Abstract
Type 1 diabetes mellitus (T1DM), an autoimmune disorder, is becoming widespread with approximately 97,700 children in India and 490,000 children worldwide affected. There are various etiological factors contributing to the expansion of its incidence on different geographical locations. Hence, the articles published in reputed journals were studies and data were collected for analyzing the etiology and prevention of T1DM. It has been observed that hybrid insulin peptides act as key antigens for the autoreactive T cells and cause the loss of self-tolerance in humans. The association of coxsackievirus B has been observed with the onset of T1DM. Accurate identification of the trigger can lead to the development of appropriate preventive measures. It can become a base for advance studies to prevent T1DM in humans. This review will highlight the causes and some preventive actions which can be considered to eliminate T1DM.
Keywords: Type 1 diabetes mellitus, etiology, pathogenesis, coxsackievirus B virus, prevention, NDM.
Current Diabetes Reviews
Title:Mapping of Type 1 Diabetes Mellitus
Volume: 16 Issue: 5
Author(s): Shivani Desai*Atul Deshmukh
Affiliation:
- Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri-Chinchwad,India
Keywords: Type 1 diabetes mellitus, etiology, pathogenesis, coxsackievirus B virus, prevention, NDM.
Abstract: Type 1 diabetes mellitus (T1DM), an autoimmune disorder, is becoming widespread with approximately 97,700 children in India and 490,000 children worldwide affected. There are various etiological factors contributing to the expansion of its incidence on different geographical locations. Hence, the articles published in reputed journals were studies and data were collected for analyzing the etiology and prevention of T1DM. It has been observed that hybrid insulin peptides act as key antigens for the autoreactive T cells and cause the loss of self-tolerance in humans. The association of coxsackievirus B has been observed with the onset of T1DM. Accurate identification of the trigger can lead to the development of appropriate preventive measures. It can become a base for advance studies to prevent T1DM in humans. This review will highlight the causes and some preventive actions which can be considered to eliminate T1DM.
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Cite this article as:
Desai Shivani *, Deshmukh Atul , Mapping of Type 1 Diabetes Mellitus, Current Diabetes Reviews 2020; 16 (5) . https://dx.doi.org/10.2174/1573399815666191004112647
DOI https://dx.doi.org/10.2174/1573399815666191004112647 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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