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Current Neurovascular Research

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ISSN (Print): 1567-2026
ISSN (Online): 1875-5739

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Research Article

Vitamin D as a Potential Agent for Ischemic Axonal Regeneration after Epineurial Devascularization of the Sciatic Nerve

Author(s): Huseyin Erdem, Levent Sarikcioglu, Neslihan Boyan and Ozkan Oguz*

Volume 16, Issue 4, 2019

Page: [392 - 401] Pages: 10

DOI: 10.2174/1567202616666190905160229

Price: $65

Abstract

Background: Although vitamin D has several noncalcemic functions particularly on nervous system, its neuroregenerative roles on ischemic peripheral nerve injury has not been reported. In this study, it was aimed to investigate the effect of vitamin D3 after epineurial devascularization of the sciatic nerve.

Methods: Forty adult female Wistar rats were randomly divided into four groups: Group 1 (Control), Group 2 (Sham-operated), Group 3 (Epineurial devascularization + vitamin D3 treatment), Group 4 (Epineurial devascularization + vehicle treatment). Recovery of the sciatic nerve was analyzed by functional (sciatic functional index, pinch test and biochemical analyses) and morphological (electron microscopic analysis and wet muscle weight analysis) methods.

Results: Comparison of the data revealed that vitamin D3 administration had a beneficial effect on regeneration after epineurial devascularization.

Conclusion: We suggest that vitamin D3 is an effective agent in the prevention of ischemic peripheral nerve insults.

Keywords: Epineurial vessels, neuroprotection, remyelination, sciatic nerve injury, vasa nervorum, vitamin D3.

« Previous
[1]
Evans GR. Peripheral nerve injury: A review and approach to tissue engineered constructs. Anat Rec 2001; 263(4): 396-404.
[http://dx.doi.org/10.1002/ar.1120] [PMID: 11500817]
[2]
Terzis JK, Sun DD, Thanos PK. Historical and basic science review: past, present, and future of nerve repair. J Reconstr Microsurg 1997; 13(3): 215-25.
[http://dx.doi.org/10.1055/s-2007-1006407] [PMID: 9101452]
[3]
Geuna S. The sciatic nerve injury model in pre-clinical research. J Neurosci Methods 2015; 243: 39-46.
[http://dx.doi.org/10.1016/j.jneumeth.2015.01.021] [PMID: 25629799]
[4]
Skouras E, Ozsoy U, Sarikcioglu L, Angelov DN. Intrinsic and therapeutic factors determining the recovery of motor function after peripheral nerve transection. Ann Anatomy 2011; 193(4): 286-303.
[http://dx.doi.org/10.1016/j.aanat.2011.02.014]
[5]
Scheib J, Höke A. Advances in peripheral nerve regeneration. Nat Rev Neurol 2013; 9(12): 668-76.
[http://dx.doi.org/10.1038/nrneurol.2013.227] [PMID: 24217518]
[6]
Roberts JT. The effect of occlusive arterial diseases of the extremities on the blood supply of nerves: Experimental and clinical studies on the role of the vasa nervorum. Am Heart J 1948; 35(3): 369-92.
[http://dx.doi.org/10.1016/0002-8703(48)90114-8] [PMID: 18903663]
[7]
Durward A. The blood supply of nerves. Postgrad Med J 1948; 24(267): 11-4.
[http://dx.doi.org/10.1136/pgmj.24.267.11] [PMID: 18901653]
[8]
Adams WE. The blood supply of nerves: I. Historical review. J Anat 1942; 76(Pt 4): 323-41.
[PMID: 17104901]
[9]
Sunderland S. Blood supply of the sciatic nerve and its popliteal divisions in man. Arch Neurol Psychiatry 1945; 54: 283-9.
[http://dx.doi.org/10.1001/archneurpsyc.1945.02300100057006] [PMID: 21006511]
[10]
Bell MA, Weddell AG. A morphometric study of intrafascicular vessels of mammalian sciatic nerve. Muscle Nerve 1984; 7(7): 524-34.
[http://dx.doi.org/10.1002/mus.880070703] [PMID: 6544371]
[11]
Sarikcioglu L, Demirel BM, Demir N, Yildirim FB, Demirtop A, Oguz N. Morphological and ultrastructural analysis of the watershed zones after stripping of the vasa nervorum. Int J Neurosci 2008; 118(8): 1145-55.
[http://dx.doi.org/10.1080/00207450801898220] [PMID: 18576212]
[12]
Hizay A, Demirel BM, Gokhan G, Sarikcioglu L, Demir N. Does FK506 reduce the size of the watershed area after vascular injury of the sciatic nerve? Romanian J Morphol Embryol 2011; 52(Suppl. 3): 1077-80.
[13]
Obrosova IG. Diabetes and the peripheral nerve. Biochim Biophys Acta 2009; 1792(10): 931-40.
[http://dx.doi.org/10.1016/j.bbadis.2008.11.005] [PMID: 19061951]
[14]
Li R, Liu Z, Pan Y, Chen L, Zhang Z, Lu L. Peripheral nerve injuries treatment: A systematic review. Cell Biochem Biophys 2014; 68(3): 449-54.
[http://dx.doi.org/10.1007/s12013-013-9742-1] [PMID: 24037713]
[15]
Martínez de Albornoz P, Delgado PJ, Forriol F, Maffulli N. Non-surgical therapies for peripheral nerve injury. Br Med Bull 2011; 100: 73-100.
[http://dx.doi.org/10.1093/bmb/ldr005] [PMID: 21429947]
[16]
Wolf G. The discovery of vitamin D: The contribution of Adolf Windaus. J Nutr 2004; 134(6): 1299-302.
[http://dx.doi.org/10.1093/jn/134.6.1299] [PMID: 15173387]
[17]
Urena-Torres P, Souberbielle JC. Pharmacologic role of vitamin D natural products. Curr Vasc Pharmacol 2014; 12(2): 278-85.
[http://dx.doi.org/10.2174/15701611113119990020] [PMID: 23713872]
[18]
Annweiler C, Annweiler T, Montero-Odasso M, Bartha R, Beauchet O. Vitamin D and brain volumetric changes: Systematic review and meta-analysis. Maturitas 2014; 78(1): 30-9.
[http://dx.doi.org/10.1016/j.maturitas.2014.02.013] [PMID: 24674855]
[19]
Beveridge LA, Witham MD. Vitamin D and the cardiovascular system. Osteopor Int 2013; 24(8): 2167-80.
[20]
Hewison M. Vitamin D and immune function: An overview. Proc Nutr Soc 2012; 71(1): 50-61.
[http://dx.doi.org/10.1017/S0029665111001650] [PMID: 21849106]
[21]
Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 2005; 29(1): 21-30.
[http://dx.doi.org/10.1016/j.jchemneu.2004.08.006] [PMID: 15589699]
[22]
Neveu I, Naveilhan P, Menaa C, Wion D, Brachet P, Garabédian M. Synthesis of 1,25-dihydroxyvitamin D3 by rat brain macrophages in vitro. J Neurosci Res 1994; 38(2): 214-20.
[http://dx.doi.org/10.1002/jnr.490380212] [PMID: 8078106]
[23]
Musiol IM, Stumpf WE, Bidmon HJ, Heiss C, Mayerhofer A, Bartke A. Vitamin D nuclear binding to neurons of the septal, substriatal and amygdaloid area in the Siberian hamster (Phodopus sungorus) brain. Neuroscience 1992; 48(4): 841-8.
[http://dx.doi.org/10.1016/0306-4522(92)90272-4] [PMID: 1321365]
[24]
Eyles D, Brown J, Mackay-Sim A, McGrath J, Feron F. Vitamin D3 and brain development. Neuroscience 2003; 118(3): 641-53.
[http://dx.doi.org/10.1016/S0306-4522(03)00040-X] [PMID: 12710973]
[25]
Kiraly SJ, Kiraly MA, Hawe RD, Makhani N. Vitamin D as a neuroactive substance. review Sci World J 2006; 6: 125-39.
[http://dx.doi.org/10.1100/tsw.2006.25] [PMID: 16493517]
[26]
Bianco J, Gueye Y, Marqueste T, et al. Vitamin D improves respiratory adjustment to fatigue and H-reflex responses in paraplegic adult rats. Neuroscience 2011; 188: 182-92.
[http://dx.doi.org/10.1016/j.neuroscience.2011.04.066] [PMID: 21571043]
[27]
Cornet A, Baudet C, Neveu I, Baron-Van Evercooren A, Brachet P, Naveilhan P. 1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. J Neurosci Res 1998; 53(6): 742-6.
[http://dx.doi.org/10.1002/(SICI)1097-4547(19980915)53:6<742:AID-JNR11>3.0.CO;2-#] [PMID: 9753201]
[28]
Chabas JF, Stephan D, Marqueste T, et al. Cholecalciferol (vitamin D3) improves myelination and recovery after nerve injury. PLoS One 2013; 8(5)e65034
[http://dx.doi.org/10.1371/journal.pone.0065034] [PMID: 23741446]
[29]
Montava M, Garcia S, Mancini J, et al. Vitamin D3 potentiates myelination and recovery after facial nerve injury. Eur Arch Otorhinolaryngol 2015; 272(10): 2815-3.
[http://dx.doi.org/10.1007/s00405-014-3305-y]
[30]
Bain JR, Mackinnon SE, Hunter DA. Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat. Plast Reconstr Surg 1989; 83(1): 129-38.
[http://dx.doi.org/10.1097/00006534-198901000-00024] [PMID: 2909054]
[31]
Schmelzer JD, Zochodne DW, Low PA. Ischemic and reperfusion injury of rat peripheral nerve. Proc Natl Acad Sci USA 1989; 86(5): 1639-42.
[http://dx.doi.org/10.1073/pnas.86.5.1639] [PMID: 2922402]
[32]
Myers RR. Anatomy and microanatomy of peripheral nerve. Neurosurg Clin N Am 1991; 2(1): 1-20.
[http://dx.doi.org/10.1016/S1042-3680(18)30753-8] [PMID: 1668260]
[33]
Myers RR, Heckman HM, Galbraith JA, Powell HC. Subperineurial demyelination associated with reduced nerve blood flow and oxygen tension after epineurial vascular stripping. Lab Invest 1991; 65(1): 41-50.
[PMID: 2072664]
[34]
Castaigne P, Brunet P, Hauw JJ, Léger JM, Gherardi R, Guillevin L. Peripheral nervous system and panarteritis nodosa. Review of 27 cases. Rev Neurol (Paris) 1984; 140(5): 343-52.
[PMID: 6147007]
[35]
Lundborg G. Structure and function of the intraneural microvessels as related to trauma, edema formation, and nerve function. J Bone Joint Surg Am 1975; 57(7): 938-48.
[http://dx.doi.org/10.2106/00004623-197557070-00011] [PMID: 171272]
[36]
Younger DS. Vasculitis of the nervous system. Curr Opin Neurol 2004; 17(3): 317-36.
[http://dx.doi.org/10.1097/00019052-200406000-00014] [PMID: 15167068]
[37]
Collins MP, Hadden RD. The nonsystemic vasculitic neuropathies. Nat Rev Neurol 2017; 13(5): 302-16.
[http://dx.doi.org/10.1038/nrneurol.2017.42] [PMID: 28447661]
[38]
Hawke SH, Davies L, Pamphlett R, Guo YP, Pollard JD, McLeod JG. Vasculitic neuropathy. A clinical and pathological study. Brain 1991; 114(Pt 5): 2175-90.
[http://dx.doi.org/10.1093/brain/114.5.2175] [PMID: 1657271]
[39]
Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 2005; 26(5): 662-87.
[http://dx.doi.org/10.1210/er.2004-0002] [PMID: 15798098]
[40]
Lemire JM, Archer DC. 1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis. J Clin Invest 1991; 87(3): 1103-7.
[http://dx.doi.org/10.1172/JCI115072] [PMID: 1705564]
[41]
Roder JD, Stair EL. An overview of cholecalciferol toxicosis. Veterin Human Toxicol 1999; 41(5): 344-43.
[42]
Wang TT, Tavera-Mendoza LE, Laperriere D, et al. Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol 2005; 19(11): 2685-95.
[http://dx.doi.org/10.1210/me.2005-0106] [PMID: 16002434]
[43]
Kimball S, Vieth R. Self-prescribed high-dose vitamin D3: Effects on biochemical parameters in two men. Ann Clin Biochem 2008; 45(Pt 1): 106-10.
[http://dx.doi.org/10.1258/acb.2007.007074] [PMID: 18275686]
[44]
Burton JM. A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis (vol 74, pg 1852, 2010). Neurology 2010; 75(11): 1029-29.
[45]
Kato S. The function of vitamin D receptor in vitamin D action. J Biochem 2000; 127(5): 717-22.
[http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022662] [PMID: 10788778]
[46]
Haussler MR, Whitfield GK, Haussler CA, et al. The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed. J Bone Mineral Res 1998; 13(3): 325-49.
[http://dx.doi.org/10.1359/jbmr.1998.13.3.325]
[47]
Wion D, MacGrogan D, Neveu I, Jehan F, Houlgatte R, Brachet P. 1,25-Dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesis. J Neurosci Res 1991; 28(1): 110-4.
[http://dx.doi.org/10.1002/jnr.490280111] [PMID: 1904101]
[48]
Niu Y, Li J, Peng R, et al. Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle-aged patients. Diabetes Metab Res Rev 2019. e3162
[49]
Anju M, Chacko L, Chettupalli Y, et al. Effect of Low Level Laser Therapy on serum vitamin D and magnesium levels in patients with diabetic peripheral neuropathy - A pilot study. Diabetes Metab Syndr 2019; 13(2): 1087-91.

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