Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives

Renzo       Rossi; Maurizio       Ciofalo
Abstract

In recent years, the synthesis and evaluation of the biological properties of 1,2,4,5-tetrasubstituted-1H-imidazole derivatives have been the subject of a large number of studies by academia and industry. In these studies it has been shown that this large and highly differentiated class of heteroarene derivatives includes high valuable compounds having important biological and pharmacological properties such as antibacterial, antifungal, anthelmintic, anti-inflammatory, anticancer, antiviral, antihypertensive, cholesterol-lowering, antifibrotic, antiuricemic, antidiabetic, antileishmanial and antiulcer activities.
The present review with 411 references, in which we focused on the literature data published mainly from 2011 to 2017, aims to update the readers on the recent developments on the synthesis and biological evaluation of pharmacologically relevant 1,2,4,5-tetrasubstituted-1H-imidazole derivatives with an emphasis on their different molecular targets and their potential use as drugs to treat various types of diseases. Reference was also made to substantial literature data acquired before 2011 in this burgeoning research area.
Keywords: 1H-Imidazoles, drugs, inhibitors, antibacterial agents, antifungals, antivirals, anti-inflammatory agents, anticancer agents, antihypertensive agents, antiobesity agents, antileishmanial agents, synthesis, review.
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DOI https://dx.doi.org/10.2174/1385272823666191014154129	Print ISSN 1385-2728
Publisher Name Bentham Science Publisher	Online ISSN 1875-5348
Current Organic Chemistry

Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives

Abstract

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Advances of Heterocyclic Chemistry with Pesticide Activity

Calculation design of covalent/metal organic framework based catalysts

Carbohydrates conversion in biofuels and bioproducts

Catalytic C-H bond activation as a tool for functionalization of heterocycles

Current Organic Chemistry

Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Advances of Heterocyclic Chemistry with Pesticide Activity

Calculation design of covalent/metal organic framework based catalysts

Carbohydrates conversion in biofuels and bioproducts

Catalytic C-H bond activation as a tool for functionalization of heterocycles

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