common across both heroin and amphetamine sibling pairs. These findings provide preliminary evidence for the utility of neurocognitive impulsivity and externalizing/ internalizing traits as candidate endophenotypes for substance dependence in general and for substance-specific dependencies.

Keywords: Addiction, Impulsivity, Externalizing, Internalizing, Endophenotypes, Discordant siblings.

« Previous
[1]
Merikangas, K.R.; McClair, V.L. Epidemiology of substance use disorders. Hum. Genet., 2012, 131(6), 779-789.
[http://dx.doi.org/10.1007/s00439-012-1168-0] [PMID: 22543841]
[2]
Goldman, D.; Oroszi, G.; Ducci, F. The genetics of addictions: uncovering the genes. Nat. Rev. Genet., 2005, 6(7), 521-532.
[http://dx.doi.org/10.1038/nrg1635] [PMID: 15995696]
[3]
Tsuang, M.T.; Lyons, M.J.; Meyer, J.M.; Doyle, T.; Eisen, S.A.; Goldberg, J.; True, W.; Lin, N.; Toomey, R.; Eaves, L. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch. Gen. Psychiatry, 1998, 55(11), 967-972.
[http://dx.doi.org/10.1001/archpsyc.55.11.967] [PMID: 9819064]
[4]
Agrawal, A.; Lynskey, M.T.; Madden, P.A.; Bucholz, K.K.; Heath, A.C. A latent class analysis of illicit drug abuse/dependence: results from the National Epidemiological Survey on Alcohol and Related Conditions. Addiction, 2007, 102(1), 94-104.
[http://dx.doi.org/10.1111/j.1360-0443.2006.01630.x] [PMID: 17207127]
[5]
Gottesman, I.I.; Gould, T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry, 2003, 160(4), 636-645.
[http://dx.doi.org/10.1176/appi.ajp.160.4.636] [PMID: 12668349]
[6]
Gilmore, C.S.; Malone, S.M.; Iacono, W.G. Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach. Behav. Genet., 2010, 40(2), 186-200.
[http://dx.doi.org/10.1007/s10519-010-9343-3] [PMID: 20155392]
[7]
Fineberg, N.A.; Potenza, M.N.; Chamberlain, S.R.; Berlin, H.A.; Menzies, L.; Bechara, A.; Sahakian, B.J.; Robbins, T.W.; Bullmore, E.T.; Hollander, E. Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review. Neuropsychopharmacology, 2010, 35(3), 591-604.
[http://dx.doi.org/10.1038/npp.2009.185] [PMID: 19940844]
[8]
Frederick, J.A.; Iacono, W.G. Beyond the DSM: defining endophenotypes for genetic studies of substance abuse. Curr. Psychiatry Rep., 2006, 8(2), 144-150.
[http://dx.doi.org/10.1007/s11920-006-0014-2] [PMID: 16539892]
[9]
Gau, S.S.F.; Shang, C.Y. Executive functions as endophenotypes in ADHD: evidence from the Cambridge Neuropsychological Test Battery (CANTAB). J. Child Psychol. Psychiatry, 2010, 51(7), 838-849.
[http://dx.doi.org/10.1111/j.1469-7610.2010.02215.x] [PMID: 20085608]
[10]
Rommelse, N.N.; Altink, M.E.; Oosterlaan, J.; Buschgens, C.J.; Buitelaar, J.; Sergeant, J.A. Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families. Psychol. Med., 2008, 38(11), 1595-1606.
[http://dx.doi.org/10.1017/S0033291708002869] [PMID: 18261248]
[11]
Glahn, D.C.; Almasy, L.; Barguil, M.; Hare, E.; Peralta, J.M.; Kent, J.W., Jr; Dassori, A.; Contreras, J.; Pacheco, A.; Lanzagorta, N.; Nicolini, H.; Raventós, H.; Escamilla, M.A. Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. Arch. Gen. Psychiatry, 2010, 67(2), 168-177.
[http://dx.doi.org/10.1001/archgenpsychiatry.2009.184] [PMID: 20124116]
[12]
Savitz, J.B.; Solms, M.; Ramesar, R.S. Neurocognitive function as an endophenotype for genetic studies of bipolar affective disorder. Neuromolecular Med., 2005, 7(4), 275-286.
[http://dx.doi.org/10.1385/NMM:7:4:275] [PMID: 16391385]
[13]
Kreek, M.J.; Nielsen, D.A.; Butelman, E.R.; LaForge, K.S. Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat. Neurosci., 2005, 8(11), 1450-1457.
[http://dx.doi.org/10.1038/nn1583] [PMID: 16251987]
[14]
MacKillop, J. Integrating behavioral economics and behavioral genetics: delayed reward discounting as an endophenotype for addictive disorders. J. Exp. Anal. Behav., 2013, 99(1), 14-31.
[http://dx.doi.org/10.1002/jeab.4] [PMID: 23344986]
[15]
Bickel, W.K. Discounting of delayed rewards as an endophenotype. Biol. Psychiatry, 2015, 77(10), 846-847.
[http://dx.doi.org/10.1016/j.biopsych.2015.03.003] [PMID: 25925716]
[16]
Winstanley, C.A.; Olausson, P.; Taylor, J.R.; Jentsch, J.D. Insight into the relationship between impulsivity and substance abuse from studies using animal models. Alcohol. Clin. Exp. Res., 2010, 34(8), 1306-1318.
[http://dx.doi.org/10.1111/j.1530-0277.2010.01215.x] [PMID: 20491734]
[17]
Hamilton, K.R. Choice impulsivity: Definitions, measurement issues, and clinical implications. Pers. Disord., 2015, 6(2), 182-198.
[http://dx.doi.org/10.1037/per0000099]
[18]
Hamilton, K.R.; Littlefield, A.K.; Anastasio, N.C.; Cunningham, K.A.; Fink, L.H.L.; Wing, V.C.; Mathias, C.W.; Lane, S.D.; Schütz, C.G.; Swann, A.C.; Lejuez, C.W.; Clark, L.; Moeller, F.G.; Potenza, M.N. Rapid-response impulsivity: definitions, measurement issues, and clinical implications. Pers. Disord., 2015, 6(2), 168-181.
[http://dx.doi.org/10.1037/per0000100] [PMID: 25867840]
[19]
Fineberg, N.A.; Chamberlain, S.R.; Goudriaan, A.E.; Stein, D.J.; Vanderschuren, L.J.; Gillan, C.M.; Shekar, S.; Gorwood, P.A.; Voon, V.; Morein-Zamir, S.; Denys, D.; Sahakian, B.J.; Moeller, F.G.; Robbins, T.W.; Potenza, M.N. New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity. CNS Spectr., 2014, 19(1), 69-89.
[http://dx.doi.org/10.1017/S1092852913000801] [PMID: 24512640]
[20]
George, O.; Koob, G.F. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci. Biobehav. Rev., 2010, 35(2), 232-247.
[http://dx.doi.org/10.1016/j.neubiorev.2010.05.002] [PMID: 20493211]
[21]
Verdejo-García, A.J.; Perales, J.C.; Pérez-García, M. Cognitive impulsivity in cocaine and heroin polysubstance abusers. Addict. Behav., 2007, 32(5), 950-966.
[http://dx.doi.org/10.1016/j.addbeh.2006.06.032] [PMID: 16876962]
[22]
Badiani, A.; Belin, D.; Epstein, D.; Calu, D.; Shaham, Y. Opiate versus psychostimulant addiction: the differences do matter. Nat. Rev. Neurosci., 2011, 12(11), 685-700.
[http://dx.doi.org/10.1038/nrn3104] [PMID: 21971065]
[23]
Rogers, R.D.; Everitt, B.J.; Baldacchino, A.; Blackshaw, A.J.; Swainson, R.; Wynne, K.; Baker, N.B.; Hunter, J.; Carthy, T.; Booker, E.; London, M.; Deakin, J.F.; Sahakian, B.J.; Robbins, T.W. Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology, 1999, 20(4), 322-339.
[http://dx.doi.org/10.1016/S0893-133X(98)00091-8] [PMID: 10088133]
[24]
Ersche, K.D.; Sahakian, B.J. The neuropsychology of amphetamine and opiate dependence: implications for treatment. Neuropsychol. Rev., 2007, 17(3), 317-336.
[http://dx.doi.org/10.1007/s11065-007-9033-y] [PMID: 17690986]
[25]
Fernández-Serrano, M.J.; Pérez-García, M.; Verdejo-García, A. What are the specific vs. generalized effects of drugs of abuse on neuropsychological performance? Neurosci. Biobehav. Rev., 2011, 35(3), 377-406.
[http://dx.doi.org/10.1016/j.neubiorev.2010.04.008] [PMID: 20451551]
[26]
Hussong, A.M.; Jones, D.J.; Stein, G.L.; Baucom, D.H.; Boeding, S. An internalizing pathway to alcohol use and disorder. Psychol. Addict. Behav., 2011, 25(3), 390-404.
[http://dx.doi.org/10.1037/a0024519] [PMID: 21823762]
[27]
King, S.M.; Iacono, W.G.; McGue, M. Childhood externalizing and internalizing psychopathology in the prediction of early substance use. Addiction, 2004, 99(12), 1548-1559.
[http://dx.doi.org/10.1111/j.1360-0443.2004.00893.x] [PMID: 15585046]
[28]
Krueger, R.F.; Hicks, B.M.; Patrick, C.J.; Carlson, S.R.; Iacono, W.G.; McGue, M. Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum. J. Abnorm. Psychol., 2002, 111(3), 411-424.
[http://dx.doi.org/10.1037/0021-843X.111.3.411] [PMID: 12150417]
[29]
Krueger, R.F.; Markon, K.E.; Patrick, C.J.; Benning, S.D.; Kramer, M.D. Linking antisocial behavior, substance use, and personality: an integrative quantitative model of the adult externalizing spectrum. J. Abnorm. Psychol., 2007, 116(4), 645-666.
[http://dx.doi.org/10.1037/0021-843X.116.4.645] [PMID: 18020714]
[30]
Bava, S.; Tapert, S.F. Adolescent brain development and the risk for alcohol and other drug problems. Neuropsychol. Rev., 2010, 20(4), 398-413.
[http://dx.doi.org/10.1007/s11065-010-9146-6] [PMID: 20953990]
[31]
Huijbregts, S.C.; Warren, A.J.; de Sonneville, L.M.; Swaab-Barneveld, H. Hot and cool forms of inhibitory control and externalizing behavior in children of mothers who smoked during pregnancy: an exploratory study. J. Abnorm. Child Psychol., 2008, 36(3), 323-333.
[http://dx.doi.org/10.1007/s10802-007-9180-x] [PMID: 17924184]
[32]
Stout, J.C.; Busemeyer, J.R.; Lin, A.; Grant, S.J.; Bonson, K.R. Cognitive modeling analysis of decision-making processes in cocaine abusers. Psychon. Bull. Rev., 2004, 11(4), 742-747.
[http://dx.doi.org/10.3758/BF03196629]
[33]
Stout, J.C.; Rock, S.L.; Campbell, M.C.; Busemeyer, J.R.; Finn, P.R. Psychological processes underlying risky decisions in drug abusers. Psychol. Addict. Behav., 2005, 19(2), 148-157.
[http://dx.doi.org/10.1037/0893-164X.19.2.148] [PMID: 16011385]
[34]
Ahn, W.Y.; Vasilev, G.; Lee, S.H.; Busemeyer, J.R.; Kruschke, J.K.; Bechara, A.; Vassileva, J. Decision-making in stimulant and opiate addicts in protracted abstinence: evidence from computational modeling with pure users. Front. Psychol., 2014, 5, 849.
[http://dx.doi.org/10.3389/fpsyg.2014.00849] [PMID: 25161631]
[35]
Passarotti, A.M.; Sweeney, J.A.; Pavuluri, M.N. Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder. Psychiatry Res., 2010, 181(1), 36-43.
[http://dx.doi.org/10.1016/j.pscychresns.2009.07.002] [PMID: 19926457]
[36]
Kirby, K.N.; Petry, N.M.; Bickel, W.K. Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. J. Exp. Psychol. Gen., 1999, 128(1), 78-87.
[http://dx.doi.org/10.1037/0096-3445.128.1.78]
[37]
Reynolds, B. A review of delay-discounting research with humans: relations to drug use and gambling. Behav. Pharmacol., 2006, 17(8), 651-667.
[http://dx.doi.org/10.1097/FBP.0b013e3280115f99] [PMID: 17110792]
[38]
Reynolds, B.; Fields, S. Delay discounting by adolescents experimenting with cigarette smoking. Addiction, 2012, 107(2), 417-424.
[http://dx.doi.org/10.1111/j.1360-0443.2011.03644.x] [PMID: 21906199]
[39]
Castellanos-Ryan, N.; Brière, F.N.; O’Leary-Barrett, M.; Banaschewski, T.; Bokde, A.; Bromberg, U.; Büchel, C.; Flor, H.; Frouin, V.; Gallinat, J.; Garavan, H.; Martinot, J.L.; Nees, F.; Paus, T.; Pausova, Z.; Rietschel, M.; Smolka, M.N.; Robbins, T.W.; Whelan, R.; Schumann, G.; Conrod, P. The structure of psychopathology in adolescence and its common personality and cognitive correlates. J. Abnorm. Psychol., 2016, 125(8), 1039-1052.
[http://dx.doi.org/10.1037/abn0000193] [PMID: 27819466]
[40]
Castellanos-Ryan, N.; Rubia, K.; Conrod, P.J. Response inhibition and reward response bias mediate the predictive relationships between impulsivity and sensation seeking and common and unique variance in conduct disorder and substance misuse. Alcohol. Clin. Exp. Res., 2011, 35(1), 140-155.
[http://dx.doi.org/10.1111/j.1530-0277.2010.01331.x] [PMID: 21039636]
[41]
Castellanos-Ryan, N.; Struve, M.; Whelan, R.; Banaschewski, T.; Barker, G.J.; Bokde, A.L.; Bromberg, U.; Büchel, C.; Flor, H.; Fauth-Bühler, M.; Frouin, V.; Gallinat, J.; Gowland, P.; Heinz, A.; Lawrence, C.; Martinot, J.L.; Nees, F.; Paus, T.; Pausova, Z.; Rietschel, M.; Robbins, T.W.; Smolka, M.N.; Schumann, G.; Garavan, H.; Conrod, P.J. Neural and cognitive correlates of the common and specific variance across externalizing problems in young adolescence. Am. J. Psychiatry, 2014, 171(12), 1310-1319.
[http://dx.doi.org/10.1176/appi.ajp.2014.13111499] [PMID: 25073448]
[42]
Nigg, J.T. On inhibition/disinhibition in developmental psychopathology: views from cognitive and personality psychology and a working inhibition taxonomy. Psychol. Bull., 2000, 126(2), 220-246.
[http://dx.doi.org/10.1037/0033-2909.126.2.220]
[43]
Roiser, J.P.; Sahakian, B.J. Hot and cold cognition in depression. CNS Spectr., 2013, 18(3), 139-149.
[http://dx.doi.org/10.1017/S1092852913000072] [PMID: 23481353]
[44]
Smoski, M.J.; Lynch, T.R.; Rosenthal, M.Z.; Cheavens, J.S.; Chapman, A.L.; Krishnan, R.R. Decision-making and risk aversion among depressive adults. J. Behav. Ther. Exp. Psychiatry, 2008, 39(4), 567-576.
[http://dx.doi.org/10.1016/j.jbtep.2008.01.004] [PMID: 18342834]
[45]
Lempert, K.M.; Pizzagalli, D.A. Delay discounting and future-directed thinking in anhedonic individuals. J. Behav. Ther. Exp. Psychiatry, 2010, 41(3), 258-264.
[http://dx.doi.org/10.1016/j.jbtep.2010.02.003] [PMID: 20219184]
[46]
Liu, R.T.; Vassileva, J.; Gonzalez, R.; Martin, E.M. A comparison of delay discounting among substance users with and without suicide attempt history. Psychol. Addict. Behav., 2012, 26(4), 980-985.
[http://dx.doi.org/10.1037/a0027384] [PMID: 22369220]
[47]
Erickson, K.; Drevets, W.C.; Clark, L.; Cannon, D.M.; Bain, E.E.; Zarate, C.A., Jr; Charney, D.S.; Sahakian, B.J. Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder. Am. J. Psychiatry, 2005, 162(11), 2171-2173.
[http://dx.doi.org/10.1176/appi.ajp.162.11.2171] [PMID: 16263859]
[48]
Williams, J.M.G.; Mathews, A.; MacLeod, C. The emotional Stroop task and psychopathology. Psychol. Bull., 1996, 120(1), 3-24.
[http://dx.doi.org/10.1037/0033-2909.120.1.3] [PMID: 8711015]
[49]
Mitterschiffthaler, M.T.; Williams, S.C.; Walsh, N.D.; Cleare, A.J.; Donaldson, C.; Scott, J.; Fu, C.H. Neural basis of the emotional Stroop interference effect in major depression. Psychol. Med., 2008, 38(2), 247-256.
[http://dx.doi.org/10.1017/S0033291707001523] [PMID: 17825123]
[50]
Etkin, A.; Egner, T.; Kalisch, R. Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn. Sci. (Regul. Ed.), 2011, 15(2), 85-93.
[http://dx.doi.org/10.1016/j.tics.2010.11.004] [PMID: 21167765]
[51]
Surguladze, S.; Brammer, M.J.; Keedwell, P.; Giampietro, V.; Young, A.W.; Travis, M.J.; Williams, S.C.; Phillips, M.L. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biol. Psychiatry, 2005, 57(3), 201-209.
[http://dx.doi.org/10.1016/j.biopsych.2004.10.028] [PMID: 15691520]
[52]
Song, S.; Zilverstand, A.; Song, H.; d’Oleire Uquillas, F.; Wang, Y.; Xie, C.; Cheng, L.; Zou, Z. The influence of emotional interference on cognitive control: A meta-analysis of neuroimaging studies using the emotional Stroop task. Sci. Rep., 2017, 7(1), 2088.
[http://dx.doi.org/10.1038/s41598-017-02266-2] [PMID: 28522823]
[53]
Ahn, W.Y.; Vassileva, J. Machine-learning identifies substance-specific behavioral markers for opiate and stimulant dependence. Drug Alcohol Depend., 2016, 161, 247-257.
[http://dx.doi.org/10.1016/j.drugalcdep.2016.02.008] [PMID: 26905209]
[54]
Wilson, M.J.; Vassileva, J. Decision-making under risk, but not under ambiguity, predicts pathological gambling in discrete types of abstinent substance users. Front. Psychiatry, 2018, 9, 239.
[55]
Vassileva, J.; Georgiev, S.; Martin, E.; Gonzalez, R.; Segala, L. Psychopathic heroin addicts are not uniformly impaired across neurocognitive domains of impulsivity. Drug Alcohol Depend., 2011, 114(2-3), 194-200.
[PMID: 21112701]
[56]
Vassileva, J.; Paxton, J.; Moeller, F.G.; Wilson, M.J.; Bozgunov, K.; Martin, E.M.; Gonzalez, R.; Vasilev, G. Heroin and amphetamine users display opposite relationships between trait and neurobehavioral dimensions of impulsivity. Addict. Behav., 2014, 39(3), 652-659.
[http://dx.doi.org/10.1016/j.addbeh.2013.11.020] [PMID: 24342174]
[57]
Vassileva, J.; Petkova, P.; Georgiev, S.; Martin, E.M.; Tersiyski, R.; Raycheva, M.; Velinov, V.; Marinov, P. Impaired decision-making in psychopathic heroin addicts. Drug Alcohol Depend., 2007, 86(2-3), 287-289.
[http://dx.doi.org/10.1016/j.drugalcdep.2006.06.015] [PMID: 16930861]
[58]
Segalà, L.; Vasilev, G.; Raynov, I.; Gonzalez, R.; Vassileva, J. Childhood Symptoms of ADHD and Impulsivity in Abstinent Heroin Users. J. Dual Diagn., 2015, 11(3-4), 174-178.
[http://dx.doi.org/10.1080/15504263.2015.1104482] [PMID: 26457770]
[59]
Wilson, M.J.; Vassileva, J. Neurocognitive and psychiatric dimensions of hot, but not cool, impulsivity predict HIV sexual risk behaviors among drug users in protracted abstinence. Am. J. Drug Alcohol Abuse, 2016, 42(2), 231-241.
[http://dx.doi.org/10.3109/00952990.2015.1121269] [PMID: 26837332]
[60]
First, M.B.; Gibbon, M. The structured clinical interview for DSM-iv axis i disorders (SCID-i) and the structured clinical interview for DSM-iv axis ii disorders (SCID-ii). In: Encyclopedia of Behavioral Medicine; Springer: New York, 2004.
[61]
Bechara, A.; Tranel, D.; Damasio, H. Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain, 2000, 123(Pt 11), 2189-2202.
[http://dx.doi.org/10.1093/brain/123.11.2189] [PMID: 11050020]
[62]
Robbins, T.W.; James, M.; Owen, A.M.; Sahakian, B.J.; McInnes, L.; Rabbitt, P. Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers. Dementia, 1994, 5(5), 266-281.
[PMID: 7951684]
[63]
Kvam, P. D.; Romeu, R. J.; Turner, B. M.; Vassileva, J.; Busemeyer, J. R. Testing the factor structure underlying behavior using joint cognitive models: Impulsivity in delay discounting and Cambridge gambling tasks. Psychol. Methods., 2020. [Epub ahead of print]
[http://dx.doi.org/10.31234/osf.io/4hw73]
[64]
Lejuez, C.W.; Read, J.P.; Kahler, C.W.; Richards, J.B.; Ramsey, S.E.; Stuart, G.L.; Strong, D.R.; Brown, R.A. Evaluation of a behavioral measure of risk taking: the Balloon Analogue Risk Task (BART). J. Exp. Psychol. Appl., 2002, 8(2), 75-84.
[http://dx.doi.org/10.1037/1076-898X.8.2.75] [PMID: 12075692]
[65]
Dougherty, D.M. Behavioral impulsivity paradigms: a comparison in hospitalized adolescents with disruptive behavior disorders. J. Child Psychol. Psychiatry, 2003, 44(8), 1145-1157.
[http://dx.doi.org/10.1111/1469-7610.00197]
[66]
Lane, S.D.; Moeller, F.G.; Steinberg, J.L.; Buzby, M.; Kosten, T.R. Performance of cocaine dependent individuals and controls on a response inhibition task with varying levels of difficulty. Am. J. Drug Alcohol Abuse, 2007, 33(5), 717-726.
[http://dx.doi.org/10.1080/00952990701522724] [PMID: 17891664]
[67]
Patton, J.H.; Stanford, M.S.; Barratt, E.S. Factor structure of the Barratt impulsiveness scale. J. Clin. Psychol., 1995, 51(6), 768-774.
[http://dx.doi.org/10.1002/1097-4679(199511)51:6<768:AID-JCLP2270510607>3.0.CO;2-1]
[68]
Zuckerman, M. The psychobiological model for impulsive unsocialized sensation seeking: a comparative approach. Neuropsychobiology, 1996, 34(3), 125-129.
[http://dx.doi.org/10.1159/000119303] [PMID: 8916069]
[69]
Buss, A.H.; Warren, W.L. Aggression questionnaire (AQ, Manual); Western Psychological Services: California, 2000.
[70]
Popov, V. Psychometric characterstics of the Bulgarian version of the Buss-Warren Aggression Questionnaire (BWAQ).(in Bulgarian). Clin. Consult. Psych., 2016, 4(30), 37-53.
[71]
Ward, M.F.; Wender, P.H.; Reimherr, F.W. The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am. J. Psychiatry, 1993, 150(6), 885-890.
[PMID: 8494063]
[72]
Nedelchev, D. Psychometric Characteristics of the Bulgarian version of the Wender Utah Rating Scale (WURS-25) for ADHD (in Bulgarian). Clin. Cons. Psych., 2016, 2(28), 3-17.
[73]
Hart, S.D.; Cox, D.N.; Hare, R.D. Psychopathy checklist: screening version (PCL:SV). In: Encyclopedia of personality and individual differences; Springer: Berlin, 1995.
[74]
Hare, R.D. The Hare psychopathy checklist-revised: Manual; Multi-Health Systems, Incorporated, 1991.
[75]
Wilson, M.J.; Abramowitz, C.; Vasilev, G.; Bozgunov, K.; Vassileva, J. Psychopathy in Bulgaria: The cross-cultural generalizability of the Hare Psychopathy Checklist. J. Psychopathol. Behav. Assess., 2014, 36(3), 389-400.
[http://dx.doi.org/10.1007/s10862-014-9405-6] [PMID: 25313268]
[76]
Beck, A.T.; Steer, R.A.; Brown, G.K. Beck depression inventory-II In: San Antonio; , 1996; 78, pp. (2)490-498.
[77]
Woicik, P.A.; Stewart, S.H.; Pihl, R.O.; Conrod, P.J. The Substance Use Risk Profile Scale: a scale measuring traits linked to reinforcement-specific substance use profiles. Addict. Behav., 2009, 34(12), 1042-1055.
[http://dx.doi.org/10.1016/j.addbeh.2009.07.001] [PMID: 19683400]
[78]
Long, E.C.; Milcheva, S.; Psederska, E.; Vasilev, G.; Bozgunov, K.; Nedelchev, D.; Gillespie, N.A.; Vassileva, J. Validation of the substance use risk profile scale (surps) with bulgarian substance dependent Individuals. Front. Psychol., 2018, 9, 2296.
[http://dx.doi.org/10.3389/fpsyg.2018.02296] [PMID: 30534101]
[79]
Reiss, S.; Peterson, R.A.; Gursky, D.M.; McNally, R.J. Anxiety sensitivity, anxiety frequency and the prediction of fearfulness. Behav. Res. Ther., 1986, 24(1), 1-8.
[http://dx.doi.org/10.1016/0005-7967(86)90143-9]
[80]
Olthuis, J.V.; Watt, M.C.; Stewart, S.H. Anxiety Sensitivity Index (ASI-3) subscales predict unique variance in anxiety and depressive symptoms. J. Anxiety Disord., 2014, 28(2), 115-124.
[http://dx.doi.org/10.1016/j.janxdis.2013.04.009] [PMID: 23770119]
[81]
Spielberger, C.D.; Gorsuch, R.L.; Lushene, R.; Vagg, P.R.; Jacobs, G.A. Manual for the State-Trait Anxiety Inventory; Consulting Psychologists Press: Palo Alto, 1983.
[82]
Shtetinski, D.; Paspalanov, I. STAI-Y: A questionnaire for the assessment of state and trait anxiety; OS Bulgaria: Sofia, 2008.
[83]
Bagby, R.M.; Parker, J.D.; Taylor, G.J. The twenty-item Toronto Alexithymia Scale--I. Item selection and cross-validation of the factor structure. J. Psychosom. Res., 1994, 38(1), 23-32.
[http://dx.doi.org/10.1016/0022-3999(94)90005-1]
[84]
Leising, D.; Grande, T.; Faber, R. The Toronto Alexithymia Scale (TAS-20): A measure of general psychological distress. J. Res. Pers., 2009, 43(4), 707-710.
[http://dx.doi.org/10.1016/j.jrp.2009.03.009]
[85]
Popov, V. Psychometric characteristics of the bulgarian version of the toronto alexithymia scale (tas-20) (in bulgarian). Psychol. Res., 2016, 19(2), 25-42.
[86]
R. Core Team. R: A language and environment for statistical computing, 2013. Available online at https://www.R-project.org/
[87]
Ersche, K.D.; Turton, A.J.; Pradhan, S.; Bullmore, E.T.; Robbins, T.W. Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits. Biol. Psychiatry, 2010, 68(8), 770-773.
[http://dx.doi.org/10.1016/j.biopsych.2010.06.015] [PMID: 20678754]
[88]
Ersche, K.D.; Turton, A.J.; Chamberlain, S.R.; Müller, U.; Bullmore, E.T.; Robbins, T.W. Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence. Am. J. Psychiatry, 2012, 169(9), 926-936.
[http://dx.doi.org/10.1176/appi.ajp.2012.11091421] [PMID: 22952072]
[89]
Shurman, J.; Koob, G.F.; Gutstein, H.B. Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Pain Med., 2010, 11(7), 1092-1098.
[http://dx.doi.org/10.1111/j.1526-4637.2010.00881.x] [PMID: 20545871]
[90]
Iacono, W.G.; Heath, A.C.; Hewitt, J.K.; Neale, M.C.; Banich, M.T.; Luciana, M.M.; Madden, P.A.; Barch, D.M.; Bjork, J.M. The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design. Dev. Cogn. Neurosci., 2018, 32, 30-42.
[http://dx.doi.org/10.1016/j.dcn.2017.09.001] [PMID: 29107609]
[91]
van der Sluis, S.; Verhage, M.; Posthuma, D.; Dolan, C.V. Phenotypic complexity, measurement bias, and poor phenotypic resolution contribute to the missing heritability problem in genetic association studies. PLoS One, 2010, 5(11)e13929
[http://dx.doi.org/10.1371/journal.pone.0013929] [PMID: 21085666]
[92]
Bilder, R.M.; Sabb, F.W.; Cannon, T.D.; London, E.D.; Jentsch, J.D.; Parker, D.S.; Poldrack, R.A.; Evans, C.; Freimer, N.B. Phenomics: the systematic study of phenotypes on a genome-wide scale. Neuroscience, 2009, 164(1), 30-42.
[http://dx.doi.org/10.1016/j.neuroscience.2009.01.027] [PMID: 19344640]
[93]
Sabb, F.W.; Burggren, A.C.; Higier, R.G.; Fox, J.; He, J.; Parker, D.S.; Poldrack, R.A.; Chu, W.; Cannon, T.D.; Freimer, N.B.; Bilder, R.M. Challenges in phenotype definition in the whole-genome era: multivariate models of memory and intelligence. Neuroscience, 2009, 164(1), 88-107.
[http://dx.doi.org/10.1016/j.neuroscience.2009.05.013] [PMID: 19450667]

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