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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Systematic Review Article

Antioxidant Supplementation and Adaptive Response to Training: A Systematic Review

Author(s): Rosario Pastor and Josep A. Tur*

Volume 25, Issue 16, 2019

Page: [1889 - 1912] Pages: 24

DOI: 10.2174/1381612825666190701164923

Price: $65

Abstract

Background: Antioxidant supplementation has become a common practice among athletes to theoretically achieve a reduction in oxidative stress, promote recovery and improve performance.

Objective: To assess the effect of antioxidant supplements on exercise.

Methods: A systematic literature search was performed up to January 2019 in MEDLINE via EBSCO and Pubmed, and in Web of Sciences based on the following terms: “antioxidants” [Major] AND “exercise” AND “adaptation”; “antioxidant supplement” AND “(exercise or physical activity)” AND “(adaptation or adjustment)” [MesH]. Thirty-six articles were finally included.

Results: Exhaustive exercise induces an antioxidant response in neutrophils through an increase in antioxidant enzymes, and antioxidant low-level supplementation does not block this adaptive cellular response. Supplementation with antioxidants appears to decrease oxidative damage blocking cell-signaling pathways associated with muscle hypertrophy. However, upregulation of endogenous antioxidant enzymes after resistance training is blocked by exogenous antioxidant supplementation. Supplementation with antioxidants does not affect the performance improvement induced by resistance exercise. The effects of antioxidant supplementation on physical performance and redox status may vary depending on baseline levels.

Conclusion: The antioxidant response to exercise has two components: At the time of stress and adaptation through genetic modulation processes in front of persistent pro-oxidant situation. Acute administration of antioxidants immediately before or during an exercise session can have beneficial effects, such as a delay in the onset of fatigue and a reduction in the recovery period. Chronic administration of antioxidant supplements may impair exercise adaptations, and is only beneficial in subjects with low basal levels of antioxidants.

Keywords: Antioxidant, exercise, adaptation, systematic review, stress, genetic modulation.

« Previous
[1]
Peternelj TT, Coombes JS. Antioxidant supplementation during exercise training: Beneficial or detrimental? Sports Med 2011; 41(12): 1043-69.
[http://dx.doi.org/10.2165/11594400-000000000-00000] [PMID: 22060178]
[2]
Gómez-Cabrera MC, Domenech E, Romagnoli M, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 2008; 87(1): 142-9.
[http://dx.doi.org/10.1093/ajcn/87.1.142] [PMID: 18175748]
[3]
Ji LL. Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling. Free Radic Biol Med 2008; 44(2): 142-52.
[http://dx.doi.org/10.1016/j.freeradbiomed.2007.02.031] [PMID: 18191750]
[4]
Gros M, Baum O, Hoppeler H. Antioxidant supplementation and endurance training: Win or loss? Eur J Sport Sci 2011; 11: 27-32.
[http://dx.doi.org/10.1080/17461391003699088]
[5]
Padilla J, Mickleborough TD. Does antioxidant supplementation prevent favorable adaptations to exercise training? Med Sci Sports Exerc 2007; 39(10): 1887.
[http://dx.doi.org/10.1249/mss.0b013e31812383e8] [PMID: 17909422]
[6]
Funes L, Carrera-Quintanar L, Cerdán-Calero M, et al. Effect of lemon verbena supplementation on muscular damage markers, proinflammatory cytokines release and neutrophils’ oxidative stress in chronic exercise. Eur J Appl Physiol 2011; 111(4): 695-705.
[http://dx.doi.org/10.1007/s00421-010-1684-3] [PMID: 20967458]
[7]
Ackerman J, Clifford T, McNaughton L, Bentley D. The effect of an acute antioxidant supplementation compared with placebo on performance and hormonal response during a high-volume resistance training session. J int Soc Sport Nutr 2014; 11(1): 10.
[8]
Gómez-Cabrera MC, Martínez A, Santangelo G, Pallardó FV, Sastre J, Viña J. Oxidative stress in marathon runners: Interest of antioxidant supplementation. Br J Nutr 2006; 96(Suppl. 1): S31-3.
[http://dx.doi.org/10.1079/BJN20061696] [PMID: 16923247]
[9]
Tauler P, Aguiló A, Gimeno I, Fuentespina E, Tur JA, Pons A. Response of blood cell antioxidant enzyme defences to antioxidant diet supplementation and to intense exercise. Eur J Nutr 2006; 45(4): 187-95.
[http://dx.doi.org/10.1007/s00394-005-0582-7] [PMID: 16365696]
[10]
Morillas-Ruiz J, Zafrilla P, Almar M, et al. The effects of an antioxidant-supplemented beverage on exercise-induced oxidative stress: Results from a placebo-controlled double-blind study in cyclists. Eur J Appl Physiol 2005; 95(5-6): 543-9.
[http://dx.doi.org/10.1007/s00421-005-0017-4] [PMID: 16132121]
[11]
Khassaf M, McArdle A, Esanu C, et al. Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle. J Physiol 2003; 549(Pt 2): 645-52.
[http://dx.doi.org/10.1113/jphysiol.2003.040303] [PMID: 12692182]
[12]
Żychowska M, Jastrzębski Z, Chruściński G, Michałowska-Sawczyn M, Nowak-Zaleska A. Vitamin C A and E supplementation decreases the expression of HSPA1A and HSPB1 genes in the leukocytes of young polish figure skaters during a 10-day training camp. J Int Soc Sports Nutr 2015; 12: 9.
[http://dx.doi.org/10.1186/s12970-015-0069-8] [PMID: 25722659]
[13]
Morrison D, Hughes J, Della Gatta PA, et al. Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans. Free Radic Biol Med 2015; 89: 852-62.
[http://dx.doi.org/10.1016/j.freeradbiomed.2015.10.412] [PMID: 26482865]
[14]
Jówko E, Długołęcka B, Makaruk B, Cieśliński I. The effect of green tea extract supplementation on exercise-induced oxidative stress parameters in male sprinters. Eur J Nutr 2015; 54(5): 783-91.
[http://dx.doi.org/10.1007/s00394-014-0757-1] [PMID: 25120110]
[15]
Sureda A, Tauler P, Aguiló A, et al. Influence of an antioxidant vitamin-enriched drink on pre- and post-exercise lymphocyte antioxidant system. Ann Nutr Metab 2008; 52(3): 233-40.
[http://dx.doi.org/10.1159/000140515] [PMID: 18562790]
[16]
Carrera-Quintanar L, Funes L, Vicente-Salar N, et al. Effect of polyphenol supplements on redox status of blood cells: A randomized controlled exercise training trial. Eur J Nutr 2015; 54(7): 1081-93.
[http://dx.doi.org/10.1007/s00394-014-0785-x] [PMID: 25326831]
[17]
Morawin B, Turowski D, Naczk M, Siatkowski I, Zembron-Lacny A. The combination of α-lipoic acid intake with eccentric exercise modulates erythropoietin release. Biol Sport 2014; 31(3): 179-85.
[PMID: 25177095]
[18]
Howatson G, McHugh MP, Hill JA, et al. Influence of tart cherry juice on indices of recovery following marathon running. Scand J Med Sci Sports 2010; 20(6): 843-52.
[http://dx.doi.org/10.1111/j.1600-0838.2009.01005.x] [PMID: 19883392]
[19]
Kerksick CM, Kreider RB, Willoughby DS. Intramuscular adaptations to eccentric exercise and antioxidant supplementation. Amino Acids 2010; 39(1): 219-32.
[http://dx.doi.org/10.1007/s00726-009-0432-7] [PMID: 19967420]
[20]
Paulsen G, Cumming KT, Hamarsland H, Børsheim E, Berntsen S, Raastad T. Can supplementation with vitamin C and E alter physiological adaptations to strength training? BMC Sports Sci Med Rehabil 2014; 6: 28.
[http://dx.doi.org/10.1186/2052-1847-6-28] [PMID: 25075311]
[21]
Paulsen G, Cumming KT, Holden G, et al. Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: A double-blind, randomised, controlled trial. J Physiol 2014; 592(8): 1887-901.
[http://dx.doi.org/10.1113/jphysiol.2013.267419] [PMID: 24492839]
[22]
Schmidt MC, Askew EW, Roberts DE, Prior RL, Ensign WY Jr, Hesslink RE Jr. Oxidative stress in humans training in a cold, moderate altitude environment and their response to a phytochemical antioxidant supplement. Wilderness Environ Med 2002; 13(2): 49-105.
[http://dx.doi.org/10.1580/1080-6032(2002)013[0094:OSIHTI]2.0.CO;2] [PMID: 12092978]
[23]
Alway SE, McCrory JL, Kearcher K, et al. Resveratrol enhances exercise-induced cellular and functional adaptations of skeletal muscle in older men and women. J Gerontol A Biol Sci Med Sci 2017; 72(12): 1595-606.
[http://dx.doi.org/10.1093/gerona/glx089] [PMID: 28505227]
[24]
Paulsen G, Hamarsland H, Cumming KT, et al. Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training. J Physiol 2014; 592(24): 5391-408.
[http://dx.doi.org/10.1113/jphysiol.2014.279950] [PMID: 25384788]
[25]
Petersen AC, McKenna MJ, Medved I, et al. Infusion with the antioxidant N-acetylcysteine attenuates early adaptive responses to exercise in human skeletal muscle. Acta Physiol (Oxf) 2012; 204(3): 382-92.
[http://dx.doi.org/10.1111/j.1748-1716.2011.02344.x] [PMID: 21827635]
[26]
Palazzetti S, Rousseau AS, Richard MJ, Favier A, Margaritis I. Antioxidant supplementation preserves antioxidant response in physical training and low antioxidant intake. Br J Nutr 2004; 91(1): 91-100.
[http://dx.doi.org/10.1079/BJN20031027] [PMID: 14748941]
[27]
Michailidis Y, Karagounis LG, Terzis G, et al. Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise. Am J Clin Nutr 2013; 98(1): 233-45.
[http://dx.doi.org/10.3945/ajcn.112.049163] [PMID: 23719546]
[28]
Machado ÁS, da Silva W, Souza MA, Carpes FP. Green tea extract preserves neuromuscular activation and muscle damage markers in athletes under cumulative fatigue. Front Physiol 2018; 9: 1137.
[http://dx.doi.org/10.3389/fphys.2018.01137] [PMID: 30174618]
[29]
Dutra MT, Alex S, Mota MR, Sales NB, Brown LE, Bottaro M. Effect of strength training combined with antioxidant supplementation on muscular performance. Appl Physiol Nutr Metab 2018; 43(8): 775-81.
[http://dx.doi.org/10.1139/apnm-2017-0866] [PMID: 29939770]
[30]
McLeay Y, Stannard S, Barnes M. The Effect of Taurine on the Recovery from Eccentric Exercise-Induced Muscle Damage in Males. Antioxidants 2017; 6(4)E79
[http://dx.doi.org/10.3390/antiox6040079] [PMID: 29039798]
[31]
He F, Hockemeyer JA, Sedlock D. Does combined antioxidant vitamin supplementation blunt repeated bout effect? Int J Sports Med 2015; 36(5): 407-13.
[http://dx.doi.org/10.1055/s-0034-1395630] [PMID: 25607519]
[32]
Aguiló A, Tauler P, Sureda A, Cases N, Tur J, Pons A. Antioxidant diet supplementation enhances aerobic performance in amateur sportsmen. J Sports Sci 2007; 25(11): 1203-10.
[http://dx.doi.org/10.1080/02640410600951597] [PMID: 17654232]
[33]
Koivisto AE, Paulsen G, Paur I, et al. Antioxidant-rich foods and response to altitude training: A randomized controlled trial in elite endurance athletes. Scand J Med Sci Sports 2018; 28(9): 1982-95.
[http://dx.doi.org/10.1111/sms.13212] [PMID: 29749641]
[34]
Res PT, Cermak NM, Stinkens R, et al. Astaxanthin supplementation does not augment fat use or improve endurance performance. Med Sci Sports Exerc 2013; 45(6): 1158-65.
[http://dx.doi.org/10.1249/MSS.0b013e31827fddc4] [PMID: 23274592]
[35]
Shill DD, Southern WM, Willingham TB, Lansford KA, McCully KK, Jenkins NT. Mitochondria-specific antioxidant supplementation does not influence endurance exercise training-induced adaptations in circulating angiogenic cells, skeletal muscle oxidative capacity or maximal oxygen uptake. J Physiol 2016; 594(23): 7005-14.
[http://dx.doi.org/10.1113/JP272491] [PMID: 27501153]
[36]
Roberts LA, Beattie K, Close GL, Morton JP. Vitamin C consumption does not impair training-induced improvements in exercise performance. Int J Sports Physiol Perform 2011; 6(1): 58-69.
[http://dx.doi.org/10.1123/ijspp.6.1.58] [PMID: 21487150]
[37]
Furlong J, Rynders CA, Sutherlin M, et al. Effect of an herbal/botanical supplement on strength, balance, and muscle function following 12-weeks of resistance training: A placebo controlled study. J Int Soc Sports Nutr 2014; 11: 23.
[http://dx.doi.org/10.1186/1550-2783-11-23] [PMID: 24910543]
[38]
Paschalis V, Theodorou AA, Margaritelis NV, Kyparos A, Nikolaidis MG. N-acetylcysteine supplementation increases exercise performance and reduces oxidative stress only in individuals with low levels of glutathione. Free Radic Biol Med 2018; 115: 288-97.
[http://dx.doi.org/10.1016/j.freeradbiomed.2017.12.007] [PMID: 29233792]
[39]
Theodorou AA, Nikolaidis MG, Paschalis V, et al. No effect of antioxidant supplementation on muscle performance and blood redox status adaptations to eccentric training. Am J Clin Nutr 2011; 93(6): 1373-83.
[http://dx.doi.org/10.3945/ajcn.110.009266] [PMID: 21508092]
[40]
Buchman AL, Killip D, Ou CN, et al. Short-term vitamin E supplementation before marathon running: A placebo-controlled trial. Nutrition 1999; 15(4): 278-83.
[http://dx.doi.org/10.1016/S0899-9007(99)00005-2] [PMID: 10319359]
[41]
Sugita M, Kapoor MP, Nishimura A, Okubo T. Influence of green tea catechins on oxidative stress metabolites at rest and during exercise in healthy humans. Nutrition 2016; 32(3): 321-31.
[http://dx.doi.org/10.1016/j.nut.2015.09.005] [PMID: 26695876]

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