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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

The Possibility of Preventive and Therapeutic Use of Green Tea Catechins in Prostate Cancer

Author(s): Vladimir S. Rogovskii*, Sergey V. Popov, Nikolai V. Sturov and Nikolai L. Shimanovskii

Volume 19, Issue 10, 2019

Page: [1223 - 1231] Pages: 9

DOI: 10.2174/1871520619666190404153058

Price: $65

Abstract

Background: Prostate cancer is one of the most frequent types of cancer. Despite the existence of various treatment strategies, treatment of prostate cancer still presents serious difficulties (especially in advanced stages). Polyphenols have been extensively assessed in terms of their potential use for prostate cancer treatment and prevention. Catechins are among the most well-known polyphenols in this respect.

Objective: In this review, we summarize clinical study results concerning catechin applications with regard to prostate cancer treatment and prevention. We discuss some of the main mechanisms of the anticarcinogenic action of catechins.

Conclusion: The main mechanisms of the anticarcinogenic action of catechins are subdivided into two major types: (i) direct action on cancer cells and (ii) indirect effect based on catechins’s impact on the microenvironment of cancer cells, particularly in relation to the immune system. At this level catechins might reduce tumor-associated inflammation and immune tolerance.

Keywords: Catechins, polyphenols, cancer, prostate cancer, inflammation, immunity, immune tolerance.

Graphical Abstract
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