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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature

Author(s): Haijun Wang, Yin Shen, Lei Zhao* and Youfan Ye

Volume 28, Issue 3, 2021

Published on: 14 January, 2020

Page: [628 - 643] Pages: 16

DOI: 10.2174/0929867327666200114112728

Price: $65

Abstract

1-Deoxynojirimycin (1-DNJ) is a naturally occurring sugar analogue with unique bioactivities. It is found in mulberry leaves and silkworms, as well as in the metabolites of certain microorganisms, including Streptomyces and Bacillus. 1-DNJ is a potent α-glucosidase inhibitor and it possesses anti-hyperglycemic, anti-obese, anti-viral and anti-tumor properties. Some derivatives of 1-DNJ, like miglitol, miglustat and migalastat, were applied clinically to treat diseases such as diabetes and lysosomal storage disorders. The present review focused on the extraction, determination, pharmacokinetics and bioactivity of 1-DNJ, as well as the clinical application of 1-DNJ derivatives.

Keywords: 1-deoxynojirimycin, metabolites, miglitol, miglustat, imino sugars, glucosidase inhibitors.

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