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Current Medicinal Chemistry

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General Review Article

Chemical and Bioactive Marine Natural Products of Coral-Derived Microorganisms (2015-2017)

Author(s): Xue-Mei Hou, Yang Hai, Yu-Cheng Gu, Chang-Yun Wang* and Chang-Lun Shao*

Volume 26, Issue 38, 2019

Page: [6930 - 6941] Pages: 12

DOI: 10.2174/0929867326666190626153819

Price: $65

Abstract

Coral-derived microorganisms are known for their inherent ability to produce novel products of pharmaceutical importance. Nearly 260 marine natural products (MNPs) have been isolated from coral-derived microorganisms till 2014. In the last three years, 118 MNPs have been isolated from coral-associated microorganisms including 46 new compounds, two with a novel skeleton, and four new natural products. Most of them exhibited in vitro or in vivo activities against tumor cell lines, parasites, pathogenic bacteria, fungi and virus. We reviewed the natural products reported from 2015 to 2017 that have a wide range of bioactivities against different biological targets.

Keywords: Coral-derived microorganism, marine natural product, bioactivity, drug potential, parasite, pathogenic bacteria.

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