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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Review Article

Some Ways for the Synthesis of Chalcones - New Ways for the Synthesis of Flavon-3-ols

Author(s): Cecilia Espíndola *

Volume 17, Issue 6, 2020

Page: [647 - 673] Pages: 27

DOI: 10.2174/1570193X16666190919111252

Price: $65

Abstract

The flavonoids by their natural properties and their diverse applications are a group of compounds whose study of origin, characteristics and applications has been dedicated to extensive research. For the organic synthesis of chalcones, due to their interest as precursor molecules of different compounds, several pathways have been developed and reported in numerous works. Analyses on the effect of some of these catalysts on chalcone yield (%), with respect to time and reaction temperature are presented here. Given the importance of flavon-3-ols, as compounds of pharmacological interest mainly, new synthesis routes are proposed, in addition to the existing ones. This paper presents the main pathways for the synthesis of chalcones and analyzes their production. New routes for the synthesis of flavon-3-ols that follow the Claisen-Schmidt condensation and the interconversion of melacacidin are proposed.

Keywords: Flavonoids, (-)melacacidin, chalcones, Claisen-Schmidt condensation, flavon-3-ols, organic synthesis.

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