Alzheimer Disease Diagnosis from fMRI Images Based on Latent Low Rank Features and Support Vector Machine (SVM)

(E-pub Ahead of Print)

Author(s): Nastaran Shahparian, Mehran Yazdi, Mohammad Reza Khosravi*

Journal Name: Current Signal Transduction Therapy

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Introduction: In recent years, resting-state functional magnetic resonance imaging (rsfMRI) has been increasingly used as a noninvasive and practical method in different areas of neuroscience and psychology for recognizing brain’s mechanism as well as diagnosing neurological diseases. In this work, we use rs-fMRI data for diagnosing Alzheimer's disease.

Materials and Methods: To do that, by using the rs-fMRI of a patient, we computed the time series of some anatomical regions and then applied the Latent Low Rank Representation method to extract suitable features. Next, based on the extracted features, we apply a Support Vector Machine (SVM) classifier to determine whether the patient belongs to a healthy category, mild stage of the disease or Alzheimer's stage.

Results: The obtained classification accuracy for the proposed method is more than 97.5%.

Conclusion: We performed different experiments on a database of rs-fMRI data containing the images of 43 healthy subjects, 36 mild cognitive impairment patients and 32 Alzheimer’s patients and the obtained results demonstrated that the best performance is achieved when the SVM with Gaussian kernel and the features of only 7 regions were used.

Keywords: Functional magnetic resonance imaging (fMRI); alzheimer disease; resting-state network; latent low rank representation; SVM.

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(E-pub Ahead of Print)
DOI: 10.2174/1574362414666191202144116

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