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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

One-pot of Three-component Synthesis of Novel Biologically Important 5-Amino-1,3-diaryl-1H-pyrazole-4-carbonitriles Using L-Proline Catalyst and their Antimicrobial Activity

Author(s): Mohammad Reza Poor Heravi*, Mahdis Danafar and Niloofar Poor Heravi

Volume 16, Issue 11, 2019

Page: [922 - 930] Pages: 9

DOI: 10.2174/1570178616666190315155330

Price: $65

Abstract

An expeditious three-component synthesis of various biologically important heterocyclic compounds 5-amino-1,3-diaryl-1H-pyrazole-4-carbonitriles by condensation of aryl aldehydes, malononitrile and phenylhydrazine derivatives is described. This greener protocol was catalyzed by L-Proline and proceeded efficiently in solvent at room temperature within 2-15 min.

Keywords: Multicomponent reactions, 1H-pyrazole-4-carbonitriles, L-proline, antimicrobial activity, one-pot of threecomponent, organocatalyst.

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