Abstract
Background: Psychiatric disorders are common, reaching a worldwide prevalence of 29.2%. They are associated with a high risk of premature death and with accelerated aging in clinical, molecular and neuroimaging studies. Recently, there is strong evidence suggesting a possible role of telomere length and chemokines in aging processes in psychiatric disorders.
Objective: We aimed to review the literature on telomere length and chemokines and its association with early aging in mental illnesses on a transdiagnostic approach. Results: The review highlights the association between psychiatric disorders and early aging. Several independent studies have reported shorter telomere length and dysregulations on levels of circulating chemokines in schizophrenia, bipolar disorder, major depressive disorder, and anxiety disorders, suggesting a complex interaction between these markers in a transdiagnostic level. However, studies have investigated the inflammatory markers and telomere shortening separately and associated with a particular diagnosis, rather than as a transdiagnostic biological feature. Conclusion: There is consistent evidence supporting the relationship between accelerated aging, telomere length, and chemokines in mental disorders, but they have been studied individually. Thus, more research is needed to improve the knowledge of accelerated senescence and its biomarkers in psychiatry, not only individually in each diagnosis, but also based on a transdiagnostic perspective. Moreover, further research should try to elucidate how the intricate association between the chemokines and telomeres together may contribute to the aging process in psychiatric disorders.Keywords: Telomere length, chemokines, schizophrenia, bipolar disorder, major depressive disorder, anxiety disorders, aging, psychiatry.
Graphical Abstract
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12 October, 2024
Stress, anxiety and mental Health Assessment Using Artificial Intelligence
COVID-19 has greatly impacted the mental lives of people of all ages across the world. People whether infected with COVID or not have exhibited stress and anxiety and this has impacted their day-to-day lives. Increased digitalization, job pressures, health issues, and other factors have led to stress and mental issues. ...read more
07 September, 2024
The Power of Integration:Interactive Design and Bioengineering Shaping the Future of Autism Intervention
Over the next few years, what developments can be expected in the intersection of interactive technology with bioengineering-based interventions for autism and neuroscientific research? The field of interactive design has seen remarkable advancements, establishing robust methods that aid in autism education and enhance quality of life. Simultaneously, various computer-assisted methods ...read more
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