The regulatory function of transcription factors on genes is not only related to the
location of binding genes and its related functions, but is also related to the methods of binding.
Different regulation effects result in different binding methods on target genes. Transcription
factors tend to combine with other transcription factors in the regulatory region to form a
competitive or synergistic relationship to regulate target genes accurately. We found that upregulated
genes in cancer cells were involved in the regulation of their own immune system related
to the normal cells. In this study, we provided a reliable theoretical basis for studying gene
expression regulation of co-binding transcription factors and further revealed the specific
regulation of transcription factor co-binding in cancer cells.
Keywords: Co-binding, transcription factor, target genes.
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