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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Research Article

Antihyperalgesic Activity of Quillaic Acid Obtained from Quillaja Saponaria Mol.

Author(s): Sylvia Arrau, Maité Rodríguez-Díaz*, Bruce K. Cassels, Gabriela Valenzuela-Barra, Carla Delporte*, Andrés Barriga and Hugo F. Miranda*

Volume 19, Issue 11, 2019

Page: [927 - 930] Pages: 4

DOI: 10.2174/1568026619666190509115741

Price: $65

Abstract

Background: Quillaja saponaria Mol. bark contains a high concentration of triterpene saponins that have been used for centuries as a cleansing, antiinflammatory and analgesic agent in Chilean folk medicine. In earlier studies, in mice, both the anti-inflammatory as well as the antinociceptive effect of the major sapogenin, quillaic acid have been demonstrated (QA).

Objective: To determine the antihyperalgesic effect of QA one and seven days after itpl administration of complete Freund's adjuvant (CFA) in male mice using the hot plate test in the presence of complete Freund's adjuvant (HP/CFA) as an acute and chronic skeletal muscle pain model.

Methods: The present study evaluated the antihyperalgesic activity of QA against acute and chronic skeletal muscle pain models in mice using the hot plate test in the presence of complete Freund's adjuvant (HP/CFA), at 24 h (acute assay) and 7 days (chronic assay) , with dexketoprofen (DEX) as the reference drug.

Results: In acute and chronic skeletal muscle pain assays, QA at 30 mg/kg ip elicited its maximal antihyperalgesic effects (65.0% and 53.4%) at 24 h and 7 days, respectively. The maximal effect of DEX (99.0 and 94.1 at 24 h and 7 days, respectively) was induced at 100 mg/kg.

Conclusion: QA and DEX elicit dose-dependent antihyperalgesic effects against acute and chronic skeletal muscle pain, but QA is more potent than DEX in the early and late periods of inflammatory pain induced by CFA.

Keywords: Quillaja saponaria, Quillaic acid, Skeletal muscle pain, Antihyperalgesic activity, Complete Freund's adjuvant, DEX.

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[1]
Kubitzki, K. The families and genera of vascular plants. Berlin & Heidelberg: Springer; , 2007, 9, pp. 407-408.
[2]
Guo, S.; Kenne, L. Characterization of some O-acetylated saponins from Quillaja saponaria Molina. Phytochemistry, 2000, 54(6), 615-623. [http://dx.doi.org/10.1016/S0031-9422(00)00161-8]. [PMID: 10963456].
[3]
Rodríguez-Díaz, M.; Delporte, C.; Cartagena, C.; Cassels, B.K.; González, P.; Silva, X.; León, F.; Wessjohann, L.A. Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives. J. Pharm. Pharmacol., 2011, 63(5), 718-724. [http://dx.doi.org/10.1111/j.2042-7158.2011.01263.x]. [PMID: 21492174].
[4]
Arrau, S.; Delporte, C.; Cartagena, C.; Rodríguez-Díaz, M.; González, P.; Silva, X.; Cassels, B.K.; Miranda, H.F. Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice. J. Ethnopharmacol., 2011, 133(1), 164-167. [http://dx.doi.org/10.1016/j.jep.2010.09.016]. [PMID: 20951193].
[5]
da Silva Arrigo, J.; Balen, E.; Júnior, U.L.; da Silva Mota, J.; Iwamoto, R.D.; Barison, A.; Sugizaki, M.M.; Leite Kassuya, C.A. Anti-nociceptive, anti-hyperalgesic and anti-arthritic activity of amides and extract obtained from Piper amalago in rodents. J. Ethnopharmacol., 2016, 179, 101-109. [http://dx.doi.org/10.1016/j.jep.2015.12.046]. [PMID: 26723468].
[6]
Zaringhalam, J.; Akbari, A.; Zali, A.; Manaheji, H.; Nazemian, V.; Shadnoush, M.; Ezzatpanah, S. Long-term treatment by vitamin B1 and reduction of serum proinflammatory cytokines, hyperalgesia, and paw edema in adjuvant-induced arthritis. Basic Clin. Neurosci., 2016, 7(4), 331-340. [http://dx.doi.org/10.15412/J.BCN.03070406]. [PMID: 27872694].
[7]
Lai, C.Y.; Lin, T.B.; Hsieh, M.C.; Chen, G.D.; Peng, H.Y. SIRPα1-SHP2 interaction regulates complete freund adjuvant-induced inflammatory pain via src-dependent glun2b phosphorylation in rats. Anesth. Analg., 2016, 122(3), 871-881. [http://dx.doi.org/10.1213/ANE.0000000000001116]. [PMID: 26720617].
[8]
Miranda, H.F.; Noriega, V.; Zanetta, P.; Prieto, J.C.; Prieto-Rayo, J.C.; Aranda, N.; Sierralta, F. Isobolographic analysis of the opioid-opioid interactions in a tonic and a phasic mouse model of induced nociceptive pain. J. Biomed. Sci., 2014, 21, 62-70. [http://dx.doi.org/10.1186/s12929-014-0062-6]. [PMID: 25017386].
[9]
Larson, A.A.; Brown, D.R.; el-Atrash, S.; Walser, M.M. Pain threshold changes in adjuvant-induced inflammation: A possible model of chronic pain in the mouse. Pharmacol. Biochem. Behav., 1986, 24(1), 49-53. [http://dx.doi.org/10.1016/0091-3057(86)90043-2]. [PMID: 3945666].
[10]
Tong, Z.; Cheng, L.; Song, J.; Wang, M.; Yuan, J.; Li, X.; Gao, H.; Wu, Z. Therapeutic effects of Caesalpinia minax Hance on complete Freund’s adjuvant (CFA)-induced arthritis and the anti-inflammatory activity of cassane diterpenes as main active components. J. Ethnopharmacol., 2018, 226, 90-96. [http://dx.doi.org/10.1016/j.jep.2018.08.011]. [PMID: 30114517].
[11]
Costigan, M.; Woolf, C. J. Pain: Molecular mechanisms. J. Pain, 2000, 1(3)(Suppl.), 35-44. [http://dx.doi.org/10.1054/jpai.2000.9818]. [PMID: 14622841].
[12]
Hartung, J.E.; Eskew, O.; Wong, T.; Tchivileva, I.E.; Oladosu, F.A.; O’Buckley, S.C.; Nackley, A.G. Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation. Brain Behav. Immun., 2015, 50, 196-202. [http://dx.doi.org/10.1016/j.bbi.2015.07.014]. [PMID: 26187567].
[13]
Miranda, H.F.; Puig, M.M.; Dursteler, C.; Prieto, J.C.; Pinardi, G. Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. Neuropharmacology, 2007, 52(2), 291-296. [http://dx.doi.org/10.1016/j.neuropharm.2006.07.025]. [PMID: 17074372].
[14]
Miranda, H.F.; Romero, M.A.; Puig, M.M. Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice. Fundam. Clin. Pharmacol., 2012, 26(3), 373-382. [http://dx.doi.org/10.1111/j.1472-8206.2010.00922.x]. [PMID: 22081874].
[15]
Bard, M.; Woods, R.A.; Bartón, D.H.; Corrie, J.E.; Widdowson, D.A. Sterol mutants of Saccharomyces cerevisiae: chromatographic analyses. Lipids, 1977, 12(8), 645-654. [http://dx.doi.org/10.1007/BF02533759]. [PMID: 331007].
[16]
Zhang, W.; Brombosz, S.M.; Mendoza, J.L.; Moore, J.S. A high-yield, one-step synthesis of o-phenylene ethynylene cyclic trimer via precipitation-driven alkyne metathesis. J. Org. Chem., 2005, 70(24), 10198-10201. [http://dx.doi.org/10.1021/jo0517803]. [PMID: 16292873].

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