Inhibitors of Cholinesterases in Pharmacology: the Current Trends

(E-pub Ahead of Print)

Author(s): Miroslav Pohanka*.

Journal Name: Mini-Reviews in Medicinal Chemistry

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Abstract:

Inhibitors of cholinesterases are a wide group of chemical compounds with a significant role in pharmacology. Beside the pharmacological purpose, they are also known as toxic compounds and military nerve agents. In the pharmacology, drugs for Alzheimer disease, myasthenia gravis and prophylaxis of poisoning by nerve agents can be mentioned as the relevant applications. Beside this, anti-inflammation and antiphrastic drugs are another pharmacological use of the inhibitors. This review is focused on survey of cholinesterase inhibitors with known or expected pharmacological impact and indications of their use. Recent literature with comments on it is provided here as well.

Keywords: acetylcholinesterase; Alzheimer disease; butyrylcholinesterase; myasthenia gravis; cholinergic anti-inflammatory pathway; nerve agents; galantamine; rivastigmine; donepezil; huperzine

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1389557519666191018170908
Price: $95

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