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Current Nanoscience

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ISSN (Print): 1573-4137
ISSN (Online): 1875-6786

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Research Article

Aggregation-induced Emission-active Fluorescent Nanodot as a Potential Photosensitizer for Photodynamic Anticancer Therapy

Author(s): Ying Zhang, Huigang Chen, Qingxia Wang and Jing Sun*

Volume 16, Issue 1, 2020

Page: [112 - 120] Pages: 9

DOI: 10.2174/1573413715666190328182406

Price: $65

Abstract

Background: Photodynamic therapy (PDT) has become a very promising and effective strategy for the treatment of cancers and other malignant diseases. In recent years, photosensitizers (PS) with aggregation-induced emission (AIE) property have attracted great attention.

Objective: A high-performance AIE-active PS, E- 1-allyl-3-(2-(5-(4-(diphenylamino)phenyl) thiophene- 2-yl)vinyl)quinoxalin-2 (1H)-one (SJ-1), was synthesized and its PDT effect was preliminarily tested in vitro.

Methods: SJ-1 was designed using a quinoxalinone scaffold as the core chromophore. It could selfassembled into AIE-active nanoparticles with a mean size of 155 nm in aqueous medium and show maximum emission at 633 nm.

Results: SJ-1 nanoparticles at a concentration of 20 µM showed effective reactive oxygen species (ROS) production and could induce almost 90% decrease of cell viability under laser irradiation in Hela and HT-29 cells, with negligible dark toxicity.

Conclusion: In vitro results indicated that SJ-1 may be a potential PS for PDT.

Keywords: SJ-1, nanoparticles, photosensitizer, ROS, AIE, PDT.

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