Evaluation of Ficus retusa L. Leaves with Special Reference to Antidiarrheal and Anti-spasmodic Activity

Title:Evaluation of Ficus retusa L. Leaves with Special Reference to Antidiarrheal and Anti-spasmodic Activity

Volume: 18 Issue: 1

Author(s): Najam Ali Khan*, Chitra Tomar, Alankar Shrivastav, Aftab Ahmad and Arun Kumar Mishra

Affiliation:

• Pharmacology and Molecular Biology Research Laboratory, Faculty of Pharmacy, IFTM University, Moradabad 244102,India

Keywords: Diarrhea, Ficus retusa, magnesium sulphate, 5-HT induced, anti-spasmodic, natural drugs.

Abstract:

Aims: The aim of present investigation was to evaluate the traditional claim of Ficus retusa as an anti-diarrheal and anti-spasmodic agent using different pharmacological models.

Background: Diarrhea is considered as major cause of mortality, especially in children and aged persons. Because of diarrhoea, 17% of admitted children get die. In order to treat the diarrhea, natural drugs may be useful.

Objective: In order to prove the traditional claim of Ficus retusa, present work was undertaken with objective to prove antidiarrheal and antispasmodic activity.

Methods: The anti-diarrhoeal activity was evaluated by magnesium sulphate induced diarrhea and 5-hydroxy tryptamine(5HT) induced diarrhea. Further, the exact were subjected to gastrointestinal motility test using standard procedure.

Result: Finding of the present study suggested that significant response was exhibited by ethanolic extract (400mg/kg bw.) of Ficus retusa.

Conclusion: The response towards bioactivity was dose dependent. It was concluded that 400mg/kg bw of ethanolic extract is most potent in antidiarrhoeal and antispasmodic activity.

Cite this article as:

Khan Ali Najam *, Tomar Chitra , Shrivastav Alankar , Ahmad Aftab and Mishra Kumar Arun , Evaluation of Ficus retusa L. Leaves with Special Reference to Antidiarrheal and Anti-spasmodic Activity, Current Drug Discovery Technologies 2021; 18 (1) . https://dx.doi.org/10.2174/1570163817666200128100631