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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Lipoproteins in Atherosclerosis Process

Author(s): Valentina Arnao, Antonino Tuttolomondo*, Mario Daidone and Antonio Pinto

Volume 26, Issue 9, 2019

Page: [1525 - 1543] Pages: 19

DOI: 10.2174/0929867326666190516103953

Price: $65

Abstract

Background: Dyslipidaemias is a recognized risk factor for atherosclerosis, however, new evidence brought to light by trials investigating therapies to enhance HDLcholesterol have suggested an increased atherosclerotic risk when HDL-C is high.

Results: Several studies highlight the central role in atherosclerotic disease of dysfunctional lipoproteins; oxidised LDL-cholesterol is an important feature, according to “oxidation hypothesis”, of atherosclerotic lesion, however, there is today a growing interest for dysfunctional HDL-cholesterol. The target of our paper is to review the functions of modified and dysfunctional lipoproteins in atherogenesis.

Conclusion: Taking into account the central role recognized to dysfunctional lipoproteins, measurements of functional features of lipoproteins, instead of conventional routine serum evaluation of lipoproteins, could offer a valid contribution in experimental studies as in clinical practice to stratify atherosclerotic risk.

Keywords: Lipoproteins, oxidised, dysfunctional, atherogenisis, dyslipidemia, HDL-C, atherosclerosis.

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