Immunopathogenesis of Behçet Disease

Israel    Gañán    Nieto; José    Luis Castañer    Alabau
Abstract

Background: Behçet’s Disease (BD, OMIM 109650) is a chronic relapsing inflammatory disease of unknown etiology with unpredictable exacerbations and remissions. First described in 1937 by the Turkish dermatologist HulusiBehçet, as a trisympton complex (oral and genital ulcers and uveitis), it is now recognized as a multisystemic disease. The syndrome can manifest in diverse ways and can involve nearly every organ system. Several studies have implicated T cells and monocytes in the pathogenesis of BD especially when these cells are stimulated by heat shock proteins and streptococcal antigen. This article presents a review of the relevant published literature about the immunopathogenesis of BD.
Result: The authors used MeSH terms “Behçet’s disease” with “pathophysiology,” “pathogenesis,” “genetic”, “epigenetic”, “immunogenetic” or “immune response” to search the PubMed database. All the relevant studies identified were included.
Keywords: Behçet's disease, genetics, epigenetics, immunopathogenesis, etiology, pathophysiology.
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DOI https://dx.doi.org/10.2174/1573397115666190415142426	Print ISSN 1573-3971
Publisher Name Bentham Science Publisher	Online ISSN 1875-6360
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