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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Regioselective Synthesis of Diverse Thio-, Seleno-substituted 1,2,3-Triazoles

Author(s): Lin-Lin Zhang, Qin-Pei Wu* and Zhi-Bin Xu

Volume 23, Issue 22, 2019

Page: [2379 - 2401] Pages: 23

DOI: 10.2174/1385272823666191108101604

Price: $65

Abstract

Thio-, seleno-substituted triazoles are useful scaffolds employed in the fields of organic synthesis, medicinal chemistry, and material science. A number of synthetic approaches to efficient formation of thio- and seleno-triazoles have been disclosed, including the interception of copper(I) triazolides generated in-situ, cycloaddition of internal alkynes (thio-, halo-, and metalated alkynes) to azides, and the coupling of azides and nonalkyne substrates. This mini-review intends to summarize the synthetic methods toward thio-, seleno-1,2,3-triazoles and the relative reaction mechanisms.

Keywords: Thioether, triazole, multi-component reaction, cycloaddition reaction, selenoether, regioselectivity.

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Graphical Abstract

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