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Current Biochemical Engineering (Discontinued)

Editor-in-Chief

ISSN (Print): 2212-7119
ISSN (Online): 2212-7127

Review Article

Vitamin C Loaded Chemically Modified Nano Carrier for Human Health Care Application

Author(s): Monalisha Sengupta*, Md. Adil Shaharyar, Mahfoozur Rahman, Kumar Anand and Anindita Kundu

Volume 6, Issue 1, 2020

Page: [34 - 40] Pages: 7

DOI: 10.2174/2212711906666190903113903

Abstract

Background: “Health is wealth” and to maintain it 7 essential nutrients are required. Among these, Vitamin is one that has great importance in very low concentration. As per the solubility, it divides into water-soluble and water-insoluble vitamins. This study concentrates on Vitamin C, a water-soluble vitamin which is essential for human growth due to its activity in the synthesis of carnitine, collagen, and neurotransmitter. It possesses antioxidant, antiatherogenic, and immunomodulatory functions, which may lead to the activity of Vitamin C in many diseases. But humans and some other non-human primates are unable to produce Vitamin C from glucose due to the absence of enzyme gulonolactone oxidase. As a result, humans are dependent on various dietary sources of Vc especially citrus fruit. But these dietary supplies also fail to achieve the required level in the body due to its poor bioavailability and storage.

Methods: Vitamin C has already proven its activity in cancer therapy. It is also used as a prodrug of H2O2. But due to the poor bioavailability and storage of Vitamin C in the human body, mankind is unable to avail the benefits of Vitamin C. These problems lead to generating different and suitable nanoformulations to incorporate Vitamin C and its derivatives into it. Different research work shows several ways to develop nanoformulations. Amongst all liposomes, microsphere, nanocarriers are of great importance. For Vitamin C incorporation into the nanoformulation, nanocarriers become the most popular choice for researchers. There were several nanocarrier systems developed using Chitosan- Alginate, Silica-Coated-Au Nanoparticles, Chitosan, Mesoporous-silica NCs for suitable incorporation of Vitamin C into these. The performances were assured by performing different in vitro and in vivo tests which will be discussed here.

Result: As a result, Vitamin C is now in use for many purposes. It includes not only the above mentioned functions but also other functions too. Due to an antioxidant property, Vitamin C is able to quench reactive oxygen species (ROS) by inhibiting ROS-mediated Nitric Oxide (NO) inactivation. Vitamin C helps to elevate the level of absorption of iron within the cell from dietary iron sources. It also prevents the oxidation of drugs. To achieve all these functions, NCs or nanoformulation plays a great role.

Conclusion: It can be concluded that depending on the biocompatibility, loading capacity, protection of the loading molecule, efficiency of cellular uptake, controllable rate of release to achieve the desired effect, and many more factors, the choice of different Nanocarriers (NCs) will be done which ultimately help the human to use it for different purposes. This paper tries to gather some information in one place with respect to different experimental studies.

Keywords: Vitamin C (Vc), Nanocarriers (NCs), Nanoparticles (NPs), chitosan, anti-oxidant, controlled release.

Graphical Abstract
[1]
J. Du, J.J. Cullen, and G.R. Buettner, "Ascorbic acid: Chemistry, biology and the treatment of cancer", Biochim. Biophys. Acta, vol. 1826, no. 2, pp. 443-457, 2012.
[PMID: 22728050]
[2]
E. Cameron, and A. Campbell, "The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer", Chem. Biol. Interact., vol. 9, no. 4, pp. 285-315, 1974.
[http://dx.doi.org/10.1016/0009-2797(74)90019-2] [PMID: 4430016]
[3]
E. Cameron, and L. Pauling, "Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer", IEEE Proc. Natl. Acad. Sci. USA.vol. 73, Oct 1976no. 10, pp. 3685,
[http://dx.doi.org/10.1073/pnas.73.10.3685]
[4]
Q. Chen, M.G. Espey, M.C. Krishna, J.B. Mitchell, C.P. Corpe, G.R. Buettner, E. Shacter, and M. Levine, "Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a prodrug to deliver hydrogen peroxide to tissues", IEEE Proc. Natl. Acad Sci. USA.vol. 102, no. 38, pp. 13604,
[http://dx.doi.org/10.1073/pnas.0506390102]
[5]
Q. Chen, M.G. Espey, A.Y. Sun, C. Pooput, K.L. Kirk, M.C. Krishna, D.B. Khosh, J. Drisko, and M. Levine, "Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice", IEEE Proc. Natl. Acad. Sci. USA.vol. 105, no. 32, pp. 11105-11109, 2008,
[6]
S. Basili, G. Tanzilli, E. Mangieri, V. Raparelli, S. Di Santo, P. Pignatelli, and F. Violi, "Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: Relationship with oxidative stress markers", JACC Cardiovasc. Interv., vol. 3, no. 2, pp. 221-229, 2010.
[http://dx.doi.org/10.1016/j.jcin.2009.10.025] [PMID: 20170881]
[7]
S. Taddei, A. Virdis, L. Ghiadoni, A. Magagna, and A. Salvetti, "Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension", Circulation, vol. 97, no. 22, pp. 2222-2229, 1998.
[http://dx.doi.org/10.1161/01.CIR.97.22.2222] [PMID: 9631871]
[8]
M.P. Valero, A.E. Fletcher, B.L. De Stavola, J. Vioque, and V.C. Alepuz, "Vitamin C is associated with reduced risk of cataract in a Mediterranean population", J. Nutr., vol. 132, no. 6, pp. 1299-1306, 2002.
[http://dx.doi.org/10.1093/jn/132.6.1299] [PMID: 12042450]
[9]
L. Hallberg, "Bioavailability of dietary iron in man", Annu. Rev. Nutr., vol. 1, pp. 123-147, 1981.
[http://dx.doi.org/10.1146/annurev.nu.01.070181.001011] [PMID: 6764713]
[10]
M. Nishikimi, and K. Yagi, "Biochemistry and molecular biology of ascorbic acid biosynthesis", Subcell. Biochem., vol. 25, pp. 17-39, 1996.
[http://dx.doi.org/10.1007/978-1-4613-0325-1_2] [PMID: 8821967]
[11]
M. Nishikimi, R. Fukuyama, S. Minoshima, N. Shimizu, and K. Yagi, "Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man", J. Biol. Chem., vol. 269, no. 18, pp. 13685-13688, 1994.
[PMID: 8175804]
[12]
K.A. Naidu, "Vitamin C in human health and disease is still a mystery? An overview", Nutr. J., vol. 2, p. 7, 2003.
[http://dx.doi.org/10.1186/1475-2891-2-7] [PMID: 14498993]
[13]
B. Frei, and M.G. Trabe, "The new US Dietary Reference Intakes for vitamins C and E", Redox Rep., vol. 6, no. 1, pp. 5-9, 2001.
[http://dx.doi.org/10.1179/135100001101535978] [PMID: 11333117]
[14]
Z.L. Liu, “Antioxidant activity of vitamin E and vitamin C derivatives in membrane mimetic systems,” in Bioradicals Detected by ESR Spectroscopy., Birkh¨auser: Basel, Switzerland, 1995.
[15]
J. Takebayashi, A. Tai, E. Gohda, and I. Yamamoto, "Characterization of the radical-scavenging reaction of 2-O-substituted ascorbic acid derivatives, AA-2G, AA-2P, and AA-2S: A kinetic and stoichiometric study", Biol. Pharm. Bull., vol. 29, no. 4, pp. 766-771, 2006.
[http://dx.doi.org/10.1248/bpb.29.766] [PMID: 16595915]
[16]
P. LoNostro, G. Capuzzi, P. Pinelli, N. Mulinacci, A. Romani, and F.F. Vincieri, "“Self-assembling and antioxidant activity of some vitamin C derivatives,” IEEE", Colloids Surf. A Physicochem. Eng. Asp., vol. 167, pp. 83-93, 2000.
[http://dx.doi.org/10.1016/S0927-7757(99)00465-3]
[17]
Y.S. Velioglu, G. Mazza, L. Gao, and B.D. Oomah, "Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products", IEEE J. Agricult. Food Chem., vol. 46, pp. 4113-4117, 1998.
[http://dx.doi.org/10.1021/jf9801973]
[18]
J.M. Gutteridge, "Biological origin of free radicals, and mechanisms of antioxidant protection", Chem. Biol. Interact., vol. 91, no. 2-3, pp. 133-140, 1994.
[http://dx.doi.org/10.1016/0009-2797(94)90033-7] [PMID: 8194129]
[19]
I. Al-Ogaidi, "“Evaluation of the Antioxidant and Anticancer Effects of Biodegradable/Biocompatible Chitosan–Alginate Nanoparticles Loaded with Vitamin C”, IEEE Int", J. Pharm. Res. Allied Sci., vol. 7, no. 3, pp. 189-197, 2018.
[20]
C.L. Linster, and E. Van Schaftingen, "Vitamin C. Biosynthesis, recycling and degradation in mammals", FEBS J., vol. 274, no. 1, pp. 1-22, 2007.
[http://dx.doi.org/10.1111/j.1742-4658.2006.05607.x] [PMID: 17222174]
[21]
S.J. Padayatty, and M. Levine, "Vitamin C: The known and the unknown and Goldilocks", Oral Dis., vol. 22, no. 6, pp. 463-493, 2016.
[http://dx.doi.org/10.1111/odi.12446] [PMID: 26808119]
[22]
I. Savini, A. Rossi, C. Pierro, L. Avigliano, and M.V. Catani, "SVCT1 and SVCT2: Key proteins for vitamin C uptake", Amino Acids, vol. 34, no. 3, pp. 347-355, 2008.
[http://dx.doi.org/10.1007/s00726-007-0555-7] [PMID: 17541511]
[23]
A. Javed, A. Sohail, R. Md, A. Saima, R. Mahfoozur, Z.A. Mohammad, A.R. Moshahid, A.K. Mohammad, and J.A. Farhan, "Nanotechnology-based inhalation treatments for lung cancer: state of the art", Nanotechnol. Sci. Appl., vol. 19, pp. 55-66, 2015.
[PMID: 26640374]
[24]
D.S. Stephanie, C-M. Mary, and A.P. Nicholas, "A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics", IEEE Eur. J. Pharm. Sci., vol. 48, pp. 416-427, 2013.
[http://dx.doi.org/10.1016/j.ejps.2012.12.006] [PMID: 23262059]
[25]
K.M. Hirenkumar, and J.S. Steven, "Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier", IEEE Polymers (Basel), vol. 3, pp. 1377-1397, 2011.
[http://dx.doi.org/10.3390/polym3031377] [PMID: 22577513]
[26]
M.J. Ramalho, and M. do Carmo Pereira, Nanoparticles for delivery of Vitamin D: Challenges and opportunities in", A Critical Evaluation of Vitamin D - Clinical Overview, April 2017,
[http://dx.doi.org/10.5772/64516]
[27]
P. Pandey, M. Rahman, P.C. Bhatt, S. Beg, B. Paul, A. Hafeez, F.A. Al-Abbasi, M.S. Nadeem, O. Baothman, F. Anwar, and V. Kumar, Im-plication of nano-antioxidant therapy for treatment of hepatocellular carcinoma using PLGA nanoparticles of rutin; Nanomedicine (Lond.).vol. 13, no. 8, pp. 849-870, 2018,
[http://dx.doi.org/10.2217/nnm-2017-0306] [PMID: 29565220]
[28]
V. Kumar, P.C. Bhatt, M. Rahman, G. Kaithwas, H. Choudhry, F.A. Al-Abbasi, F. Anwar, and A. Verma, "Fabrication, optimization, and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies", Int. J. Nanomedicine, vol. 12, pp. 6747-6758, 2017.
[http://dx.doi.org/10.2147/IJN.S136629] [PMID: 28932118]
[29]
M. Rahman, S. Beg, A. Verma, I. Kazmi, D.K. Patel, F. Anwar, F.A. Al Abbasi, and V. Kumar, "Therapeutic applications of liposomal based drug delivery and drug targeting for immune linked inflammatory maladies: A contemporary view point", Curr. Drug Targets, vol. 18, no. 13, pp. 1558-1571, 2017.
[http://dx.doi.org/10.2174/1389450118666170414113926] [PMID: 28413980]
[30]
M. Rahman, V. Kumar, S. Beg, G. Sharma, O.P. Katare, and F. Anwar, "Emergence of liposome as targeted magic bullet for inflammatory dis-orders: current state of the art", Artif. Cells Nanomed. Biotechnol., vol. 44, no. 7, pp. 1597-1608, 2016.
[http://dx.doi.org/10.3109/21691401.2015.1129617] [PMID: 26758815]
[31]
A. Sharma, and U.S. Sharma, "“Liposomes in drug delivery: Progress and limitations”, IEEE", Int. J. Pharm., vol. 154, pp. 123-140, 1997.
[http://dx.doi.org/10.1016/S0378-5173(97)00135-X]
[32]
A. Akbarzadeh, R. Rezaei-Sadabady, S. Davaran, S.W. Joo, N. Zarghami, Y. Hanifehpour, M. Samiei, M. Kouhi, and K. Nejati-Koshki, "Liposome: classification, preparation, and applications", Nanoscale Res. Lett., vol. 8, no. 1, p. 102, 2013.
[http://dx.doi.org/10.1186/1556-276X-8-102] [PMID: 23432972]
[33]
J. Siepmann, R.A. Siegel, and M.J. Rathbone, Fundamentals and applications of controlled release drug delivery. advances in delivery science and technology., Springer: US, 2012, pp. 289-328.
[34]
J. Ahmad, S. Amin, M. Rahman, R.A. Rub, M. Singhal, M.Z. Ahmad, Z. Rahman, R.T. Addo, F.J. Ahmad, G. Mushtaq, M.A. Kamal, and S. Akhter, "Solid matrix based lipidic nanoparticles in oral cancer chemotherapy: applications and pharmacokinetics", Curr. Drug Metab., vol. 16, no. 8, pp. 633-644, 2015.
[http://dx.doi.org/10.2174/1389200216666150812122128] [PMID: 26264206]
[35]
M.Z. Ahmad, S. Akhter, M. Anwar, A. Kumar, M. Rahman, A.H. Talasaz, and F.J. Ahmad, "Colorectal cancer targeted Irinotecan-Assam Bora rice starch based microspheres: a mechanistic, pharmacokinetic and biochemical investigation", Drug Dev. Ind. Pharm., vol. 39, no. 12, pp. 1936-1943, 2013.
[http://dx.doi.org/ 10.3109/03639045.2012.719906] [PMID: 23013140]
[36]
M.Z. Ahmad, S. Akhter, I. Ahmad, M. Rahman, M. Anwar, G.K. Jain, F.J. Ahmad, and R.K. Khar, "Development of polysaccharide based colon targeted drug delivery system: design and evaluation of Assam Bora rice starch based matrix tablet", Curr. Drug Deliv., vol. 8, no. 5, pp. 575-581, 2011.
[http://dx.doi.org/10.2174/156720111796642327] [PMID: 21696349]
[37]
M.Z. Ahmad, S. Akhter, I. Ahmad, M. Rahman, M. Anwar, G.K. Jain, F.J. Ahmad, and R.K. Khar, "Emergence of functionalized nanomedicines in can-cer chemotherapy: Recent advancements, current challenges and toxicity considerations", Recent Pat. Nanomed., vol. 3, pp. 128-139, 2013.
[38]
M. Rahman, M.Z. Ahmad, I. Kazmi, S. Akhter, Y. Kumar, F.J. Ahmad, and F. Anwar, "Novel approach for the treatment of cancer: Theranostic nanomedicine", Pharmacolgia, vol. 3, pp. 371-376, 2012.
[http://dx.doi.org/10.5567/pharmacologia.2012.371.376]
[39]
P. Aneja, M. Rahman, S. Beg, S. Aneja, V. Dhingra, and R. Chugh, "Cancer targeted magic bullets for effective treatment of cancer", Recent Pat Antiinfect Drug Discov, vol. 9, no. 2, pp. 121-135, 2014.
[http://dx.doi.org/10.2174/1574891X10666150415120506] [PMID: 25876849]
[40]
S. Akhter, Z. Ahmad, A. Singh, I. Ahmad, M. Rahman, M. Anwar, G.K. Jain, F.J. Ahmad, and R.K. Khar, "Cancer targeted metallic nanopar-ticle: Targeting overview, recent advancement and toxicity concern", Curr. Pharm. Des., vol. 17, no. 18, pp. 1834-1850, 2011.
[http://dx.doi.org/10.2174/138161211796391001] [PMID: 21568874]
[41]
M.Z. Ahmad, S. Akhter, G.K. Jain, M. Rahman, S.A. Pathan, F.J. Ahmad, and R.K. Khar, "Metallic nanoparticles: Technology overview & drug delivery applications in oncology", Expert Opin. Drug Deliv., vol. 7, no. 8, pp. 927-942, 2010.
[http://dx.doi.org/10.1517/17425247.2010.498473] [PMID: 20645671]
[42]
M. Rahman, M.Z. Ahmad, I. Kazmi, S. Akhter, M. Afzal, G. Gupta, and V.R. Sinha, "Emergence of nanomedicine as cancer targeted magic bullets: Recent development and need to address the toxicity apprehension", Curr. Drug Discov. Technol., vol. 9, no. 4, pp. 319-329, 2012.
[http://dx.doi.org/10.2174/157016312803305898] [PMID: 22725687]
[43]
M. Rahman, M.Z. Ahmad, I. Kazmi, S. Akhter, M. Afzal, G. Gupta, F. Jalees Ahmed, and F. Anwar, "Advancement in multifunctional nanoparticles for the effective treatment of cancer", Expert Opin. Drug Deliv., vol. 9, no. 4, pp. 367-381, 2012.
[44]
S. Beg, M. Rahman, A. Jain, S. Saini, P. Midoux, C. Pichon, F.J. Ahmad, and S. Akhter, "Nanoporous metal organic frameworks as hybrid polymer-metal composites for drug delivery and biomedical applications", Drug Discov. Today, vol. 22, no. 4, pp. 625-637, 2017.
[45]
A. Chakraborty, and N.R. Jana, "Vitamin C-conjugated nanoparticle protects cells from oxidative stress at low doses but induces oxidative stress and cell death at high doses", IEEE ACS Appl. Mater. Interfaces. vol. 9, no. pp. 41807-41817, 2017
[46]
O. Sarp, and K. Yurdakoç, "Controlled release of vitamin C from chitosan nanoparticles", IEEE Hacettepe J. Biol. & Chem, vol. 46, pp. 69-77, 2018.
[47]
L. Rashidi, E. Vasheghani-Farahani, K. Rostami, F. Gangi, and M. Fallahpour, "“Mesoporous silica nanoparticles as a nanocarrier for delivery of vitamin C”, IEEE Iran", J. Biotechnol., vol. 11, pp. 209-213, 2013.
[48]
S. Mitra, U. Gaur, P.C. Ghosh, and A.N. Maitra, "Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier", J. Control. Release, vol. 74, no. 1-3, pp. 317-323, 2001.
[49]
P. Pandey, M. Rahman, P.C. Bhatt, S. Beg, B. Paul, A. Hafeez, F.A. Al-Abbasi, M.S. Nadeem, O. Baothman, F. Anwar, and V. Kumar, "Implication of nano-antioxidant therapy for treatment of hepatocellular carcinoma using PLGA nanoparticles of rutin", Nanomedicine (Lond.), vol. 13, no. 8, pp. 849-870, 2018.
[50]
E. Jimnéz-Fernández, E. Zuasti, A. Ruyra, N. Roher, C. Infante, and C. Fernández-Díaz, "Nanoparticles as a novel delivery system for vita-min C administration in aquaculture", Commun. Agric. Appl. Biol. Sci., vol. 78, no. 4, pp. 202-203, 2013.
[51]
M. Zhou, X. Li, Y. Li, Q. Yao, Y. Ming, Z. Li, L. Lu, and S. Shi, "Ascorbyl palmitate-incorporated paclitaxel-loaded composite nanoparticles for synergistic anti-tumoral therapy", Drug Deliv., vol. 24, no. 1, pp. 1230-1242, 2017.
[52]
K. Santhi, S. Muralidharan, and H. Yee, "Y.; Y Min, F.; Z Ting, C.; Devi, D. “In-vitro characterization of chitosan nanoparticles of fluconazole as a carrier for sustained ocular delivery", IEEE Nanosci. Nanotechnol., vol. 7, pp. 41-50, 2017.
[53]
J. Gu, K. Al-Bayati, and E.A. Ho, "Development of antibody-modified chitosan nanoparticles for the targeted delivery of siRNA across the blood-brain barrier as a strategy for inhibiting HIV replication in astrocytes", Drug Deliv. Transl. Res., vol. 7, no. 4, pp. 497-506, 2017.
[54]
Y. Pan, Y.J. Li, H.Y. Zhao, J.M. Zheng, H. Xu, G. Wei, J.S. Hao, and F.D. Cui, "Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo", Int. J. Pharm., vol. 249, no. 1-2, pp. 139-147, 2002.
[http://dx.doi.org/10.1016/S0378-5173(02)00486-6] [PMID: 12433442]
[55]
K.A. Janes, M.P. Fresneau, A. Marazuela, A. Fabra, and M.J. Alonso, "Chitosan nanoparticles as delivery systems for doxorubicin", J. Control. Release, vol. 73, no. 2-3, pp. 255-267, 2001.
[http://dx.doi.org/10.1016/S0168-3659(01)00294-2] [PMID: 11516503]

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