Background: Apoptosis proteins have a key role in the development and the
homeostasis of the organism, and are very important to understand the mechanism of cell
proliferation and death. The function of apoptosis protein is closely related to its subcellular
Objective: Therefore, prediction of apoptosis protein subcellular localization is a meaningful task.
Method: In this study, we predict the apoptosis protein subcellular location by using the PSSMbased
second-order moving average descriptor, nonnegative matrix factorization based on
Kullback-Leibler divergence and over-sampling algorithms. This model is named by SOMAPKLNMF-
OS and constructed on the ZD98, ZW225 and CL317 benchmark datasets. Then, the
support vector machine is adopted as the classifier, and the bias-free jackknife test method is used
to evaluate the accuracy.
Results: Our prediction system achieves the favorable and promising performance of the overall
accuracy on the three datasets and also outperforms the other listed models.
Conclusion: The results show that our model offers a high throughput tool for the identification of
apoptosis protein subcellular localization.