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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Gut Microbiome: Lactation, Childbirth, Lung Dysbiosis, Animal Modeling, Stem Cell Treatment, and CNS Disorders

Author(s): Sydney Corey, Lauren Kvederis, Chase Kingsbury, Brooke Bonsack, Paul R. Sanberg, Vanessa Castelli, Jea-Young Lee and Cesar V. Borlongan*

Volume 18, Issue 9, 2019

Page: [687 - 694] Pages: 8

DOI: 10.2174/1871527318666191021145252

Price: $65

Abstract

Here, we summarized recent advances in laboratory and clinical research on gut microbiome. The goal is to highlight recent discoveries on the biology and behavioral manifestations of gut microbiomes under normal and pathologic conditions. With this new scientific knowledge, we wish to cultivate cross-fertilization of science across multi-disciplines in the hopes of exploiting the gut microbiome as a key component of human development and its dysbiosis may signal pathological alterations that can be therapeutically targeted for regenerative medicine. In the end, we identify innovative research avenues that will merit from collaborations across biomedical disciplines that may facilitate the development of gut microbiome-based biomarkers and therapeutics. Gut microbiome stands as a core research area that transcends pediatric and nursing care, cancer biology, neurodegenerative disorders, cardiac function and diseases, among many other basic science and clinical arenas.

Keywords: Gut microbiota, inflammation, intestinal permeability, cell therapy, neurodegenerative diseases, breastfeeding, cancer biology, nursing.

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Graphical Abstract

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